Results 51 to 60 of about 16,641 (168)
Inflammatory and Immunological Basis of Periodontal Diseases
Journal of Periodontal Research, EarlyView.The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima +3 more
wiley +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
GSTP1 polymorphisms in patients with and without ATDH.
, 2016 GSTP1 polymorphisms in patients with and without ATDH.
Shouquan Wu (2826521) +10 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray +16 more
wiley +1 more source
Mass for GSTP1-1 and C101S variant after reaction with human saliva.a.
, 2014 aGSTP1-1 and C101SGSTP1-1 were incubated with human saliva (30 min at 25°C) (mass data are reported on the left column). On the central column, the theoretical values for the reduced GSTP1-1 and C101SGSTP1-1 are also reported.Mass for GSTP1-1 and C101S ...
Giorgio Ricci (235478) +10 more
core +1 more source
Physiological and anatomical determinants of placental drug transfer
The Journal of Physiology, EarlyView.Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis +3 more
wiley +1 more source
Molecular basis of gene-environment interactions in the pathogenesis of asthma and COPD
, 2010 The origins of respiratory disease, such as asthma in childhood and COPD in later life are unclear. Maternal smoking during pregnancy and low birth weight is associated with increased risk of asthma, poor lung function in adults and COPD in old age ...
Rose-Zerilli, Matthew J J +1 more
core +1 more source
International Journal of General Medicine, 2020 Alemeh Pourkeramati,1 Ehsan Zare Mehrjardi,1 Masoud Dehghan Tezerjani,2 Seyed Morteza Seifati1 1Medical Biotechnology Research Center, Ashkezar Branch, Islamic Azad University, Ashkezar, Yazd, Iran; 2Abortion Research Centre, Yazd Reproductive Sciences ...
Pourkeramati A +3 more
doaj
The Journal of Physiology, EarlyView.Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor +4 more
wiley +1 more source
The GSTP1 105Val allele increases breast cancer risk and aggressiveness but enhances response to cyclophosphamide chemotherapy in North China. [PDF]
PLoS ONE, 2013 The glutathione-S-transferase (GST) family contributes to the inactivation of various toxic compounds formed as secondary metabolites during oxidative stress. GSTP1 accounts for the majority of the GST family enzymatic activity, and the activity of GSTP1
Jie Ge +7 more
doaj +1 more source