Results 41 to 50 of about 174,785 (211)
, 1993 Characterization of cytochrome P450 1A1 dependent monooxygenases in guinea pig heart revealed low rates of 7-ethoxyresorufin O-deethylation, which are markedly increased (20-fold) by treatment with β-naphthoflavone, a poly cyclic aromatic hydrocarbon ...
Gordon P. McCallum +3 more
core +1 more source
Chinese Journal of Lung Cancer, 2011 Background and objective Currently available studies on the polymorphisms of drug-metabolizing enzymes and their chemotherapeutic effects in non-small cell lung cancer are not consistent.
Weiying LI +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Heterologous expression systems are important for analyzing the effects of genetic factors including single nucleotide polymorphisms on the functions of drug-metabolizing enzymes.
Yuu Miyauchi +9 more
doaj +1 more source
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications
British Journal of Clinical Pharmacology, Volume 92, Issue 11, Page 3716-3732, November 2026.Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba +2 more
wiley +1 more source
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]
, 2009 In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Morio Yamada +3 more
core
Therapeutic Agents with AHR Inhibiting and NRF2 Activating Activity for Managing Chloracne
Antioxidants, 2018 Chloracne is the major skin symptom caused by dioxin intoxication. Dioxin activates the aryl hydrocarbon receptor (AHR)–cytochrome p450 1A1 (CYP1A1) system, generates oxidative stress, and induces hyperkeratinization of keratinocytes and sebocytes ...
Masutaka Furue +4 more
doaj +1 more source
Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings
Cancer Medicine, Volume 15, Issue 11, November 2026.ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo +2 more
wiley +1 more source
Molar ratio between cytochrome b5 and its reductases affects activity of cytochrome P450 1A1 towards Sudan I [PDF]
, 2017 Cytochromes P450 are an evolutionary very old group of enzymes. It spread into many isoforms that can be found in animals, plants, fungi, bacteria, and some viruses.
Netolický, Jakub
core
Association of CYP1A1 and CYP1B1 Gene Polymorphisms with TypeⅠEndometrial Cancer in Chinese Women
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the relationship of cytochrome P450 1A1 (CYP1A1) and cytochrome P450 1B1 (CYP1B1) gene polymorphism with the risk factors and susceptibility to typeⅠendometrial carcinoma in Chinese women.
HUANG Yu +3 more
doaj +1 more source
Detection Techniques for Polycyclic Aromatic Hydrocarbons and Their Metabolites: A Review
physica status solidi (a), Volume 223, Issue 17, 9 September 2026.Overview of the different techniques that can be used to detect polyclic aromatic hydrocarbons and their metabolites. Polycyclic aromatic hydrocarbons (PAHs) are a class of organic pollutants affecting the environment as well as individual health that has been linked to various diseases including cancer.
Martin Wolfgang Konrad +3 more
wiley +1 more source