Results 61 to 70 of about 150,542 (166)

Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor

Cell Transplantation, 2010
The first indication of hepatocyte transplantation is inborn liver-based metabolic disorders. Among these, urea cycle disorders leading to the impairment to detoxify ammonia and Crigler-Najjar Syndrome type I, a deficiency in the hepatic UDP ...
A. Bonora-Centelles, M. T. Donato, A. Lahoz, E. Pareja, J. Mir, J. V. Castell, M. J. Gómez-Lechón   +6 more
doaj   +1 more source

Genomic and Sex Contributions to Interindividual Variability in Pitavastatin Bioavailability

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 1, July 2026.
ABSTRACT Aim This study investigates pharmacogenetic determinants of pitavastatin disposition using a candidate‐gene approach. Methods In 48 healthy volunteers, 138 variants across 40 genes involved in drug metabolism and transport were analysed to assess their relationship with pitavastatin pharmacokinetics, alongside the influence of sex and ...
Eva González‐Iglesias, Sofía Moreno‐Pérez de Villar, Dolores Ochoa, Manuel Román, Jesús Novalbos, Samuel Martín‐Vilchez, Alejandro de Miguel, Francisco Abad‐Santos   +7 more
wiley   +1 more source

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, Volume 36, Issue 45, 5 June 2026.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Effect of lipoic acid on the expression of nonalcoholic fatty liver disease-associated genes in the liver of rats fed a hypercaloric choline-deficient diet

Journal of Advanced Biotechnology and Experimental Therapeutics
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver pathologies. Molecular mechanisms of NAFLD pathogenesis are complex and still require further clarification. Thus, this study aimed to investigate the impact of lipoic acid (
Anastasia Balakina, Nikita Trusov, Victor Tutelyan   +2 more
doaj   +1 more source

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies

Molecules, 2012
The cytochrome P450 (CYP) superfamily of heme enzymes play an important role in the metabolism of a large number of endogenous and exogenous compounds, including most of the drugs currently on the market. Inhibitors of CYP enzymes have important roles in
Maryam Foroozesh, Cheryl L. Klein Stevens, Jiawang Liu, Jayalakshmi Sridhar   +3 more
doaj   +1 more source

Sub-toxic events induced by truck speed-facilitated PM2.5 and its counteraction by epigallocatechin-3-gallate in A549 human lung cells

Scientific Reports, 2022
To distinguish the influences of fuel type and truck speed on chemical composition and sub-toxic effects of particulates (PM2.5) from engine emissions, biomarkers—interleukin-6 (IL-6), cytochrome P450 (CYP) 1A1, heme oxygenase (HO)-1, and NADPH-quinone ...
Shih Yu Pan, Kai Hsien Chi, Yen-Cih Wang, Wen-Chi Wei, Yune-Fang Ueng   +4 more
doaj   +1 more source

Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis

eFood, Volume 7, Issue 3, June 2026.
Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng, Yanqun Luo, Ying Gao, Yi Su, Haiping Xue, Tao Wu   +5 more
wiley   +1 more source

Characterization of the role of the cytochrome P450 1A1 in the metabolism of aflatoxin B1 in an engineered (CRISPR-Cas9) bovine liver cell line

, 2023
openAbstract: Aflatoxin B1 (AFB1) is a mycotoxin of particular concern due to its potent hepatotoxic, carcinogenic, and immunosuppressive properties, posing significant risks to human and animal health.
AMIN, SIDRA
core  

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution [PDF]

, 2014
© 2014 Janha et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Worwui, A, Shaheen, Seif O, Walton, Robert T., Worwui, Archibald, Walton, RT, Linton, Kenneth J, Sisay-Joof, F, Linton, KJ, Janha, Ramatoulie E, Kenneth J Linton, Shaheen, SO, Ramatoulie E Janha, Archibald Worwui, Fatoumatta Sisay-Joof, Seif O Shaheen, Robert T Walton, Janha, RE, Sisay-Joof, Fatoumatta   +17 more
core   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, Volume 15, Issue 2, Page 147-159, June 2026.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source