Results 11 to 20 of about 9,099 (167)

GSTT1 deletion is related to polycyclic aromatic hydrocarbons-induced DNA damage and lymphoma progression.

PLoS ONE, 2014
The interrelationship between genetic susceptibility and carcinogenic exposure is important in cancer development. Polymorphisms in detoxification enzymes of the glutathione-S-transferases (GST) family are associated with an increased incidence of ...
Fan Yang, Jie Xiong, Xiao-E Jia, Zhao-Hui Gu, Jing-Yi Shi, Yan Zhao, Jun-Min Li, Jun-Min Li, Sai-Juan Chen, Wei-Li Zhao   +9 more
doaj   +2 more sources

Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Annals of Human Biology, 2021
Background Essential hypertension (EH) results from a complex interaction between environmental factors and an individual’s genetic background. Aim To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH.
Sanaa Nassereddine, Rachida Habbal, Yaya Kassogue, Ait Boujmia Oum Kaltoum, Korchi Farah, Haraka Majda, Abou Elfath Rhizlane, Sellama Nadifi, Hind Dehbi   +8 more
doaj   +2 more sources

GSTT1/GSTM1 deficiency aggravated cisplatin-induced acute kidney injury via ROS-triggered ferroptosis

Frontiers in Immunology
IntroductionCisplatin is a widely used chemotherapeutic agent prescribed to treat solid tumors. However, its clinical application is limited because of cisplatin- induced nephrotoxicity.
Peipei Li, Peipei Li, Peipei Li, Peipei Li, Duopin Li, Duopin Li, Duopin Li, Duopin Li, Yanfang Lu, Yanfang Lu, Yanfang Lu, Yanfang Lu, Shaokang Pan, Shaokang Pan, Shaokang Pan, Shaokang Pan, Fei Cheng, Fei Cheng, Fei Cheng, Fei Cheng, Shen Li, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Xiaonan Zhang, Jinling Huo, Jinling Huo, Jinling Huo, Jinling Huo, Dongwei Liu, Dongwei Liu, Dongwei Liu, Dongwei Liu, Zhangsuo Liu, Zhangsuo Liu, Zhangsuo Liu, Zhangsuo Liu   +36 more
doaj   +2 more sources

Cytochrome P450 (CYP) and glutathione S-transferases (GST) polymorphisms (CYP1A1, CYP1B1, GSTM1, GSTP1 and GSTT1) and urinary levels of 1-hydroxypyrene in Turkish coke oven workers [PDF]

Genetics and Molecular Biology, 2007
Genetic polymorphisms of xenobiotic metabolizing enzymes have been associated with cancer risk. We evaluated the influences of genetic polymorphisms of polycyclic aromatic hydrocarbon (PAH) metabolizing enzymes on urinary 1-hydroxypyrene (1-OHP ...
Ahmet Oguz Ada, Meltem Yilmazer, Sinan Suzen, Canan Demiroglu, Ali Eba Demirbag, Sibel Efe, Yavuz Alemdar, Sema Burgaz, Mumtaz Iscan   +8 more
doaj   +2 more sources

Association between GSTM1 and GSTT1 allelic variants and head and neck squamous cell cancinoma.

PLoS ONE, 2012
BackgroundsGSTM1 and GSTT1 are involved in the detoxification of carcinogens such as smoking by-products, and polymorphisms in these two genes with a result of loss of enzyme activity may increase risk of carcinogenesis.
Yang Zhang, Yuanyuan Ni, Hao Zhang, Yongchu Pan, Junqing Ma, Lin Wang   +5 more
doaj   +2 more sources

Nullity of GSTT1/GSTM1 related to pesticides is associated with Parkinson's disease [PDF]

Arquivos de Neuro-Psiquiatria, 2013
Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence
Marcela Augusta de Souza Pinhel, Caroline Leiko Sado, Gabriela dos Santos Longo, Michele Lima Gregorio, Gisele Sousa Amorim, Greiciane Maria da Silva Florim, Camila Montoro Mazeti, Denise Poltronieri Martins, Fabio de Nazare Oliveira, Marcelo Arruda Nakazone, Waldir Antonio Tognola, Doroteia Rossi Silva Souza   +11 more
doaj   +2 more sources

Null genotypes of GSTM1 and GSTT1 and endometriosis risk: a meta-analysis of 25 case-control studies.

PLoS ONE, 2014
Endometriosis is one of the most frequent benign gynecological disorders. Numerous studies have shown an association between GSTM1 and/or GSTT1 polymorphisms and endometriosis susceptibility. However, these associations remain inconclusive.
Haili Zhu, Jiming Bao, Shuguang Liu, Qing Chen, Hong Shen   +4 more
doaj   +2 more sources

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients. [PDF]

Br J Clin Pharmacol
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Laffitte Redondo C, Bourdin V, Ait Tayeb AEK, Benaboud S, Martins I, Joyau C, Benhamida M, Sermet-Gaudelus I, Martin C, Burgel PR, Verstuyft C, Chouchana L, Ayme-Dietrich E.   +12 more
europepmc   +2 more sources

RAF1 Promotes Gstt1‐Mediated Ferroptosis by Promoting KDM1A Recruitment to Facilitate Pilocarpine‐Induced Acute Seizure‐Associated Neuronal Injury [PDF]

CNS Neurosci Ther
In the hippocampus of mice with pilocarpine‐induced acute seizures and in glutamate‐treated neuronal cell lines, the mRNA and protein levels of RAF1 were significantly increased. RAF1 interacts with the KDM1A and recruits it to the promoter of Gstt1, thereby inhibiting the transcription of Gstt1.
Lu T, Feng Y, Chen X, Shen L, Liu M, Jia Y.   +5 more
europepmc   +2 more sources

Non-HLA Antibody-Associated Hyperacute Allograft Rejection Following Lung Transplantation. [PDF]

Pediatr Transplant
ABSTRACT Background Pediatric‐onset pulmonary hypertension (PH) is a rare, progressive pulmonary vascular disease associated with high mortality. In cases unresponsive to pharmacological therapy with a severe cardiorespiratory phenotype, lung transplantation (LT) remains the final treatment option. Although LT for pediatric PH is considered a procedure
Karolak JA, Melicoff E, Varghese NP, Szafranski P, Bölükbaşı EY, McHugh EE, Nicholas S, Jindra P, Hicks J, Austin ED, Stankiewicz P, Mallory GB.   +11 more
europepmc   +2 more sources