Results 101 to 110 of about 174,785 (211)

Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of the aryl hydrocarbon receptor. [PDF]

Toxicol Appl Pharmacol, 2021
Wauchope S, Roy MA, Irvine W, Morrison I, Brantley E, Gossell-Williams M, Timme-Laragy AR, Delgoda R.   +7 more
europepmc   +1 more source

Ergosterol promotes the atypical kinetics of cytochrome P450 reductase and cytochrome P450-3A4 in recombinant yeast system

, 2007
Atypical kinetics of cytochrome P450 enzyme confounds the accurate prediction of drug metabolism from in vitro to in vivo in cDNA-expressed system. Microsomal membrane is reported to be a potential factor to modulate the cytochrome P450 (CYP) kinetics in
程婕, 刘勇, 杨凌
core  

Heterologous expression and isolation of human cytochromes P450 1A1/2 [PDF]

, 2011
Cytochromes P450 form a large family of hemoproteins. Some of them are responsible for the metabolism of endogenous substrates, but their major role is in detoxification of exogenous substrates (xenobiotics), some of them are activated to reactive ...
Milichovský, Jan
core  

Liver transplantation induces cytochrome P450 1A1 dependent monooxygenase activity in rat lung and kidney

, 1995
Although liver transplantation has been the subject of intensive investigation, comparatively little is known regarding the effects of this procedure on the metabolism of xenobiotics.
Christopher J. Sinal, Robert Zhong, John R. Bend, Lin-Fu Zhu, M. George Cherian   +4 more
core   +1 more source

Abstract Supplement HIV Glasgow 8–11 November 2026, Glasgow, UK/Virtual

Journal of the International AIDS Society, Volume 29, Issue S6, November 2026.
wiley   +1 more source

Chicken antibodies as a tool of cytochrome P450 immunodetection [PDF]

, 2011
Cytochrome P450 is an important enzyme which catalyzes a large amount of reactions of endogenous and exogenous metabolism. There are compounds which increase expression of this enzyme and it leads up to the carcinogen activation and cancer formation.
Mácová, Iva
core  

Benzo[a]pyrene Cytotoxicity Tolerance in Testicular Sertoli Cells Involves Aryl-hydrocarbon Receptor and Cytochrome P450 1A1 Expression Deficiencies. [PDF]

Dev Reprod, 2021
Kim JT, Park JE, Lee SJ, Yu WJ, Lee HJ, Kim JM.   +5 more
europepmc   +1 more source

Polymorphisms of cytochrome P450 1A1, glutathione s-transferases M1 and T1 genes in ouangolodougou (Northern Ivory Coast)

Genetics and Molecular Biology, 2010
In this study, the frequencies of CYP1A1, GSTM1, and GSTT1 gene polymorphisms were determined in 133 healthy individuals from Ouangolodougou, a small rural town situated in the north of the Ivory Coast.
Alfredo Santovito, Claudio Burgarello, Piero Cervella, Massimiliano Delpero   +3 more
doaj  

Real-time electrical monitoring of enzymatic catalytic dynamics at the single-molecule level

Nature Communications
Monitoring enzyme structural dynamics is essential for elucidating catalytic mechanisms, yet transient conformational fluctuations on microsecond-to-millisecond timescales remain challenging to resolve with conventional techniques.
Zhimin Fan, Zusen Chen, Zhengwen Gong, Sanjun Shi, Mingdi Xu, Xiaonan Feng, Yulu Liu, Ya Hu, Xiaoduo Chen, Guomao Zheng, Bintian Zhang   +10 more
doaj   +1 more source

Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. [PDF]

Chem Res Toxicol, 2023
Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, Guengerich FP, Shimada T.   +7 more
europepmc   +1 more source