Results 71 to 80 of about 5,937 (164)

Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member,GSTM2 [PDF]

, 2013
The gene for glutathione-S-transferase (GST) M1 (GSTM1), a member of the GST-superfamily, is widely studied in cancer risk with regard to the homozygous deletion of the gene (GSTM1 null), leading to a lack of corresponding enzymatic activity.
Paul, Somnath, Bandyopadhyay, Arun, Giri, Ashok K, Bhattacharjee, Pritha, Banerjee, Priyam, Patra, Deblina, Banerjee, Mayukh, Ghoshal, Nanda   +7 more
core   +1 more source

Relevance of Polymorphism of Glutathione S-Transferase Genes (GSTM1 and GSTT1) in Diabetic Retinopathy and Diabetic Nephropathy

Indian Journal of Endocrinology and Metabolism
Introduction: The causative factors of diabetic retinopathy and nephropathy are genetic as well as environmental. The Glutathione S-transferase gene family is involved in redox balance to reduce oxidative stress, which is an important factor associated ...
Vaishali S. Pawar, Kailas D. Datkhile, Ajit V. Sontakke, Satyajeet K. Pawar, Prajakta S. Patil   +4 more
doaj   +1 more source

Mucoadhesive Peptide‐Catalase Self‐Assembled Nano‐Formulation for Effective Treatment of Mucosal Inflammatory Diseases

Advanced Science, Volume 13, Issue 54, 28 September 2026.
CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li, Yuxuan Ma, Di He, Yingying Huang, Yutong Jiang, He Zhao, Shengjie Ge, Ruirui Zhao, Hejia Yuan, Wendi Jiang, Wenjun Zhu, Kai Liu, Han Zhang, Zhuang Liu   +13 more
wiley   +1 more source

Detection of GSTM1-null Genotype in Women Undergoing IVF Treatment

, 2023
Background: Glutathione S-transferase (GST) M1 belongs to a family of detoxification enzymes and deficiency in enzyme activity is due to a homozygous deletion of the GSTM1 gene. Several studies reveal a possible correlation between female infertility and
Anastasios Potiris, Peter Drakakis, Ioannis Chrysanthopoulos, Christos Koratzanis, Sofoklis Stavros, Eirini Drakaki, Paraskevas Perros, Dionysios Vrachnis, Pavlos Machairoudias, Theodoros Karampitsakos, Nikolaos Machairiotis, Despoina Mavrogianni, Angelos Petsavas   +12 more
core   +2 more sources

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, Volume 92, Issue 9, Page 3257-3264, September 2026.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

GSTM1 polymorphism in patients with primary open-angle glaucoma

Genetics and Molecular Research, 2012
Primary open-angle glaucoma (POAG) is characterized by loss of retinal ganglion cells, optic nerve damage and irreversible loss of visual field. Glaucoma is the second leading cause of blindness worldwide. It was estimated that in 2010 there were about 60.5 million glaucoma cases worldwide; among these patients, 4.5 million will become bilaterally
A M, Barbosa, A B, Frare, N B, Costa, R E, Silva, K K V O, Moura   +4 more
openaire   +2 more sources

Individual sensitivity to cytogenetic effects of benzo[alpha]pyrene in cultured human lymphocytes: influence of glutathione S-transferase M1 genotype

Genetics and Molecular Biology, 2006
Sister chromatid exchange (SCE) and chromosome aberrations (CA) in peripheral lymphocytes has been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genotoxins is benzo[alpha]pyrene (BaP).
Gülgün S. Güven, Mehmet Güven, Ilhan Onaran, Turgut Ulutin, Seniha Hacihanefioglu   +4 more
doaj   +1 more source

Alpha‐Synuclein Promotes Anterograde Vesicle Transport in Melanocytes and Melanoma Cells: A Pro‐Survival Function

Journal of the Chinese Chemical Society, Volume 73, Issue 9, Page 1218-1229, September 2026.
Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley   +1 more source

Meta-analysis of associations between GSTM1, GSTT1, and GSTM1-GSTT1 polymorphisms and endometriosis.

, 2014
Abbreviations: OR, odds ratio; CI, confidence interval; BS, based on score (studies with quality scores
Hong Shen (166278), Haili Zhu (627931), Shuguang Liu (87095), Jiming Bao (627932), Qing Chen (131379)   +4 more
core   +1 more source

Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta‐Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence

MedComm, Volume 7, Issue 9, September 2026.
Based on meta‐analyses and cumulative epidemiological evidence, the present study identifies 11 genetic variants in 11 genes that are truly associated with the risk of hepatocellular carcinoma. Our work presents a systematic synopsis, which helps elucidate the mechanisms of carcinogenesis and provides insights into the early diagnosis and novel ...
Yujin Shi, Bin Huang, Xiaohong Liu, Yalan Liu, Qinyong Hu, Tianyu Lei, Luqi Tang, Guanglin Xiao, Tingting Ning, Shengqin Yue, Jiahui He, Qilian Du, Xuanmei Li, Yixuan Zhou, Qiongfang Zhang, Chunyan Qi, Hong Ren, Hong‐Gang Ren   +17 more
wiley   +1 more source