Results 31 to 40 of about 150,542 (166)

Influence of cytochrome P450 and glutathione S transferase polymorphisms on response to nilotinib therapy among chronic myeloidleukemia patients from Pakistan

BMC Cancer, 2022
Background Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxification of anticancer drugs and carcinogens.
Samina Naz Mukry, Aneeta Shahni, Uzma Zaidi, Tahir Sultan Shamsi   +3 more
doaj   +1 more source

Metabolic enzyme gene polymorphisms predict the effects of antioxidant treatment on idiopathic male infertility

Asian Journal of Andrology, 2022
To explore the relationship between genetic polymorphisms of metabolic enzymes such as CYP1A1, CYP2D6, GSTM1, GSTT1, and GSTP1 and idiopathic male infertility. By observing the efficacy of antioxidants in the treatment of idiopathic male infertility, the
Hong-Yan Zhang, Yi Mu, Pan Chen, Dong-Dong Liu, Ke-Hang Chen, Qi Yu, Jun He, Fa Sun, Jun-Ping Xing, Kai-Fa Tang   +9 more
doaj   +1 more source

Evaluation of 2-Year-Old Intrasplenic Fetal Liver Tissue Transplants in Rats

Cell Transplantation, 2003
Liver cell transplantation into host organs like the spleen may possibly provide a temporary relief after extensive liver resection or severe liver disease or may enable treatment of an enzyme deficiency.
Amelie Lupp DR., Manfred Danz, Dieter Müller   +2 more
doaj   +1 more source

EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs

Sensors, 2009
In the present study, we characterized the kinetic parameters of 7-ethoxy-resorufin O-deethylation (EROD) and 7-methoxyresorufin O-demethylation (MROD) in hepatic microsomes from entire and castrated male pigs.
Vladimir Zlabek, Galia Zamaratskaia
doaj   +1 more source

In vivo effect of dried chicory root (Cichorium intybus L.) on xenobiotica metabolising cytochrome P450 enzymes in porcine liver [PDF]

, 2011
Cytochrome P450 (CYP) enzymes are widely studied for their involvement in metabolism of drugs and endogenous compounds. In porcine liver, CYP1A2,2Aand 2E1 are important for the metabolism of skatole.Feeding chicory roots to pigs is known to decrease the ...
Martin Krøyer Rasmussen, Galia Zamaratskaia, Bo Ekstrand, Ekstrand, Bo, Zamaratskaia, Galia, Rasmussen, Martin Krøyer, Sveriges lantbruksuniversitet., Zamaratskaia, Galia,   +7 more
core   +1 more source

Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

Scientific Reports, 2021
Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450 (CYP) to ...
Daniela Presa, Syed A. Khurram, Amir Z. A. Zubir, Sneha Smarakan, Patricia A. Cooper, Goreti R. Morais, Maria Sadiq, Mark Sutherland, Paul M. Loadman, James McCaul, Steven D. Shnyder, Laurence H. Patterson, Klaus Pors   +12 more
doaj   +1 more source

Relationship between the Genetic Polymorphisms of Phase I and II Drug-metabolizing Enzymes, as well as the Outcome of Chemotherapy in Advanced Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2011
Background and objective Currently available studies on the polymorphisms of drug-metabolizing enzymes and their chemotherapeutic effects in non-small cell lung cancer are not consistent.
Weiying LI, Wentao YUE, Xuehui YANG, Chunyan ZHANG, Yue WANG   +4 more
doaj   +1 more source

Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4

Frontiers in Pharmacology, 2022
Heterologous expression systems are important for analyzing the effects of genetic factors including single nucleotide polymorphisms on the functions of drug-metabolizing enzymes.
Yuu Miyauchi, Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Yoshitaka Tanaka, Shinji Takechi, Peter I. Mackenzie, Yuji Ishii   +9 more
doaj   +1 more source

Detection Techniques for Polycyclic Aromatic Hydrocarbons and Their Metabolites: A Review

physica status solidi (a), Volume 223, Issue 17, 9 September 2026.
Overview of the different techniques that can be used to detect polyclic aromatic hydrocarbons and their metabolites. Polycyclic aromatic hydrocarbons (PAHs) are a class of organic pollutants affecting the environment as well as individual health that has been linked to various diseases including cancer.
Martin Wolfgang Konrad, Jeroen Vanoirbeek, Patrick Wagner, Irene Taurino   +3 more
wiley   +1 more source

Expressão heteróloga de citocromo P450 356A1 de Crassostrea gigas e utilização para biomonitoramento ambiental [PDF]

, 2010
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010A ecotoxicologia é um dos ramos da ciência que cada vez mais ganha relevância internacional por
Silva, Christielly Rodrigues da
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