Results 1 to 10 of about 773 (131)

Assessment of glutathione S-transferaseM1 (GSTM1) and its polymorphisms GSTM1 null in the response to treatment with chemotherapy in advanced ovarian carcinoma [PDF]

Einstein (São Paulo), 2011
Objective: To assess if the genotype of the glutathione S-transferaseM1 (GSTM1) enzyme and its GSTM1 null polymorphism can influencethe response to chemotherapeutic treatment of advanced ovariancancer.
Gilberto Kendi Takeda, Daniela Batista Leite, Michele Gilvana Junqueira, Luiz Augusto Freire Lopes, Ismael Dale Cotrim Guerreiro da Silva, Fausto Farah Baracat   +5 more
doaj   +9 more sources

GSTM1 Suppresses Cardiac Fibrosis Post-Myocardial Infarction Through Inhibiting Lipid Peroxidation and Ferroptosis

Military Medical Research
Background Cardiac fibrosis following myocardial infarction (MI) drives adverse ventricular remodeling and heart failure, with cardiac fibroblasts (CFs) playing a central role.
Hong Ma, Shuo Yu, Lan Xie
exaly   +2 more sources

Hypomethylation of the GSTM1 Promoter Is Associated With Ovarian Endometriosis

Human Reproduction, 2019
Is the methylation status of the glutathione S-transferase M1 (GSTM1) promoter region altered in patients with ovarian endometriosis, and does this affect the expression of GSTM1 in their endometrial tissues?The promoter region of GSTM1 was significantly hypomethylated in the ectopic and eutopic endometrium of patients with ovarian endometriosis and ...
Shan Kang
exaly   +3 more sources

Evaluation of associations of GSTM1/GSTT1 null genotypes with the susceptibility to age-related macular degeneration: A meta-analysis [PDF]

Scripta Medica, 2021
Background: The relationship between glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null genotypes (homozygotes for the null alleles) and the susceptibility to age-related macular degeneration (ARMD) have been reported and revealed inconsistent ...
Saadat Mostafa
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Annals of Human Biology, 2021
Background Essential hypertension (EH) results from a complex interaction between environmental factors and an individual’s genetic background. Aim To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH.
Sanaa Nassereddine, Rachida Habbal, Yaya Kassogue, Ait Boujmia Oum Kaltoum, Korchi Farah, Haraka Majda, Abou Elfath Rhizlane, Sellama Nadifi, Hind Dehbi   +8 more
doaj   +1 more source

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus [PDF]

Biochemical Journal, 1993
We describe the identification of the GSTM1 null, GSTM1 A, GSTM1 B and GSTM1 A,B polymorphisms at the glutathione S-transferase GSTM1 locus using a single-step PCR method. Target DNA was amplified using primers to intron 6 and exon 7 with site-directed mutagenesis being used to introduce a restriction site in DNA amplified from GSTM1 *A, thereby ...
A A, Fryer, L, Zhao, J, Alldersea, W R, Pearson, R C, Strange   +4 more
openaire   +2 more sources

Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma

Canadian Respiratory Journal, 2022
Background. Toluene diisocyanate (TDI) causes occupational asthma by generating oxidative stress, leading to tissue injury and inflammation. Glutathione transferases (GSTs) are detoxifying enzymes that eliminate oxidative stress.
Jong-Uk Lee, Ji-Yeon Jeong, Min Kyung Kim, Sun A. Min, Jong-Sook Park, Choon-Sik Park   +5 more
doaj   +1 more source

Genetic Polymorphisms of Glutathione S-Transferase and Risk of Acute Myeloid Leukemia: Case-Control Study and Meta-Analysis [PDF]

Middle East Journal of Cancer, 2020
Background: Acute myeloid leukemia (AML) is a complex disease that is linked to genetic and environmental factors. The gluthatione S-transferase (GST) is a family of enzymes that play a crucial role in the detoxification of carcinogens.
Oum Kaltoum Ait Boujmia, Sellama Nadifi, Hind Dehbi, Yaya Kassogue, Mouna Lamchahab, Asma Quessar   +5 more
doaj   +1 more source

The Catalytic Activity of GSTM1 In vitro is Independent of MAPK8

Drug Metabolism Letters, 2021
Background: Glutathione S-transferases (GSTs) are phase II metabolic enzymes crucial for the metabolism of electrophilic drugs. Additionally, several GST isoforms are involved in protein- protein interaction with mitogen-activated protein kinases (MAPKs), modulating apoptosis pathways.
Robin, Shannon Kristell Denise, Ben Hassine, Khalil, Mlakar, Simona, Mlakar, Vid, Ansari Djaberi, Marc Georges, Uppugunduri Satyanarayana, Chakradhara Rao   +5 more
openaire   +3 more sources