Results 21 to 30 of about 5,937 (164)

Use of site-directed mutagenesis of allele-specific PCR primers to identify the GSTM1 A, GSTM1 B, GSTM1 A,B and GSTM1 null polymorphisms at the glutathione S-transferase, GSTM1 locus

, 1993
We describe the identification of the GSTM1 null, GSTM1 A, GSTM1 B and GSTM1 A,B polymorphisms at the glutathione S-transferase GSTM1 locus using a single-step PCR method.
Fryer, A A, Strange, R C, Alldersea, J, Zhao, L, Pearson, W R   +4 more
core   +5 more sources

Diet, GSTM1 and GSTT1 and head and neck cancer [PDF]

Carcinogenesis, 2003
A decreased incidence of squamous cell carcinoma of the head and neck (SCCHN) associated with fruit and vegetable intake may act through chemopreventive compounds, which may be more available to persons homozygous for the deletion genotypes of the glutathione S-transferase (GST).
M M, Gaudet, A F, Olshan, C, Poole, M C, Weissler, M, Watson, D A, Bell   +5 more
openaire   +2 more sources

GSTM1 Modulates Expression of Endothelial Adhesion Molecules in Uremic Milieu [PDF]

, 2021
Deletion polymorphism of glutathione S-transferase M1 (GSTM1), a phase II detoxification and antioxidant enzyme, increases susceptibility to end-stage renal disease (ESRD) as well as the development of cardiovascular diseases (CVD) among ESRD patients ...
Suvakov, Sonja, Simic, Tatjana, Jerotic, D, Matic, M, Savic-Radojevic, A, Damjanovic, T, Savic-Radojevic, Ana, Simic, T, Matic, Marija, Alqudah, Abdelrahim, Dimkovic, Nada, Grieve, David J.; id_orcid, Pljesa-Ercegovac, Marija, Dimkovic, N, Damjanovic, Tatjana, Jerotic, Djurdja, Grieve, DJ, Pljesa-Ercegovac, M, Suvakov, S, Alqudah, A, McClements, L, McClements, Lana   +21 more
core   +1 more source

Genetic polymorphisms of GSTM1 and GPX1 genes and smoking susceptibility in the Saudi population

Journal of Pharmacy and Bioallied Sciences, 2023
Background/Objective/Methods: Glutathione-S-transferase Mu1 (GSTM1) and glutathione peroxidase 1 (GPX1) are known antioxidant enzymes that help protect cells from the oxidative damage that occurs from smoking.
Maryam Hassan Al-Zahrani, Nawal Marzoog Almutairi   +1 more
doaj   +1 more source

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
Ma, Jinfeng, Xuemei Yao, Mingqin Cao, Merle Corinne, Xia Zhu, Liu Wei, Weidong Wu, Yongguang Li, Jiayi Gu, Ma Jinfeng, Qian Wang, Milligan Paul, Zhu, Xia, Ying Mao, Liu, Wei, Ma Long, Jinfeng Ma, Xiang, Yang, Cao, Mingqin, Ma, Long, Merle, Corinne, Long Ma, Yang Lei, Xiang Yang, Yao Xuemei, Wubuli, Atikaimu, Wu, Weidong, Xin Xiumei, Li, Yongguang, Yang Xiang, Paul Milligan, Xiumei Xin, Lei Yang, Corinne Merle, Zhu Xia, Li Yongguang, Mao Ying, Milligan, Paul, Mao, Ying, Gu, Jiayi, Atikaimu Wubuli, Gu Jiayi, Yao, Xuemei, Wu Weidong, Wang Qian, Yang, Lei, Xin, Xiumei, Wang, Qian, Cao Mingqin, Wubuli Atikaimu, Wei Liu   +50 more
core   +1 more source

Cytogenetic effects of tick-borne encephalitis in residents of the north of Western Siberia with alimentary-constitutional obesity depending on the polymorphism of the genes of glutathione-S-transferase

Ожирение и метаболизм, 2017
Backgraund. Tick-borne encephalitis (TBE), one of the large-scale public health problems of the Siberian region, can cause significant cytogenetic damage in humans by stimulating oxidative stress. Active functioning of the detoxification system including
Ekaterina N. Ilyinskikh, Nicolai Nicolaevich Ilyinskikh   +1 more
doaj   +1 more source

Glutathione S-transferase (GSTT1 and GSTP1) Polymorphisms Improves the Short- and Long-Term Efficacy of Concurrent Chemoradiotherapy in Advanced Ovarian Cancer [PDF]

Molecular Biology & Nanomedicine, 2020
Over the past four decades, patients with advanced ovarian cancer (OC) has enjoyed greatly improved survival rate considering advances in combined chemotherapy with platinum and paclitaxel.
Xiao Xu, Zhuo Zhong, Dong-Mei Dou, Fenfen Li   +3 more
doaj   +1 more source

Lung Cancer and CYP1A1 or GSTM1 Polymorphisms

Environmental Health and Preventive Medicine, 2003
Most chemical carcinogens are metabolized and activated in vivo by phase I enzymes including the microsomal cytochromes P450 and epoxide hydroxylases. The carcinogens and their metabolites are detoxified by phase II enzymes that include various transferases such as glutathion-S-transferases (GST).
OYAMA, Tsunehiro, KAGAWA, Norio, KIM, Yong-Dae, MATSUMOTO, Akiko, ISSE, Toyohi, KAWAMOTO, Toshihiro   +5 more
openaire   +1 more source

Glutathione S-Transferase M1/T1 Polymorphisms and Schizophrenia Risk: A New Method for Quality Assessment and a Systematic Review

Neuropsychiatric Disease and Treatment, 2023
Hongzhou Liu,* Ying Xu,* Jie Peng School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jie Peng, Email ...
Liu H, Xu Y, Peng J
doaj  

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population [PDF]

Pharmacia, 2021
The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele ...
Angel Tito Alvarado, Ana María Muñoz, María Saravia Bartra, Milton Valderrama-Wong, Daniela González, Luis Abel Quiñones, Nelson Varela, María Rocío Bendezú, Jorge Antonio García, Berta Loja-Herrera   +9 more
doaj   +3 more sources