Results 101 to 110 of about 150,542 (166)

Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. [PDF]

Chem Res Toxicol, 2023
Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T.   +7 more
europepmc   +1 more source

Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration

, 1995
Arsenic is a known pulmonary, hepatic, and skin carcinogen in humans and a known inducer of stress proteins. Consequently, the ability of arsenite (As3+) to modulate isozyme-selective cytochrome P450 (P450) dependent monooxygenase activities was ...
Christopher J. Sinal, Arnulfo Albores, John R. Bend, M. George Cherian   +3 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Characterization and sexual dimorphic expression of Cytochrome P450 genes in gonads of the sea urchin (Mesocentrotus nudus)

Aquaculture Reports
Sea urchin (Mesocentrotus nudus) is a commercially significant mariculture species, with its gonads being the exclusive edible parts for humans. Identifying sex-related genes is an effective approach for elucidating the underlying molecular mechanisms of
Wei-Yi Su, Wei-Han Meng, Ling-Nan Kong, Shuai Chang, Jian Zhang, Ya-Qing Chang, Zhi-Hui Sun   +6 more
doaj   +1 more source

Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate. [PDF]

Drug Metab Dispos, 2020
Bart AG, Takahashi RH, Wang X, Scott EE.
europepmc   +1 more source

Bioactivation of Fluorinated 2-Aryl-benzothiazole Antitumor Molecules by Human Cytochrome P450s 1A1 and 2W1 and Deactivation by Cytochrome P450 2S1

, 2016
Both 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) and 5-fluoro-2-(3,4-dimethoxyphenyl)-benzothiazole (GW 610) contain the benzothiazole pharmacophore and possess potent and selective in vitro antitumor properties. Prior studies suggested the
F. Peter Guengerich (272072), Kai Wang (21246)   +1 more
core   +1 more source

Expression of recombinant human cytochrome P450 in Ames test strains for mutagenicity testing

, 1997
Heterologous expression of mammalian bioactivation enzymes in bacteria can obviate the requirement for the addition of exogenous enzymes in bacterial genotoxicity testing.
Henry, Tracey
core   +1 more source

Inhibition of Cytochrome P450 2E1, Cytochrome P450 3A6 and Cytochrome P450 2A6 by Citrus Essential Oils [PDF]

, 2010
Cytochrome P450 enzymes in the liver catalyze reactions involving the reduction of molecular oxygen and the oxidation of organic substrates. In some cases the resulting products may have the potential to contribute to oxidative stress within this organ ...
Williamson, Emily Ann, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Expression of modified human cytochrome P450 1A1 in Escherichia coli: Effects of 5' substitution, stabilization, purification, spectral characterization, and catalytic properties

, 1994
Human cytochrome P450 (P450) 1A1 is primarily an extrahepatic enzyme and is important because of its roles in the activation of polycyclic hydrocarbons and other xenobiotic chemicals.
Guengerich, FP, Gillam, Emj, Guo, ZY, Tukey, RH, Ohmori, S   +4 more
core   +1 more source

Study of Cytochrome P450 1A1 (T3801C) Single Nucleotide Polymorphism in Patients with Breast Cancer in Mazandaran Province-Northern Iran

Research in Molecular Medicine, 2015
 Background: Breast cancer is the first leading cause of cancer-related death in women. Pesticides which are excessively used in northern Iran are one of the most important risk factors for breast cancer incidence.
Ghazaleh Khalili, Ali Barzegar, Novin Nikbakhsh, Zarbakht Ansari-Pirsaraee   +3 more
doaj