Redox Biology, 2023 Glutathione S-transferase P1(GSTP1) is known for its transferase and detoxification activity. Based on disease-phenotype genetic associations, we found that GSTP1 might be associated with bone mineral density through Mendelian randomization analysis ...
Shi-Gui Yan, Minjun Yao, Jianqiao Hong
exaly +4 more sources
Identification of Crocin I as a positive modulator of GSTP1 with potential relevance to prostate cancer [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryGlutathione S-transferase Pi 1 (GSTP1) is frequently silenced in prostate adenocarcinoma (PRAD), yet whether its residual catalytic activity can be chemically enhanced is largely unexplored.
Hao Qin +7 more
doaj +2 more sources
Advanced Science, 2023 Glutathione S‐transferase pi (GSTP1), a phase II detoxification enzyme, is known to be overexpressed and mediates chemotherapeutic resistance in lung cancer.
Si‐Qi Wang +8 more
doaj +2 more sources
STAT3/POSTN/GSTP1/JNK Axis Orchestrates Ferroptosis in Nucleus Pulposus Cells: A Potential Therapeutic Target for Intervertebral Disc Degeneration [PDF]
NeurospineObjective This study aimed to investigate the role of the STAT3/POSTN/GSTP1/JNK axis in ferroptosis and extracellular matrix (ECM) metabolic imbalance in nucleus pulposus cells (NPCs) during intervertebral disc degeneration (IDD) and to explore ...
Zhaoheng Wang +5 more
doaj +2 more sources
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma [PDF]
Arhiv za Higijenu Rada i ToksikologijuEarlier tissue-based studies report heterogeneous CYP and GST protein expression in non-small cell lung cancer (NSCLC), but simultaneous assessment of phase I and II enzymes in paired tumour and peripheral normal tissues remains limited and their ...
Kılıç Murat +6 more
doaj +2 more sources
Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis [PDF]
Journal of Advanced Periodontology and Implant DentistryIntroduction: Periodontitis is a prevalent inflammatory disease influenced by both genetic and environmental factors. Among genetic determinants, polymorphisms in oxidative stress-related g e n e s — p a r t i c u l a r l y GSTM1, GSTT1, and GSTP1 ...
Paria Motahari, Negin Neshanifard
doaj +2 more sources
Analytical study of influence of polymorphisms of VEGF+936T/C, ACE ID, TNF308G/A, and GSTP1 genes on retinopathy of prematurity progression/regression [PDF]
Indian Journal of OphthalmologyPurpose: The purpose of this study is to analyze the genetic polymorphisms of specific genes— VEGF +936T/C, ACE ID, TNF 308G/A, and GSTP1—on the progression or regression of retinopathy of prematurity (ROP) in premature infants.
S I Thasneem Suraiya +4 more
doaj +2 more sources
PLoS ONE, 2021 GSTP1 is a member of the Glutathione-S-transferase (GST) family silenced by CpG island DNA hypermethylation in 90-95% of prostate cancers. However, prostate cancers expressing GSTP1 have not been well characterized.
Igor Vidal +15 more
doaj +1 more source
Glutathione S-transferase (GSTT1 and GSTP1) Polymorphisms Improves the Short- and Long-Term Efficacy of Concurrent Chemoradiotherapy in Advanced Ovarian Cancer [PDF]
Molecular Biology & Nanomedicine, 2020 Over the past four decades, patients with advanced ovarian cancer (OC) has enjoyed greatly improved survival rate considering advances in combined chemotherapy with platinum and paclitaxel.
Xiao Xu +3 more
doaj +1 more source
Analytical Cellular Pathology, 2023 Hypoxic conditions are a typical extrinsic factor for the modification of trophoblast biological functions, including cell proliferation, migration, and invasion.
Lingjuan Chen +4 more
doaj +1 more source