Results 61 to 70 of about 174,785 (211)

Expressão heteróloga de citocromo P450 356A1 de Crassostrea gigas e utilização para biomonitoramento ambiental [PDF]

, 2010
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Biotecnologia, Florianópolis, 2010A ecotoxicologia é um dos ramos da ciência que cada vez mais ganha relevância internacional por
Silva, Christielly Rodrigues da
core  

Effect of Guizhou red sour soup on hepatic lipid metabolism in high-fat diet rats based on proteomics [PDF]

Zhongguo niangzao
To investigate the effect and molecular mechanism of Guizhou red sour soup on hepatic lipid metabolism in rats with a high-fat diet, specific pathogen-free (SPF) grade male SD rats were continuously intervened with Guizhou red sour soup for 12 weeks. The
AO Xue, XIE Jingcheng, ZHAO Xiaojuan, YANG Hao, LIU Xiaoying, WANG Huiqun
doaj   +1 more source

Mechanism of Inhibition of Human Cytochrome P450 1A1 and 1B1 by Piceatannol [PDF]

Biomolecules and Therapeutics, 2008
Abstract − The resveratrol analogue piceatannol (3,5,3',4'-tetrahydroxy- trans-stilbene ) is a polyphenol present ingrapes and wine and reported to have anti-carcinogenic activities. To investigate the mechanism of anticarcino-genic activities of piceatannol, the effects on CYP 1 enzymes were determined in Escherichia coli membranes co-expressing ...
Ah-Reum Chae, Jae-Ho Shim, Young-Jin Chun   +2 more
openaire   +1 more source

Pharmacist's role in managing drug–drug interactions in people with HIV receiving antiretroviral therapy or HIV pre‐exposure prophylaxis: A focus on polypharmacy and transitions of care in the United States

British Journal of Clinical Pharmacology, EarlyView.
Shawnalyn W. Sunagawa, Elizabeth M. Sherman, Melissa Badowski, David B. Cluck, Spencer H. Durham, Joshua P. Havens, Emily Huesgen, Justin K. Ma, Roxane Rohani, Eric G. Sahloff, Kristy M. Shaeer, Radhika S. Polisetty   +11 more
wiley   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Heterologous expression and purification of rat cytochrome P450 1A1 [PDF]

, 2013
Cytochrome P450 1A1 belongs to "superfamily" of cytochromes P450 (CYPs). It is an extrahepatic enzyme that takes a part in detoxification metabolism of many xenobiotics but unfortunately also it is one of the most important representatives of CYPs ...
Vlková, Michaela
core  

Functional Characterization of Hepatocytes for Cell Transplantation: Customized Cell Preparation for Each Receptor

Cell Transplantation, 2010
The first indication of hepatocyte transplantation is inborn liver-based metabolic disorders. Among these, urea cycle disorders leading to the impairment to detoxify ammonia and Crigler-Najjar Syndrome type I, a deficiency in the hepatic UDP ...
A. Bonora-Centelles, M. T. Donato, A. Lahoz, E. Pareja, J. Mir, J. V. Castell, M. J. Gómez-Lechón   +6 more
doaj   +1 more source

DDIapp—A Web‐Based Application for Static Drug–Drug Interaction Assessment

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT In this work we describe the development of a web‐based application for static drug–drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models ...
Hirotaka Watase, Sylvie Klieber, Yorgos M. Psarellis, Nikhil Pillai, Panteleimon D. Mavroudis, Saroj Dhakal   +5 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Interaction of polycyclic aromatic hydrocarbons with human cytochrome P450 1A1: a CO flash photolysis study.

, 1996
The kinetics of CO binding to human cytochrome P450 1A1 was used to probe the interaction of polycyclic aromatic hydrocarbons (PAHs) with the membrane-bound P450 expressed in baculovirus-infected SF9 insect cells.
Koley, AP;Buters, JT;Robinson, RC;Markowitz, A;Friedman, FK
core   +1 more source