Results 41 to 50 of about 16,641 (168)

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source

Summary of meta-analysis of GSTM1, GSTT1 and GSTP1 polymorphisms and PCa risk.

, 2012
OR, odds ratio; CI, confidence interval.*GSTP1 the total result of after excluding three researches deviated from Hardy-Weinberg equilibrium (HWE).aGSTM1 (−/−) and GSTT1 (−/−) vs.
Mancheng Gong (117913), Wenjing Dong (117921), Ruihua An (117936), Yangyang Xu (117932), Zhirong Shi (117928), Wenjun Ni (117934)   +5 more
core   +1 more source

GSTP1 improves CAR-T cell proliferation and cytotoxicity to combat lymphoma

Frontiers in Immunology
IntroductionThe exhaustion of chimeric antigen receptor T cells (CAR-T) hampers the efficacy of CAR-T cell therapy. Persistent antigen stimulation in T cells results in a surge of intracellular reactive oxygen species (ROS).
Guangsong Xu, Jiani Wang, Yuliang Qu, Jing Ning, Yanting Zhang, Guangxian Xu, Yunxia Shi, Ying Li, Le Guo, Xuebo Han, Hongxia Wang   +10 more
doaj   +1 more source

High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

GSTP1 CpG Island Hypermethylation Is Responsible for the Absence of GSTP1 Expression in Human Prostate Cancer Cells

, 2001
GSTP1 CpG island hypermethylation is the most common somatic genome alteration described for human prostate cancer (PCA); lack of GSTP1 expression is characteristic of human PCA cells in vivo.
Metin Tascilar, van Rees, Bastian, Lee, Byron H, Gage, Wesley R, Wesley R. Gage, G. Steven Bova, Ravi Veeraswamy, Tascilar, Metin, Kekule Asgari, William B. Isaacs, Freije, Diha, Angelo M. De Marzo, Lee, Wen-Hsiang, William G. Nelson, Bova, G. Steven, Byron H. Lee, Asgari, Kekule, Brooks, James D, DeWeese, Theodore L, Veeraswamy, Ravi, Theodore L. DeWeese, Nelson, William G, Diha Freije, Isaacs, William B, Lin, Xiaohui, Bastian van Rees, Wen-Hsiang Lee, De Marzo, Angelo M, Wouter J. Vles, Vles, Wouter J, James D. Brooks, Xiaohui Lin   +31 more
core   +1 more source

Long non‐coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets

British Journal of Pharmacology, EarlyView.
Long non‐coding RNAs (lncRNAs), a broad class of non‐protein‐coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post‐transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory ...
Charlie Leboff, Pamela Calle‐Mendoza, Maria Hatziapostolou, Christos Polytarchou   +3 more
wiley   +1 more source

Glutathione transferase P1 is modified by palmitate.

PLoS ONE
Glutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling.
Vanessa Marensi, Megan C Yap, Yuhuan Ji, Cheng Lin, Luc G Berthiaume, Elaine M Leslie   +5 more
doaj   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

GSTM1, GSTP1, and GSTT1 Genetic Variability in Turkish and Worldwide Populations

, 2014
ObjectiveGlutathione S-transferase (GST) variants have been widely investigated to better understand their role in several pathologic conditions. To our knowledge, no data about these genetic polymorphisms within the Turkish population are currently ...
Mehmet Karaca, Karaca, Sefayet, Tomris Cesuroglu, Erge, Sema, Polimanti, Renato, Renato Polimanti, Cesuroglu, Tomris, Karaca, Mehmet, Cesuroglu, Tomris; id_orcid, Sema Erge, Sefayet Karaca   +10 more
core   +2 more sources