Results 21 to 30 of about 150,542 (166)

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions [PDF]

, 2013
Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism.
O'Neill, Paul, Paine, Mark, Henderson, Colin, Hong, David W., Hong, David, Cravatt, Benjamin F., O'Neill, Paul M., Henderson, Colin J., Mahmoud, Hanafy, Finn, Robert D., Paine, Mark J. I., Finn, Robert, Ismail, Hanafy, Wright, Aaron T., Cravatt, Benjamin, Wright, Aaron, Paine, Mark; id_orcid, Hemingway, Janet, Ismail, Hanafy M.   +18 more
core   +1 more source

Licorice Ameliorates Cisplatin-Induced Hepatotoxicity Through Antiapoptosis, Antioxidative Stress, Anti-Inflammation, and Acceleration of Metabolism

Frontiers in Pharmacology, 2020
Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for
Qiong Man, Yi Deng, Yi Deng, Pengjie Li, Jun Ma, Zhijun Yang, Xiujuan Yang, Yan Zhou, Yan Zhou, Xiao Yan   +9 more
doaj   +1 more source

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. [PDF]

PLoS ONE, 2016
Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking.
Martin Krøyer Rasmussen, Patrick Balaguer, Bo Ekstrand, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin   +4 more
doaj   +1 more source

Danlu tongdu tablets: Preclinical safety evaluation and mechanism of hepatotoxicity

Frontiers in Pharmacology, 2022
Danlu tongdu tablets (DLTD) is a listed Chinese patent medicine collected in the Pharmacopoeia of the People’s Republic of China (version 2020). This prescription has been applied in clinics in China for lumbar spinal stenosis and lumbosacral disc ...
Haijing Zhang, Yifei Yang, Feifei Guo, Rong He, Shuangrong Gao, Chunyu Cao, Chunhui Zhao, Bing Xia, Qihua Xu, Ping Gong, Lifang Wang, Ping Su, Ting Liu   +12 more
doaj   +1 more source

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

Molecules, 2013
With the widespread use of O-alkoxyresorufin dealkylation assays since the 1990s, thousands of inhibitors of cytochrome P450 family 1 enzymes (P450s 1A1, 1A2, and 1B1) have been identified and studied.
Jiawang Liu, Jayalakshmi Sridhar, Maryam Foroozesh   +2 more
doaj   +1 more source

Ethynylflavones, highly potent, and selective inhibitors of cytochrome P450 1A1. [PDF]

Chem Res Toxicol, 2014
The flavone backbone is a well-known pharmacophore present in a number of substrates and inhibitors of various P450 enzymes. In order to find highly potent and novel P450 family I enzyme inhibitors, an acetylene group was incorporated into six different ...
Goyal N, Liu J, Lovings L, Dupart P, Taylor S, Bellow S, Mensah L, McClain E, Dotson B, Sridhar J, Zhang X, Zhao M, Foroozesh M.   +12 more
europepmc   +2 more sources

Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]

, 2008
Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun, Gudrun Hintereder, Michael P. Manns, Christen, Urs, Herrath, Matthias G. von, Holdener, Martin, Monika Bayer, Johnson, Eric F., Urs Christen, Rodrigo, Evelyn, Frank J. Gonzalez, Pfeilschifter, Josef (Prof. Dr.), Eric F. Johnson, Evelyn Rodrigo, Gonzalez, Frank J., Martin Holdener, Edith Hintermann, Hintermann, Edith, Matthias von G. Herrath, Josef Pfeilschifter, Rhode, Antje, Bayer, Monika, Manns, Michael P., Antje Rhode   +23 more
core   +1 more source

Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]

, 2013
Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo, Klausen, Christina Lindgaard, Rasmussen, Martin Krøyer   +2 more
core   +1 more source

In Vitro and In Vivo Effect of Xylopic Acid on Cytochrome P450 Enzymes

Advances in Pharmacological and Pharmaceutical Sciences, 2022
Introduction. Xylopic acid (XA), the major constituent of the fruit of Xylopia aethiopica, has shown several pharmacological properties. Traditionally, the plant is used to treat several diseases and is being used in the preparation of several local ...
Mary A. Agbenyeku, Regina Appiah-Opong, Ernest Obese, Robert P. Biney, Emmanuel A. Adakudugu, Arnold D. Forkuo, Silas A. Osei, Mustapha K. Abeka, Elvis O. Ameyaw   +8 more
doaj   +1 more source

Effect of Methomyl on the Phenobarbital and Benzo [a] Pyrene Induced Hepatic Microsomal Mixed Function Oxidase System in Rats [PDF]

Al Ameen Journal of Medical Sciences, 2011
Methomyl (Lannate) is a pesticide widely used to control of insects in grape gardens. Methomyl treatment induces significant alteration in mixed function oxidase system.
Jyotsna A. Patil1, Arun J. Patil1*, Ajit V. Sontakke1, Satish D. Kalme2 and Sanjay P. Govindwar3
doaj