Results 51 to 60 of about 150,542 (166)

Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line

Viruses, 2020
In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an ...
Sabina Ranjit, Sunitha Kodidela, Namita Sinha, Subhash Chauhan, Santosh Kumar   +4 more
doaj   +1 more source

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

DDIapp—A Web‐Based Application for Static Drug–Drug Interaction Assessment

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT In this work we describe the development of a web‐based application for static drug–drug interaction (DDI) risk assessment in accordance with the International Council for Harmonization (ICH) M12 guidance. The app was built using the Shiny for Python framework and it employs a modular mathematical modeling structure that incorporates models ...
Hirotaka Watase, Sylvie Klieber, Yorgos M. Psarellis, Nikhil Pillai, Panteleimon D. Mavroudis, Saroj Dhakal   +5 more
wiley   +1 more source

Unveiling Gut Homeostasis Disruption in Sepsis: Towards an Integrated Mechanistic and Translational Roadmap

Cell Proliferation, Volume 59, Issue 8, August 2026.
Elucidating the contribution of gut‐organ axes will provide new insights for developing combined therapeutic strategies against sepsis‐associated multiple organ dysfunction. ABSTRACT Sepsis, a life‐threatening clinical syndrome precipitated by a maladaptive host response to infection, is associated with substantial morbidity and high mortality rates ...
Yichen Bao, Lin Qi, Guijun Zou, Xingpeng Yang, Yizhao Ma, Zhifu Li, Xiaohui Du, Pengyue Zhao   +7 more
wiley   +1 more source

Ultraviolet-B Exposure of Human Skin Induces Cytochromes P450 1A1 and 1B1 [PDF]

, 2000
The cytochromes P450 belong to a multigene superfamily and are responsible for the metabolic activation of both xenobiotics and endobiotics. The expression of cytochrome P450 genes in target cells is an important determinant of human susceptibility to ...
Katiyar, Santosh K., Matsui, Mary S., Mukhtar, Hasan   +2 more
core   +1 more source

Cytochrome P450: Electron transfer and sensors

, 2022
S.1-11Electrochemical methods allow to characterize the reaction mechanism of the cytochrome P450 (CYP) enzymes by observing the electron transfer in real time.
Wollenberger, U., Scheller, F.W., Yarmana, A.   +2 more
core   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, Volume 293, Issue 15, Page 4554-4577, August 2026.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Effect of Guizhou red sour soup on hepatic lipid metabolism in high-fat diet rats based on proteomics [PDF]

Zhongguo niangzao
To investigate the effect and molecular mechanism of Guizhou red sour soup on hepatic lipid metabolism in rats with a high-fat diet, specific pathogen-free (SPF) grade male SD rats were continuously intervened with Guizhou red sour soup for 12 weeks. The
AO Xue, XIE Jingcheng, ZHAO Xiaojuan, YANG Hao, LIU Xiaoying, WANG Huiqun
doaj   +1 more source

Lessons From Astaxanthin Therapy to Combat Oral Premalignant and Malignant Lesions: A Narrative Review

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Oral cancer is one of the most common head and neck malignancies and remains associated with high morbidity, mortality, and treatment‐related toxicity. Despite advances in surgery, radiotherapy, and chemotherapy, there is still a need for safer adjunctive therapies with better therapeutic potential.
Reza Arefnezhad, Zhina Mohamadi, Shervin Shahianjahromi, Amirali Fallahian, Maryam Ashrafi, Armin Nikdehqan, Mitra Saeedi Valashani, Reza Nasiri, Fatemeh Zeinali, Hossein Fatemian, Niloofar Sefati, Fatemeh Rezaei‐Tazangi, Marziye Ranjbar Tavakoli   +12 more
wiley   +1 more source

Localization and induction of cytochrome P450 1A1 and aryl hydrocarbon hydroxylase activity in rat nasal mucosa.

, 1993
Cytochrome P450 1A1 was localized immunohistochemically and benzo[a]pyrene hydroxylase activity was identified in situ by means of fluorescence histochemistry in the nasal mucosa of untreated, 3-methylcholanthrene-treated or Aroclor 1254-treated rats ...
J Baron, F P Guengerich, J M Voigt
core   +1 more source