Results 11 to 20 of about 16,641 (168)

GSTP1 rs1138272 Polymorphism Affects Prostate Cancer Risk

Medicina, 2020
Background and Objectives: One of the most frequent genetic alterations reported to date in prostate cancer (PC) is aberrant methylation of glutathione transferase P1 (GSTP1).
Veljko Santric, Milica Djokic, Sonja Suvakov, Marija Pljesa-Ercegovac, Marina Nikitovic, Tanja Radic, Miodrag Acimovic, Vesna Stankovic, Uros Bumbasirevic, Bogomir Milojevic, Uros Babic, Zoran Dzamic, Tatjana Simic, Dejan Dragicevic, Ana Savic-Radojevic   +14 more
doaj   +3 more sources

Assessment of Glutathione-S-Transferase (GSTP1) methylation status is a reliable molecular biomarker for early diagnosis of prostatic intraepithelial neoplasia [PDF]

World Cancer Research Journal, 2019
OBJECTIVE: Prostate Specific Antigen (PSA) is a commonly used marker for the diagnosis and follow-up of Prostate Cancer (PC) and Prostatic Intraepithelial Neoplasia (PIN).
E. Varriale, A. Ferrante, F. Crocetto, M. Cianciulli, E. Palermo, A. Vitale, G. Benincasa   +6 more
doaj   +3 more sources

CLDN6 promotes chemoresistance through GSTP1 in human breast cancer

Journal of Experimental & Clinical Cancer Research, 2017
Background Claudin-6 (CLDN6), a member of CLDN family and a key component of tight junction, has been reported to function as a tumor suppressor in breast cancer. However, whether CLDN6 plays any role in breast cancer chemoresistance remains unclear.
Minlan Yang, Yanru Li, Xiangfeng Shen, Yang Ruan, Yan Lu, Xiangshu Jin, Peiye Song, Yantong Guo, Xiaoli Zhang, Huinan Qu, Yijia Shao, Chengshi Quan   +11 more
doaj   +2 more sources

Simultaneous identification of GSTP1 Ile105→Val105 and Ala114→Val114 substitutions using an amplification refractory mutation systempolymerase chain reactionassay: studies in patients with asthma [PDF]

Respiratory Research, 2001
Background The glutathione S-transferase (GST) enzyme GSTP1 utilizes byproducts of oxidative stress. We previously showed that alleles of GSTP1 that encode the Ile105→Val105 substitution are associated with the asthma phenotypes of atopy and bronchial ...
Strange Richard C, Hepple Michael, Fryer Anthony A, Hemmingsen Anja, Spiteri Monica A   +4 more
doaj   +2 more sources

Irreversible methadone-induced GSTP1 downregulation in SH-SY5Y cells

Egyptian Journal of Medical Human Genetics
Background Methadone has been reported to downregulate the expression of glutathione S-transferase P1 (GSTP1) among nine antioxidant genes in SH-SY5Y cells after both short- and long-term treatment.
Khyber Saify, Mostafa Saadat
doaj   +2 more sources

Co-localization of GSTP1 and JNK in transitional cell carcinoma of urinary bladder

Genetics and Molecular Biology, 2010
Transitional cell carcinoma (TCC) of urinary bladder belongs to glutathione S-transferase P1 (GSTP1) overexpressing tumors. Upregulated GSTP1 in TCC is related to apoptosis inhibition. This antiapoptotic effects of GSTP1 might be mediated through protein:
Marija Pljesa-Ercegovac, Ana Savic-Radojevic, Tamara Kravic-Stevovic, Vladimir Bumbasirevic, Jasmina Mimic-Oka, Tatiana Simic   +5 more
doaj   +1 more source

Involvement of GSTP1 in low dose radiation-induced apoptosis in GM12878 cells

Ecotoxicology and Environmental Safety
Background: Low-dose ionizing radiation-induced protection and damage are of great significance among radiation workers. We aimed to study the role of glutathione S-transferase Pi (GSTP1) in low-dose ionizing radiation damage and clarify the impact of ...
Jian Cui, Linwei Li, Shuang Wei, Yuanyun Wei, Yaqi Gong, Hongxia Yan, Yueqiu Yu, Xiang Lin, Hui Qin, Guoqing Li, Lan Yi   +10 more
doaj   +2 more sources

GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study

International Journal of COPD
Honge Li,1,* Raorao Wang,1,* Xueyan Wei,1,* Chunyan Zhang,1 Wenhui Pei,1 Xuhui Zhang,2 Zhen Yang,1 Zhi Li,3 Yuhuan Zhang,1 Yanli Shi,1 Yunchao Wang,4 Xinhua Wang1 1Institute of Public Health, Gansu University of Chinese Medicine, Lanzhou ...
Li H, Wang R, Wei X, Zhang C, Pei W, Zhang X, Yang Z, Li Z, Zhang Y, Shi Y, Wang Y, Wang X   +11 more
doaj   +1 more source

Methylation profiles of global LINE-1 DNA and the GSTP1 promoter region in children exposed to lead (Pb)

Epigenetics, 2022
Lead (Pb) exposure has adverse health effects and altered DNA methylation may contribute to Pb toxicity. LINE-1 is an interspersed repeated DNA that is used as a surrogate marker for estimating genomic DNA methylation levels, and GSTP1 is an isozyme that
Yared Beyene Yohannes, Shouta M.M. Nakayama, John Yabe, Haruya Toyomaki, Andrew Kataba, Hokuto Nakata, Kaampwe Muzandu, Chihiro Miyashita, Yoshinori Ikenaka, Kennedy Choongo, Mayumi Ishizuka   +10 more
doaj   +1 more source

Predicting the development and progression of primary open-angle glaucoma based on the determination of GST gene polymorphisms

Journal of Ophthalmology, 2018
Background: Epidemiological studies have demonstrated that primary open-angle glaucoma (POAG) is a complex multifactorial disease resulting from interaction of risk factors and gene polymorphisms.
S.O. Rykov, A.V. Burdei, S.V. Ziablitsev, S.Yu. Mogilevskyy   +3 more
doaj   +1 more source