Molar ratio between cytochrome b5 and its reductases affects activity of cytochrome P450 1A1 towards Sudan I [PDF]
, 2017 Cytochromes P450 are an evolutionary very old group of enzymes. It spread into many isoforms that can be found in animals, plants, fungi, bacteria, and some viruses.
Netolický, Jakub
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Genetic Variations in Cytochrome P450 1A1 and 1B1 Genes in a Cohort of Patients from Iraq Diagnosed with Breast Cancer. [PDF]
Breast Cancer (Auckl), 2021 Ibrahem SQ, Ahmed HQ, Amin KM.
europepmc +1 more source
Effect of cytochrome b5 on enzyme kinetics of Sudan I hydroxylation catalyzed by human cytochrome P450 1A1 [PDF]
, 2019 Cytochromes P450 are the major xenobiotics converting enzymes. They are classified as mixed function monooxygenases (MFO). Isoform 1A1 is a extrahepatic form found mainly in the lung and other tissues.
Netolický, Jakub
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Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor. [PDF]
Toxicol Appl Pharmacol, 2021 Wauchope S +7 more
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, 2007 Atypical kinetics of cytochrome P450 enzyme confounds the accurate prediction of drug metabolism from in vitro to in vivo in cDNA-expressed system. Microsomal membrane is reported to be a potential factor to modulate the cytochrome P450 (CYP) kinetics in
程婕, 刘勇, 杨凌
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Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1
, 2015 The flavone backbone is a well-known pharmacophore present in a number of substrates and inhibitors of various P450 enzymes. In order to find highly potent and novel P450 family I enzyme inhibitors, an acetylene group was incorporated into six different ...
Lydia Mensah (1330989) +12 more
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Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies. [PDF]
Dev Reprod, 2021 Kim JT +5 more
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Preparation of recombinant cytochrome P450 1A1 [PDF]
, 2011 5 Abstract Cytochrome P450 1A1 (CYP1A1) is one of the major isoforms of the cytochrome P450 superfamily. It is primarily an extrahepatic enzyme which is responsible for oxidation of many polycyclic aromatic hydrocarbons and other xenobiotics.
Dvořák, Martin
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Genetics and Molecular Biology, 2010 In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast.
Alfredo Santovito +3 more
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Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level
Nature CommunicationsMonitoring enzyme structural dynamics is essential for elucidating catalytic mechanisms, yet transient conformational fluctuations on microsecond-to-millisecond timescales remain challenging to resolve with conventional techniques.
Zhimin Fan +10 more
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