Results 21 to 30 of about 9,099 (167)

Absence of Glutathione S-Transferase Theta 1 Gene Is Significantly Associated With Breast Cancer Susceptibility in Pakistani Population and Poor Overall Survival in Breast Cancer Patients: A Case-Control and Case Series Analysis

Frontiers in Oncology, 2021
PurposeDeletion of Glutathione S-Transferase Theta 1 (GSTT1) encoding gene is implicated in breast cancer susceptibility, clinical outcomes, and survival. Contradictory results have been reported in different studies. The present investigation based on a
Sadia Ajaz, Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali, Aisha Siddiqa, Muhammad Ali Memon, Sadaf Firasat, Aiysha Abid, Shagufta Khaliq   +8 more
doaj   +1 more source

Evaluation of Glutathione S-transferase T1 (GSTT1) deletion polymorphism on type 2 diabetes mellitus risk in a sample of Yazdian females in Yazd, Iran

Electronic Physician, 2014
Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S ...
Saeedhossein Khalilzadeh, Mohammadhosain Afrand, Seyed Khalil Froozan-Nia, Mohammad Hasan Sheikhha   +3 more
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

Polymorphisms in biotransformation and DNA repair genes, and survival on head and neck squamous cell carcinoma

Brazilian Journal of Oncology, 2021
Objective: This study analyzed the association between xenobiotic metabolism and DNA repair gene polymorphisms and overall survival (OS) and disease-free survival (DFS) in patients diagnosed with HNSCC in a Brazilian population.
Osmar Amorim Novais, Débora Diniz Bezerra, Ana Angélica Leal Barbosa, Cintia Rodrigues Marques, Marcílio Ferreira, Fabrício Rios-Santos, Thiago Magalhães da-Silva   +6 more
doaj   +1 more source

Glutathione S-transferase (GSTT1 and GSTP1) Polymorphisms Improves the Short- and Long-Term Efficacy of Concurrent Chemoradiotherapy in Advanced Ovarian Cancer [PDF]

Molecular Biology & Nanomedicine, 2020
Over the past four decades, patients with advanced ovarian cancer (OC) has enjoyed greatly improved survival rate considering advances in combined chemotherapy with platinum and paclitaxel.
Xiao Xu, Zhuo Zhong, Dong-Mei Dou, Fenfen Li   +3 more
doaj   +1 more source

Evaluation of glutathione S-transferase T1 deletion polymorphism on type 2 diabetes mellitus risk in Zoroastrian females in Yazd, Iran

Indian Journal of Endocrinology and Metabolism, 2015
Background: There has been much interest in the role of free radicals and oxidative stress in the pathogenesis of diabetes mellitus (DM). The aim of this study was to assess the possible association between genetic polymorphisms of the glutathione S ...
Mohammadhosain Afrand, Saeedhossein Khalilzadeh, Nasrollah Bashardoost, Mohammad Hasan Sheikhha   +3 more
doaj   +1 more source

Expression of glutathione S-transferase T1 (GSTT1) in human brain tumours [PDF]

, 2006
Glutathione S-transferases (GSTs) play a central role in a number of metabolic processes. Glutathione S-transferase T1 (GSTT1) is a polymorphic cytosolic enzyme and a member of the theta class of GSTs.
Bock, Hans-Christoph, Schulz, Thomas G., Diedrich, A., Koenig, Fatima Barbara, Ludwig, H.-C., Quondamatteo, Fabio, Herken, R.   +6 more
core   +3 more sources

GSTT1 and GSTM1 null variants in Mestizo and Amerindian populations from northwestern Mexico and a literature review

Genetics and Molecular Biology, 2017
The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers.
Luz Elena Palma-Cano, Emilio J. Córdova, Lorena Orozco, Angélica Martínez-Hernández, Miguel Cid, Irene Leal-Berumen, Angel Licón-Trillo, Ruth Lechuga-Valles, Mauricio González-Ponce, Everardo González-Rodríguez, Verónica Moreno-Brito   +10 more
doaj   +1 more source

GSTT1 null genotype frequency in a Turkish population.

, 2021
In humans; glutathione-S-transferases (GSTs) are involved in the detoxification of xenobiotics. A deletion polymorphism in the glutathione S-transferase Theta 1 gene (GSTT1 null genotype) is associated with an increased risk of certain forms of cancer ...
Oke, B, Akbas, F, Berkkan, H, Aydin, Müge   +3 more
core   +1 more source

Distribution of polymorphic genotypes of GSTP1, GSTM1 and GSTT1 and their association with primary open-angle glaucoma

Journal of Ophthalmology, 2018
Background: The role of genetic factors in the development of primary open-angle glaucoma (POAG) has been confirmed previously. Activation of oxidative stress with a reduction in the activity of glutathione S transferase (GST) family enzymes is a major ...
S.O. Rykov, A.V. Burdei, S.V. Ziablitsev, S.Iu. Mogilevskyy   +3 more
doaj   +1 more source