Results 21 to 30 of about 174,785 (211)
Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme. [PDF]
Drug Metab Lett, 2017 Members of the cytochrome P450 1A family metabolize many procarcinogens such as polycyclicaromatic hydrocarbons and heterocyclic amines. Inactivation of these enzymes is a prerequisite for cancer prevention and treatment in certain cases. Mechanism-based inhibition (time and co-factor dependent) is an effective method for the inactivation of these ...
Sridhar J +7 more
europepmc +4 more sources
Italian Journal of Animal Science, 2022 The effects of lycopene on liver damage in Aflatoxin B1 (AFB1)-challenged broilers were investigated. A total of 240 Arbour Acres Broilers in five groups were fed basal diet (control), basal diet with 100 μg/kg AFB1 (AFB1), AFB1 diet with 100, 200, and ...
Xiaoli Wan +8 more
doaj +1 more source
Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions [PDF]
, 2013 Pyrethroid insecticides are used to control diseases spread by arthropods. We have developed a suite of pyrethroid mimetic activity-based probes (PyABPs) to selectively label and identify P450s associated with pyrethroid metabolism.
O'Neill, Paul +18 more
core +1 more source
Environment International, 2022 Nitropolycyclic aromatic hydrocarbons (NPAHs) present one of the most important airborne pollutants. Recent studies have shown that one of the most abundant NPAHs, 2-Nitrofluorene (NF), was supposed to be converted to endocrine-disrupting metabolites by ...
Junhua Zhou +5 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Cisplatin (CP) is one of the most effective antitumor drugs in the clinic, but has serious adverse reactions, and its hepatotoxicity has not been fully investigated. Licorice (GC), a traditional herbal medicine, has been commonly used as a detoxifier for
Qiong Man +9 more
doaj +1 more source
Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes. [PDF]
PLoS ONE, 2016 Skatole (3-methylindole) is a product of bacterial fermentation of tryptophan in the intestine. A significant amount of skatole can also be inhaled during cigarette smoking.
Martin Krøyer Rasmussen +4 more
doaj +1 more source
Danlu tongdu tablets: Preclinical safety evaluation and mechanism of hepatotoxicity
Frontiers in Pharmacology, 2022 Danlu tongdu tablets (DLTD) is a listed Chinese patent medicine collected in the Pharmacopoeia of the People’s Republic of China (version 2020). This prescription has been applied in clinics in China for lumbar spinal stenosis and lumbosacral disc ...
Haijing Zhang +12 more
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In Vitro and In Vivo Effect of Xylopic Acid on Cytochrome P450 Enzymes
Advances in Pharmacological and Pharmaceutical Sciences, 2022 Introduction. Xylopic acid (XA), the major constituent of the fruit of Xylopia aethiopica, has shown several pharmacological properties. Traditionally, the plant is used to treat several diseases and is being used in the preparation of several local ...
Mary A. Agbenyeku +8 more
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Effect of Methomyl on the Phenobarbital and Benzo [a] Pyrene Induced Hepatic Microsomal Mixed Function Oxidase System in Rats [PDF]
Al Ameen Journal of Medical Sciences, 2011 Methomyl (Lannate) is a pesticide widely used to control of insects in grape gardens. Methomyl treatment induces significant alteration in mixed function oxidase system.
Jyotsna A. Patil1, Arun J. Patil1*, Ajit V. Sontakke1, Satish D. Kalme2 and Sanjay P. Govindwar3
doaj
Evaluation of 2-Year-Old Intrasplenic Fetal Liver Tissue Transplants in Rats
Cell Transplantation, 2003 Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency.
Amelie Lupp DR. +2 more
doaj +1 more source