Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis [PDF]
Journal of Advanced Periodontology and Implant DentistryIntroduction: Periodontitis is a prevalent inflammatory disease influenced by both genetic and environmental factors. Among genetic determinants, polymorphisms in oxidative stress-related g e n e s — p a r t i c u l a r l y GSTM1, GSTT1, and GSTP1 ...
Paria Motahari, Negin Neshanifard
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Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma [PDF]
Arhiv za Higijenu Rada i ToksikologijuEarlier tissue-based studies report heterogeneous CYP and GST protein expression in non-small cell lung cancer (NSCLC), but simultaneous assessment of phase I and II enzymes in paired tumour and peripheral normal tissues remains limited and their ...
Kılıç Murat +6 more
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Beyond HLA: an exploratory pilot study of non-HLA antibodies, HLA sensitization, and GSTT1 genotype in platelet transfusion refractoriness [PDF]
Frontiers in ImmunologyObjectivesPlatelet transfusion refractoriness (PTR) is a common and clinically challenging condition with complex underlying mechanisms. Human leukocyte antigen (HLA) alloimmunization is the principal cause of immune PTR (iPTR), whereas non-HLA ...
Jun Qi +10 more
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Association of GSTM1 and GSTT1 Null Genotypes with Toluene Diisocyanate-Induced Asthma
Canadian Respiratory Journal, 2022 Background. Toluene diisocyanate (TDI) causes occupational asthma by generating oxidative stress, leading to tissue injury and inflammation. Glutathione transferases (GSTs) are detoxifying enzymes that eliminate oxidative stress.
Jong-Uk Lee +5 more
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Nullity of GSTM1 and GSTT1 Associated with CD4+ T Cells in HIV-Positive Patients from Southern Brazil [PDF]
AntioxidantsScientific evidence has suggested, in most cases, that nullity of the GSTM1 and GSTT1 genes is associated with worse pathological outcomes and viral infections.
Marcela Gonçalves Trevisan +5 more
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Electronic Physician, 2022 Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S ...
Mohammad hosain Afrand
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Evaluation of associations of GSTM1/GSTT1 null genotypes with the susceptibility to age-related macular degeneration: A meta-analysis [PDF]
Scripta Medica, 2021 Background: The relationship between glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null genotypes (homozygotes for the null alleles) and the susceptibility to age-related macular degeneration (ARMD) have been reported and revealed inconsistent ...
Saadat Mostafa
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Genetic Polymorphisms of Glutathione S-Transferase and Risk of Acute Myeloid Leukemia: Case-Control Study and Meta-Analysis [PDF]
Middle East Journal of Cancer, 2020 Background: Acute myeloid leukemia (AML) is a complex disease that is linked to genetic and environmental factors. The gluthatione S-transferase (GST) is a family of enzymes that play a crucial role in the detoxification of carcinogens.
Oum Kaltoum Ait Boujmia +5 more
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BMC Medical Genetics, 2020 Background Glutathione S-transferases play a key role in the detoxification of persistent oxidative stress products which are one of several risks factors that may be associated with many types of disease processes such as cancer, diabetes, and ...
Herman Karim Sombié +16 more
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In silico search for regulatory genes associated with lung and liver disease in Cystic Fibrosis [PDF]
Network Biology, 2021 The pathogenesis of Cystic Fibrosis (CF) airway disease is not well understood. CF is an autosomal recessive monogenic genetic disease. It affects the exocrine glands, which normally produce thin secretions such as mucus, sweat and tears.
Rafat Ali +2 more
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