Results 41 to 50 of about 5,937 (164)

Polymorphisms of GSTM1, GSTT1, and p53 in Goiânia, Goiás

Genetics and Molecular Research, 2015
Genetic polymorphisms are defined as changes within the DNA sequences of genes that have frequencies in the population higher than 1%. The glutathione S-transferases play an important role in the cellular detoxification systems involved in oxidative stress that can lead to accumulation of reactive oxygen species.
D A, Rodrigues, I R, Costa, J V M, Martins, K S F, E Silva, K K V O, Moura   +4 more
openaire   +2 more sources

Polymorphisms of CYP1A1 I462V and GSTM1 genotypes and lung cancer susceptibility in Mongolian [PDF]

, 2009
Aim: To study the genotype of cytochrome P450 1A1(CYP1A1) I462V and glutathions S-transferase M1( GSTM1) and the relationship of the genetic polymorphism of them with the susceptibility of lung cancer in Mongolia of China.
Guang Wang, Zhi-Xie Zhang, Qin Yin, Jia Ma, Fuhou Chang, Min-jie Wang, Jun QI   +6 more
core  

Association between copy number of the GSTM1 and GSTT1 genes and risk of prostate cancer.

, 2014
aUnconditional logistic regression adjusted for age and education for GSTM1; for age and family history of prostate cancer for GSTT1; for age and PSA screening history for the sum of GSTM1 and GSTT1 alleles.bGSTM10 and GSTT10;cGSTM10 and GSTT11 or GSTM11
Luc Multigner (421573), Marc Romana (287952), Cédric Broquère (626905), Séverine Ferdinand (62784), Pascal Blanchet (421572), Laurent Brureau (626906), Elise Emeville (421568)   +6 more
core   +1 more source

Association between GSTM1 and GSTT1 allelic variants and head and neck squamous cell cancinoma.

PLoS ONE, 2012
BackgroundsGSTM1 and GSTT1 are involved in the detoxification of carcinogens such as smoking by-products, and polymorphisms in these two genes with a result of loss of enzyme activity may increase risk of carcinogenesis.
Yang Zhang, Yuanyuan Ni, Hao Zhang, Yongchu Pan, Junqing Ma, Lin Wang   +5 more
doaj   +1 more source

Distribution of polymorphic genotypes of GSTP1, GSTM1 and GSTT1 and their association with primary open-angle glaucoma

Journal of Ophthalmology, 2018
Background: The role of genetic factors in the development of primary open-angle glaucoma (POAG) has been confirmed previously. Activation of oxidative stress with a reduction in the activity of glutathione S transferase (GST) family enzymes is a major ...
S.O. Rykov, A.V. Burdei, S.V. Ziablitsev, S.Iu. Mogilevskyy   +3 more
doaj   +1 more source

Effect of Glutathione S‐Transferase and Metallothionein Polymorphisms on Mercury Levels and End‐Stage Renal Disease (ESRD) in Colombian Patients

Environmental Toxicology, EarlyView.
ABSTRACT Epidemiological studies have demonstrated a link between chronic kidney disease (CKD) and environmental mercury (Hg) exposure. Colombia has a well‐documented history of artisanal and small‐scale gold mining, where Hg exposure affects miners and nearby riverside and urban populations. This study aimed to evaluate the effects of polymorphisms in
Diana M. Narváez, Juliana Lago, Carlos Trillos, Marcela Varona, Leonardo Briceño, Ruth Marien Palma, Sonia M. Díaz, Gilma Hernández, Eliana M. Téllez, Juan Sebastián Aguilar, Daniela Castellanos, Xavier Martínez, Estefanía Zapata, Alix Rocio Barrios, Ignacio Villanueva, Michael R. Fonseca, Helena Groot   +16 more
wiley   +1 more source

Energetic dysregulations in psychotic disorders: Targets for new therapeutics

The FEBS Journal, EarlyView.
The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson, Kai‐Christian Sonntag, Thao Do Vy Le, Kaitlin Shannon, Chao Wang, Fei Du, Xi Chen, Donna McPhie, Dost Ongur, Bruce Cohen, Virginie‐Anne Chouinard   +10 more
wiley   +1 more source

Mitochondrial Ca2+ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodelling in the mouse brain

The Journal of Physiology, EarlyView.
Abstract figure legend The genetic inactivation of one Mcu allele leads to sex‐specific changes in neuronal function in adult mice, that is, the firing of action potentials and the relationship between cytosolic and mitochondrial Ca2+ levels. The ability to produce NAD(P)H by stimulated neural tissue is largely preserved in male mice but delayed in ...
Jenna Gray, Girish Halemirle, Beatriz Ferrán, Hadyn Rose, Traci L. Redwine, Sophia Pham, Bo Hagy, Atul Pranay, Jennifer Giorgione, Stacy A. Hussong, Veronica Galvan, Kenneth Humphries, Holly Van Remmen, Mike Kinter, William E. Sonntag, Pankaj K. Singh, Carlos Manlio Díaz‐García   +16 more
wiley   +1 more source

Summary of meta-analysis of GSTM1, GSTT1 and GSTP1 polymorphisms and PCa risk.

, 2012
OR, odds ratio; CI, confidence interval.*GSTP1 the total result of after excluding three researches deviated from Hardy-Weinberg equilibrium (HWE).aGSTM1 (−/−) and GSTT1 (−/−) vs.
Mancheng Gong (117913), Wenjing Dong (117921), Ruihua An (117936), Yangyang Xu (117932), Zhirong Shi (117928), Wenjun Ni (117934)   +5 more
core   +1 more source

Monitoring of cytogenetic effects in tick-borne encephalitis patients with type 2 diabetes mellitus, depending on polymorphism of glutathione-S-transferase genes

Сахарный диабет, 2019
BACKGROUND: Tick-borne encephalitis (TBE) is an acute viral disease with activation of oxidative stress and increasing in cytogenetic instability. Clinical symptoms of infectious diseases usually more severe in patients with type 2 diabetes mellitus (DM2)
Nikolay N. Ilyinskikh, Marina S. Kostromeeva, Ekaterina N. Ilyinskikh   +2 more
doaj   +1 more source