Results 51 to 60 of about 5,937 (164)

Detection of glutathione S-transferases M1, T1 gene deletions among cancer patients in Mongolia

Proceedings of the Mongolian Academy of Sciences, 2020
Various types of toxic xenobiotic and electrophilic compounds, which were formed from the glutathione S-transferases cell metabolism and the oxidation stress, are the group enzymes with detoxification roles that are involved in the metabolism phase II ...
Temuujin Janchiv, Enkhgerel Dorj, Ochirkhuyag Baldorj, Khulan Janchiv   +3 more
doaj   +1 more source

A study of the association of glutathione S-transferase M1/T1 polymorphisms with susceptibility to vitiligo in Egyptian patients [PDF]

Anais Brasileiros de Dermatologia, 2018
: Background: The association of glutathione S-transferases M1/T1 (GSTM1/T1) null polymorphisms with vitiligo was proposed in several studies including two Egyptian studies with contradictory results.
Dalia Gamal Aly, Samar Abdallah Salem, Khalda Sayed Amr, Mahmoud Fawzy Abd El-Hamid   +3 more
doaj   +2 more sources

The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Among Children Exposed to Environmental Mutagens: A Systematic Review

Journal of Applied Toxicology, Volume 46, Issue 12, Page 4396-4408, December 2026.
ABSTRACT Children, as a particularly vulnerable group, are more susceptible to these mutagens due to their developing immune systems, higher physiological vulnerability, and increased exposure through behaviors like outdoor play and hand‐to‐mouth activities. This review aims to investigate the relationship between these environmental exposures, genetic
Thiago Guedes Pinto, Daniel Vitor de Souza, Gabriel Carvalhal de Aguiar, Ana Claudia Muniz Renno, Patricia Ramos Cury, Jean Nunes dos Santos, Rogerio Aparecido Dedivitis, Daniel Araki Ribeiro   +7 more
wiley   +1 more source

Polymorphisms of the GSTT1 and GSTM1 genes in polycystic ovary syndrome [PDF]

Revista da Associação Médica Brasileira, 2020
SUMMARY BACKGROUND: This study aimed to investigate the deletion polymorphisms of the genes of the glutathione S-transferase family GSTT1 and GSTM1 in patients with Polycystic Ovarian Syndrome (PCOS), comparing them with a control population. METHODS: Blood was collected from 219 women (110 with PCOS and 109 controls) and genomic DNA was extracted ...
Mariana Mendes Porto Azevedo, Alessandra Bernadete Trovó de Marqui, Bruna Tavares Bacalá, Marly Aparecida Spadotto Balarin, Elisabete Aparecida Mantovanni Rodrigues de Resende, Marco Fábio Prata Lima, Mariana Kefalás de Oliveira Gomes, Mariangela Torreglosa Ruiz Cintra   +7 more
openaire   +4 more sources

Pharmacogenomics in Cancer Treatment: Challenges and Opportunities in African Settings

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Cancer incidence in Africa is projected to reach 2.1 million new cases annually by 2040. Current treatment guidelines remain largely based on pharmacogenomic data predominantly from European and Asian genetic profiles, potentially compromising safety and efficacy in African patients.
Ntombikhona Fortunate Maphumulo, George Rebello, Veron Ramsuran   +2 more
wiley   +1 more source

GSTM1, smoking and lung cancer: a case-control study [PDF]

International Journal of Epidemiology, 1999
We conducted a case-control study to examine the risk of lung cancer in relation to GSTM1 polymorphism and cigarette smoking (primarily of black tobacco) in a French population.The 611 subjects were 301 incident lung cancer cases and 310 hospital controls. We were able to constitute a DNA bank for 547 subjects (89.5%) and gather detailed information on
I, Stücker, I, de Waziers, S, Cenée, J, Bignon, A, Depierre, B, Milleron, P, Beaune, D, Hémon   +7 more
openaire   +2 more sources

Nulidade de GSTT1/GSTM1 relacionada a pesticidas associa-se com doenca de Parkinson [PDF]

, 2013
Genetic and environmental factors affect the pathogenesis of Parkinson's disease(PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be relatedto the disease.
Gregorio, Michele Lima, Camila Montoro Mazeti, Martins, Denise Poltronieri, Denise Poltronieri Martins, Tognola, Waldir Antonio, Souza, Dorotéia Rossi Silva, Florim, Greiciane Maria da Silva, Oliveira, Fabio de Nazare, Doroteia Rossi Silva Souza, Caroline Leiko Sado, Marcelo Arruda Nakazone, Longo, Gabriela dos Santos, Gisele Sousa Amorim, Fabio de Nazare Oliveira, Nakazone, Marcelo Arruda, Marcela Augusta de Souza Pinhel, Amorim, Gisele Sousa, Gabriela dos Santos Longo, Mazeti, Camila Montoro, Michele Lima Gregorio, Greiciane Maria da Silva Florim, Waldir Antonio Tognola, Sado, Caroline Leiko [UNIFESP], Pinhel, Marcela Augusta de Souza   +23 more
core   +1 more source

CYP1A1, CYP2E1 and GSTM1 genetic polymorphisms. The effect of single and combined genotypes on lung cancer susceptibility in Chilean people [PDF]

, 2001
Artículo de publicación ISICYP1A1, CYP2E1 and GSTM1 polymorphisms were evaluated in Chilean healthy controls and lung cancer patients. In the Chilean healthy group, frequencies of CYP1A1 variant alleles for MspI (m2 or CYP1A1*2A) and ile/val (val or ...
F Berthou, A.M Aguilera, K Lee, L Gil, Godoy, J., Berthou, F., D Cáceres, Quiñones Sepúlveda, Luis, Cáceres Lillo, Dante, Acevedo, C., Gil, Lionel, Varela Figueroa, Nelson, Martínez, L., J Godoy, Lee, K., L Quiñones, N Varela, L Martı́nez, Aguilera, A. M., Lucas, D., D Lucas, C Acevedo   +21 more
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1338-1347, November 2026.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

A Nelore Cattle Structural Variant Catalog

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Structural variants (SVs) contribute more nucleotide divergence between mammalian genomes than single nucleotide polymorphisms, yet no population‐scale, long‐read‐validated SV catalog has been available for Bos indicus cattle. Nelore, the most numerically important indicine breed worldwide, diverges substantially from the taurine‐derived ...
Thales de Lima Silva, Alexander S. Leonard, Pablo Augusto de Souza Fonseca, Haroldo Henrique de R. Neves, Alexandre M. Ruiz, Lucas Tassoni Andrietta, Gerardo A. Fernandes Júnior, Júlio Cesar de C. Balieiro, Hubert Pausch, Roberto Carvalheiro, Ricardo Vieira Ventura   +10 more
wiley   +1 more source