Results 31 to 40 of about 174,785 (211)
BMC Cancer, 2022 Background Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxification of anticancer drugs and carcinogens.
Samina Naz Mukry +3 more
doaj +1 more source
Asian Journal of Andrology, 2022 To explore the relationship between genetic polymorphisms of metabolic enzymes such as CYP1A1, CYP2D6, GSTM1, GSTT1, and GSTP1 and idiopathic male infertility. By observing the efficacy of antioxidants in the treatment of idiopathic male infertility, the
Hong-Yan Zhang +9 more
doaj +1 more source
Regulation of cytochrome P450 mRNA expression in primary porcine hepatocytes by selected secondary plant metabolites from chicory (Cichorium intybus L.) [PDF]
, 2013 Chicory (Cichorium intybus) has been shown to induce enzymes of pharmacokinetic relevance (cytochrome P450; CYP). The aim of this study was to investigate the effects of selected secondary plant metabolites with a global extract of chicory root, on the ...
Ekstrand, Bo +2 more
core +1 more source
Sensors, 2009 In the present study, we characterized the kinetic parameters of 7-ethoxy-resorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) in hepatic microsomes from entire and castrated male pigs.
Vladimir Zlabek, Galia Zamaratskaia
doaj +1 more source
Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection [PDF]
, 2008 Autoimmune liver diseases, such as autoimmune hepatitis (AIH) and primary biliary cirrhosis, often have severe consequences for the patient. Because of a lack of appropriate animal models, not much is known about their potential viral etiology. Infection
Hintereder, Gudrun +23 more
core +1 more source
, 1993 Cytochrome P450 1A1 was localized immunohistochemically and benzo[a]pyrene hydroxylase activity was identified in situ by means of fluorescence histochemistry in the nasal mucosa of untreated, 3-methylcholanthrene-treated or Aroclor 1254-treated rats ...
J Baron, F P Guengerich, J M Voigt
core +1 more source
Expression of recombinant human cytochrome P450 in Ames test strains for mutagenicity testing [PDF]
, 1997 Heterologous expression of mammalian bioactivation enzymes in bacteria can obviate the requirement for the addition of exogenous enzymes in bacterial genotoxicity testing.
Henry, Tracey
core +1 more source
Lenacapavir initiation with concomitant primidone: A case report with therapeutic drug monitoring
British Journal of Clinical Pharmacology, EarlyView.Lenacapavir (LEN), a first‐in‐class capsid inhibitor, has unique pharmacokinetics that enable twice‐yearly dosing. LEN is not extensively metabolized, although it is a substrate of CYP3A4, which introduces drug–drug interactions concerns. As adoption and implementation of LEN for treatment and prevention increase, additional guidance on concomitant ...
Aaron S. Devanathan +6 more
wiley +1 more source
Scientific Reports, 2021 Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450 (CYP) to ...
Daniela Presa +12 more
doaj +1 more source
7-Ethynylcoumarins: Selective Inhibitors of Human Cytochrome P450s 1A1 and 1A2 [PDF]
Chemical Research in Toxicology, 2012 To discover new selective mechanism-based P450 inhibitors, eight 7-ethynylcoumarin derivatives were prepared through a facile two-step synthetic route. Cytochrome P450 activity assays indicated that introduction of functional groups in the backbone of coumarin could enhance the inhibition activities toward P450s 1A1 and 1A2, providing good selectivity ...
Jiawang, Liu +7 more
openaire +2 more sources