Results 91 to 100 of about 174,785 (211)

Preparation of recombinant cytochrome P450 1A1 [PDF]

, 2011
5 Abstract Cytochrome P450 1A1 (CYP1A1) is one of the major isoforms of the cytochrome P450 superfamily. It is primarily an extrahepatic enzyme which is responsible for oxidation of many polycyclic aromatic hydrocarbons and other xenobiotics.
Dvořák, Martin
core  

Indole compounds from fermented soybean products activate the aryl hydrocarbon receptor to reduce liver injury

npj Science of Food
The consumption of stinky tofu, a traditional fermented soybean product from China, elevates the concentrations of indole and trimethylindole in murine feces and increases the levels of indole in serum, as well as indole in the liver.
Yanyun Wang, Leping Quan, Xiaomin Zheng, Qiang Hu, Xiaoli Huang, Yang Pu, Guangfa Xie, Qi Peng   +7 more
doaj   +1 more source

Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration

, 1995
Arsenic is a known pulmonary, hepatic, and skin carcinogen in humans and a known inducer of stress proteins. Consequently, the ability of arsenite (As3+) to modulate isozyme-selective cytochrome P450 (P450) dependent monooxygenase activities was ...
Christopher J. Sinal, Arnulfo Albores, John R. Bend, M. George Cherian   +3 more
core   +1 more source

Development of a new platform technology for plant Cytochrome P450 fusions [PDF]

, 2012
To date more than 15000 Cytochromes P450 have been identified and named so far, with one third belonging to the plant kingdom. This is a key biochemical resource, providing a wealth of biocatalysts covering a diverse range of chemistries ...
Schückel, Julia
core   +2 more sources

Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date

Molecules, 2017
The cytochrome P450 (CYP) family 1A enzymes, CYP1A1 and CYP1A2, are two of the most important enzymes implicated in the metabolism of endogenous and exogenous compounds through oxidation.
Jayalakshmi Sridhar, Navneet Goyal, Jiawang Liu, Maryam Foroozesh   +3 more
doaj   +1 more source

Functional co-expression of human oxidoreductase and cytochrome P450 1A1 in Saccharomyces cerevisiae results in increased EROD activity

, 1992
A cDNA coding for human oxidoreductase (NADPH-cytochrome P450 reductase) was expressed in S. cerevisiae on a high copy plasmid under control of a constitutive promoter.
Bärtsch, Stephan, Sengstag, Christian, Eugster, Hans-Pietro, Würgler, Friedrich E.   +3 more
core   +1 more source

Inhibition of Cytochrome P450 Activities by Extracts of Hyptis verticillata Jacq.: Assessment for Potential HERB-Drug Interactions

Molecules, 2018
Understanding the potential for adverse drug reactions (ADRs), from herb-drug interactions, is a key aspect of medicinal plant safety, with particular relevance for public health in countries where medicinal plant use is highly prevalent. We undertook an
David Picking, Bentley Chambers, James Barker, Iltaf Shah, Roy Porter, Declan P Naughton, Rupika Delgoda   +6 more
doaj   +1 more source

Identification and Analysis of Hub Genes in Diabetic Cardiomyopathy: Potential Role of Cytochrome P450 1A1 in Mitochondrial Metabolism and STZ-Induced Myocardial Dysfunction. [PDF]

Front Cardiovasc Med, 2022
Chen Y, Chen Y, Yang J, Wang Y, Shen W, Liu J, Yuan M, Hao X, Zhong L, Guo R.   +9 more
europepmc   +1 more source

Genetic Variations in Cytochrome P450 1A1 and 1B1 Genes in a Cohort of Patients from Iraq Diagnosed with Breast Cancer. [PDF]

Breast Cancer (Auckl), 2021
Ibrahem SQ, Ahmed HQ, Amin KM.
europepmc   +1 more source

Activation of Procarcinogens by Human Cytochrome-P450 Enzymes Expressed in Escherichia-Coli - Simplified Bacterial Systems for Genotoxicity Assays

, 1994
Bacterial assays were used to examine the activation of 14 known procarcinogens by cytochrome P450 (P450) enzyme(dagger). Human P450s 1A1, 1A2 and 3A4 were expressed in Escherichia coli with slight modification of their N-terminal sequences. Genotoxicity
Guengerich, FP, Gillam, Emj, Guo, ZY, Tukey, RH, Shimada, T, Sandhu, P   +5 more
core   +1 more source