Results 61 to 70 of about 16,641 (168)

Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo, George Rebello, Veron Ramsuran   +2 more
wiley   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Abstract 2557: GSTP1 is a determinant of temozolomiode resistance in human glioblastoma cells

, 2010
Temozolomide (TMZ) is a methylating agent used in first-line treatment of malignant gliomas and melanomas. Unfortunately, its use is limited by multifaceted resistance mechanisms.
Simendra Singh, Francis Ali-Osman
core   +1 more source

Plasma Interleukin‐10 Levels and IL10 Genetic Variants Are Associated With Clinical Outcomes in Patients With Severe COVID‐19 Treated With Corticosteroids

Journal of Medical Virology, Volume 98, Issue 11, November 2026.
ABSTRACT We aimed to evaluate the association between IL10 variants and plasma IL‐10 levels and clinical outcomes in patients with severe COVID‐19 treated with corticosteroids. We studied 944 patients with severe COVID‐19 who were treated with corticosteroids.
Ingrid Fricke‐Galindo, Francisco M. Ortega‐Villafuerte, Gloria Pérez‐Rubio, Ivette Buendía‐Roldán, Julián Ramírez‐Bello, Azael A. Castillo Morales, Leslie Chávez‐Galán, Rafael de Jesús Hernández‐Zenteno, Espiridión Ramos‐Martínez, Salvador García‐Carmona, Daniela Josefina Cataneo‐Piña, Nora Edith Bautista‐Félix, Ramcés Falfán‐Valencia   +12 more
wiley   +1 more source

Results of meta-analysis of GSTP1 AG vs. AA polymorphism.

, 2013
Results of meta-analysis of GSTP1 AG vs. AA polymorphism.
Josephine Aguilar (462238), Rui Chen (95310), Tong Meng (462237), Shancheng Ren (121352), Yinghao Sun (121372)   +4 more
core   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, Volume 13, Issue 57, 14 October 2026.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Loss of GSTP1 in ventral prostate cribiform PIN/CIS lesions.

, 2013
Representative H and E images of ventral prostates from A) Control B) PhIP and C) tomato + broccoli + PhIP rats. D–F, IHC for GSTP1. Note loss of GSTP1 staining in cribiform PIN/CIS lesions in PhIP-alone (E) and tomato + broccoli + PhIP-treated (F) rats.
Angelo M. De Marzo (217134), Karen S. Sfanos (490241), Chung-Tiang Liang (490242), William G. Nelson (27581), Cory Brayton (490243), Kirstie Canene-Adams (365217), Srinivasan Yegnasubramanian (27577)   +6 more
core   +1 more source

Glutathione S-transferase enzyme activity and protein expression in patients with recurrent tonsillitis and idiopathic tonsillar hypertrophy

Biomedical Papers, 2019
Objectives: The palatine tonsil is a significant part of the secondary immune system. Tonsillitis and idiopathic tonsillar hypertrophy (ITH) are the most common pathologies of this component.
Sedat Aydin, Mehmet Gokhan Demir, Serpil Oguztuzun, Murat Kilic, Can Yilmaz, Onur Dirican   +5 more
doaj   +1 more source

Lipid Metabolic Reprogramming and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights From Lipidomics

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) exhibits profound resistance to chemotherapy that cannot be fully explained by mutational drivers alone. This review examines how lipid metabolic reprogramming contributes to cytotoxic chemotherapy resistance in PDAC and evaluates whether lipidomics and flux‐resolved metabolic analyses can identify ...
Revathi Valliyodu, Diya Maria Siril, Harsha Sanil, Areej Nazarudeen, Aswathy Usha Vijayamoorthy, Mahesh Chandran Valiyavilakathuveedu Rajan, Sudhina Sufina, Chandana Yesudas, Abhirami Nalinakshan, Radhika Achuthan, Muthunayagam Vibin, Janeesh Plakkal Ayyappan   +11 more
wiley   +1 more source

RAF1 Promotes Gstt1‐Mediated Ferroptosis by Promoting KDM1A Recruitment to Facilitate Pilocarpine‐Induced Acute Seizure‐Associated Neuronal Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In the hippocampus of mice with pilocarpine‐induced acute seizures and in glutamate‐treated neuronal cell lines, the mRNA and protein levels of RAF1 were significantly increased. RAF1 interacts with the KDM1A and recruits it to the promoter of Gstt1, thereby inhibiting the transcription of Gstt1.
Tiantian Lu, Yonghong Feng, Xiuling Chen, Liyan Shen, Min Liu, Yanping Jia   +5 more
wiley   +1 more source