Results 111 to 120 of about 174,785 (211)

Purification of multiple forms of cytochrome P450 from a human brain and reconstitution of catalytic activities

, 1993
The present study demonstrates the presence of multiple forms of cytochrome P450 (P450) in human brain obtained at autopsy, the purification of various isoforms to apparent homogeneity, and the monooxygenase activities in reconstituted systems ...
Boyd, M. R., Bhamre, S., Shankar, S. K., Anandatheerathavarada, H. K., Ravindranath, V.   +4 more
core   +1 more source

Modulation of human cytochrome P450 1A1-mediated oxidation of benzo[a]pyrene by NADPH:cytochrome P450 oxidoreductase and cytochrome b5

, 2014
OBJECTIVES: Cytochrome P450 (CYP) 1A1 located in the membrane of endoplasmic reticulum is the most important enzyme in both activation and detoxification of carcinogenic benzo[a]pyrene (BaP), in combination with microsomal epoxide hydrolase (mEH ...
Moserova, Michaela, Kroftova, Natalie, Adam, Vojtech, Sulc, Miroslav, Martinkova, Marketa, Eckschlager, Tomas, Stiborova, Marie, Kizek, Rene, Arlt, Volker M; id_orcid, Indra, Radek   +9 more
core   +4 more sources

Characterization of the role of the cytochrome P450 1A1 in the metabolism of aflatoxin B1 in an engineered (CRISPR-Cas9) bovine liver cell line

, 2023
openAbstract: Aflatoxin B1 (AFB1) is a mycotoxin of particular concern due to its potent hepatotoxic, carcinogenic, and immunosuppressive properties, posing significant risks to human and animal health.
AMIN, SIDRA
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Mechanism of enzymatic activation of carcinogens and drugs by the system of cytochrome P450 [PDF]

, 2015
13 Abstract An environmental pollutant and a human carcinogen benzo[a]pyrene (BaP) is after its activation with cytochrome P450 (CYP) able to covalently bind to DNA.
Indra, Radek
core  

Changes in Cytochrome P450-Dependent Activities and Isozyme Levels Following Cerebral Ischemia

, 1993
vii, 38 p.Cerebral ischemia has been shown to cause a number of metabolic changes including an accumulation of free fatty acids (Bazan, 1970; Kogure and Nakano, 1992).
Mullendore, Sean T.
core   +1 more source

Cytochrome P450 1A1 [PDF]

, 2020
openaire   +1 more source

Induction of Cytochromes P450 1a1 and 1b1 by Emodin in Human Lung Adenocarcinoma Cell Line Cl5

, 2008
Emodin (3-methyl-1,6,8-bihydroxyanthraquinone) is an active compound of many laxative herbal drugs. The present study aimed to determine the effects of emodin on cytochrome P450( P450)-dependent monooxygenases of human lung adenocarcinoma CL5 cells ...
YANG, PAN-CHYR, 楊泮池
core  

Characterization and sexual dimorphic expression of Cytochrome P450 genes in gonads of the sea urchin (Mesocentrotus nudus)

Aquaculture Reports
Sea urchin (Mesocentrotus nudus) is a commercially significant mariculture species, with its gonads being the exclusive edible parts for humans. Identifying sex-related genes is an effective approach for elucidating the underlying molecular mechanisms of
Wei-Yi Su, Wei-Han Meng, Ling-Nan Kong, Shuai Chang, Jian Zhang, Ya-Qing Chang, Zhi-Hui Sun   +6 more
doaj   +1 more source

Human Cytochrome P450 1A1 Adapts Active Site for Atypical Nonplanar Substrate. [PDF]

Drug Metab Dispos, 2020
Bart AG, Takahashi RH, Wang X, Scott EE.
europepmc   +1 more source

The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1.

, 1999
Metabolic activation of the K-region trans-8,9-diol of the highly carcinogenic hexacyclic aromatic hydrocarbon dibenzo[a,l]pyrene (DB[a,l]P) by human cytochrome P-450 (P450) 1A1 and 1B1 was investigated in Chinese hamster V79 cell lines expressing human ...
Kishiyama, S., Doehmer, J., Baird, W.M., Seidel, A., Luch, A., Greim, H.   +5 more
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