Results 81 to 90 of about 174,785 (211)
Effect of cytochrome b5 on enzyme kinetics of Sudan I hydroxylation catalyzed by human cytochrome P450 1A1 [PDF]
, 2019 Cytochromes P450 are the major xenobiotics converting enzymes. They are classified as mixed function monooxygenases (MFO). Isoform 1A1 is a extrahepatic form found mainly in the lung and other tissues.
Netolický, Jakub
core
Molecules, 2013 Honokiol is a bioactive component isolated from the medicinal herbs Magnolia officinalis and Magnolia grandiflora that has antioxidative, anti-inflammatory, antithrombotic, and antitumor activities.
Yong Yeon Cho +8 more
doaj +1 more source
Mechanisms of Gui Zhi Fu Ling Formula in Liver Fibrosis: Metabolomics and Gut Microbiota Analysis
eFood, Volume 7, Issue 3, June 2026.Our study was based on the efficacy of the phenotype in an animal model and used multi‐omics to explore the mechanism of action of the compound. We found that Gui Zhi Fu Ling Formula may ameliorate hepatic fibrosis potentially associated with increased hepatic EPA and the expression of gut Pseudomonas.
Xiaoliang Deng +5 more
wiley +1 more source
Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1
, 2015 The flavone backbone is a well-known pharmacophore present in a number of substrates and inhibitors of various P450 enzymes. In order to find highly potent and novel P450 family I enzyme inhibitors, an acetylene group was incorporated into six different ...
Lydia Mensah (1330989) +12 more
core +1 more source
Polymorphism of the cytochrome P-450 1A1 (A2455G) in women with breast cancer in Eastern Azerbaijan, Iran [PDF]
Iranian Journal of Basic Medical Sciences, 2014 Objective(s):Cytochrome P-450 1A1 is an important enzyme in the first phase of the metabolism of some carcinogens such as polycyclic aromatic hydrocarbons (PAHs), as well as estrogen.
Hakimeh Saadatian +4 more
doaj
Notulae Scientia Biologicae, 2019 The CYP family enzymes are broadly used as biomarkers because of their pattern of expression. This study describes the application of in silico tools to predict the physico-chemical characters of CYP1A protein from the catfish, Clarias gariepinus.
Muthuramalingam KARPAGAVALLI +5 more
doaj +1 more source
Induction of Cytochrome P450 1A1 in Mice by Repeated Oral Administration of Propranolol
Drug Metabolism and Pharmacokinetics, 2002 Pretreatment of adult male C57BL/6 mice with propranolol (PL, 100 mg/kg, p.o., once a day for five days) significantly increased PL N-deisopropylase activity and decreased PL 7-hydroxylase activity in liver microsomes, whereas PL 4- and 5-hydroxylase activities remained unchanged.
NARIMATSU, Shizuo +5 more
openaire +2 more sources
, 1994 Human cytochrome P450 (P450) 1A1 is primarily an extrahepatic enzyme and is important because of its roles in the activation of polycyclic hydrocarbons and other xenobiotic chemicals.
Guengerich, FP +4 more
core +1 more source
Cytochrome P450: Electron transfer and sensors
, 2022 S.1-11Electrochemical methods allow to characterize the reaction mechanism of the cytochrome P450 (CYP) enzymes by observing the electron transfer in real time.
Wollenberger, U. +2 more
core +1 more source
International Journal of Electrochemical Science, 2013 The antineoplastic alkaloid ellipticine is a prodrug, the pharmacological efficiency of which is dependent on its cytochrome P450 (CYP)- and/or peroxidase-mediated activation in target tissues.
Iveta Vranová +5 more
doaj +1 more source