Results 31 to 40 of about 5,937 (164)

Genetic polymorphism of carcinogen metabolic enzymes in oral submucous fibrosis

Journal of Indian Academy of Oral Medicine and Radiology, 2022
Background: Biotransformation plays a crucial role in carcinogen activity. Genetic polymorphisms in xenobiotic-metabolizing enzymes crucial to a carcinogen and drug metabolism lead to variations in their activity. These enzymes increase cancer risk by an
Sunu Ramachandran, Anita Balan, C Tinky Bose, Prabha Balaram, V Nityasri   +4 more
doaj   +1 more source

Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells

Particle and Fibre Toxicology, 2012
Background Diesel exhaust particles (DEP) contribute substantially to ambient particulate matter (PM) air pollution in urban areas. Inhalation of PM has been associated with increased incidence of lung disease in susceptible populations.
Wu Weidong, Peden David B, McConnell Rob, Fruin Scott, Diaz-Sanchez David   +4 more
doaj   +1 more source

GSTM1, GSTT1 and GSTP1 Polymorphisms in the Korean Population [PDF]

Journal of Korean Medical Science, 2005
The isoenzymes of the glutathione s transferase (GST) family play a vital role in phase II of biotransformation of many substances. Using a multiplex polymerase chain reaction and a direct sequencing analysis, the frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms were evaluated in 1,051 Korean male subjects.
Cho, Hyun-Jung, Lee, Soo-Youn, Ki, Chang-Seok, Kim, Jong-Won   +3 more
openaire   +2 more sources

Gstm1 Null Polymorphism and Palmar Dermatoglypics in Oral Leukoplakia

Indian Journal of Dental Research, 2021
Background: An individual's risk towards development of cancer depends not only on environmental factors or extrinsic exposure to carcinogens but also on individual's genetic susceptibility. Aim: To determine two genetically ...
Lakshanika Yogesh, Nalini Aswath
openaire   +3 more sources

Gene Expression and DNA Methylation Status of Glutathione S-Transferase Mu1 and Mu5 in Urothelial Carcinoma.

PLoS ONE, 2016
Bladder cancer is highly recurrent after therapy, which has an enormous impact on the health and financial condition of the patient. It is worth developing diagnostic tools for bladder cancer.
Shou-Chieh Wang, Chin-Chin Huang, Cheng-Huang Shen, Lei-Chen Lin, Pei-Wen Zhao, Shih-Ying Chen, Yu-Chiao Deng, Yi-Wen Liu   +7 more
doaj   +1 more source

The CYP1A1 and GSTM1 Genetic Polymorphisms and Susceptibility to Endometriosis in Women from South India [PDF]

International Journal of Fertility and Sterility, 2008
Background Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility.
Roya Rozati, Satyanarayana Reddy, Simha Baludu Giragalla, Hamid Bakshi, Srikanth Doddmaneni, Nasaruddin Khaja, Radhey Sham Sharma   +6 more
doaj   +1 more source

Glutathione S-transferase M1 and T1 polymorphisms and the risk of mild hepatotoxicity induced by carbamazepine in a tunisian population study

BMC Neurology, 2018
Background The aim of this study was to evaluate whether the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) null alleles may contribute to carbamazepine-induced hepatotoxicity.
Chahra Chbili, Anis Hassine, Neila Fathallah, Manel Nouira, Salma Naija, Sofiene Ben Ammou, Saad Saguem   +6 more
doaj   +1 more source

Role of Glutathione S-transferase (GSTM1, GSTT1) and CYP1A1 (cytochrome p450) Gene Polymorphisms in Susceptibility to Acute Myeloid Leukemia

Middle East Journal of Cancer, 2020
Background: Acute myeloid leukemia (AML) may originate from the combination of genetic susceptibility factors and environmental exposure. The aim of this study was to investigate the association of GSTM1 and GSTT1 null genotypes and CYP1A1*2A allele with
Yousef Mortazavi, Robab Rahimi, Fatemeh Azimi, Shahrbano Rostami, Minoosh Moghimi, Soghrat Faghihzadeh, Saeide Mazloomzadeh   +6 more
doaj   +1 more source

CYP1A1 and GSTM1 genes associated with the risk of developing colorectal cancer: a case-control study in the Lima region of Peru [PDF]

Pharmacia
The presence of CYP1A1 allelic variants and deletion of the glutathione S-transferase GSTM1 gene, and their imbalance, have been suggested as risk factors for inducing colorectal cancer (CRCa).
Angel T. Alvarado, María Saravia-Bartra, Robert Malpartida-Palomino, Cynthya Carolin Cárdenas-Guerrero, Jorge A. García, María R. Bendezú, Haydee Chávez, Doris Laos-Anchante, Juan J. Palomino-Jhong, Aura Molina-Cabrera, Pompeyo Cuba-Garcia, Elizabeth J. Melgar-Merino, Nelly Vega-Ramos, Felipe Surco-Laos, Paulina Eliades Yarasca-Carlos, Nelson Varela, Luis Abel Quiñones, Dante Daniel Cáceres-Lillo, Amparo Iris Zavaleta, Mario Pineda-Pérez   +19 more
doaj   +3 more sources

GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis

Genetics and Molecular Research, 2017
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist.
D A, Rodrigues, J V M, Martins, K S F, E Silva, I R, Costa, M H, Lagares, F L, Campedelli, A M, Barbosa, M P, de Morais, K K V O, Moura   +8 more
openaire   +2 more sources