Unveiling the Role of Vitamin D/VDR in Promoting Endometrial Decidualization [PDF]
International Journal of EndocrinologyVitamin D’s impact on reproductive health, particularly endometrial receptivity, has attracted significant attention. This study investigated the effects of vitamin D and its receptor (VDR) on decidualization in human endometrial stromal cells (HESCs ...
Jing Guo +4 more
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Identification, Expression and Evolutional Analysis of Two cyp19-like Genes in Amphioxus [PDF]
AnimalsThe mechanism of sex determination and differentiation in animals remains a central focus of reproductive and developmental biology research, and the regulation of sex differentiation in amphioxus remains poorly understood.
Yajun Wang +4 more
doaj +3 more sources
Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSAmT/mG Transgenic Mice
Cells, 2023 The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been extensively used for placenta-specific gene inactivation. In a pilot study, we observed unexpected phenotypes using this mouse strain, which prompted an extensive characterization ...
Prashanth Anamthathmakula +7 more
doaj +2 more sources
Potential of Indole-3-Carbinol compounds from broccoli (Brassica oleracea var. italica) as natural aromatase blockers: In silico prediction and in vivo studies [PDF]
Open Veterinary JournalBackground: Testosterone is a vital androgen hormone responsible for sex differentiation, producing male sex characteristics, spermatogenesis, and fertility. Abnormalities in testosterone levels, leading to reduced weight gain and reproductive capacity,
Reski Amalia +6 more
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Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women [PDF]
BMC Medical GenomicsPurpose The objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene and the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women.
Ya-li Hao +6 more
doaj +2 more sources
Breast Cancer Cytochromes P450: Chemopreventive and/or Therapeutic Targets for Naturally Occurring Phytochemicals [PDF]
MoleculesEstrogens are considered the most important risk factor for the development of breast cancer. Therefore, attempts are being made to reduce their level through diminished synthesis on one hand and to protect against the formation of DNA-damaging estrogen ...
Hanna Szaefer +3 more
doaj +2 more sources
Acephate Exposure Induces Transgenerational Ovarian Developmental Toxicity by Altering the Expression of Follicular Growth Markers in Female Rats [PDF]
BiologyAcephate is an organophosphate foliar and soil insecticide that is used worldwide. In this study, the transgenerational ovarian developmental toxicity caused by acephate, along with its in utero reprogramming mechanisms, were explored.
Abeer Alhazmi +3 more
doaj +2 more sources
Biochemistry and Biophysics Reports, 2021 Human CYP19 spans a region of chromosome 15 of approximately 130 kb and encodes aromatase, an enzyme required for estrogen synthesis. In the human granulosa cell-line KGN, there are seven open chromatin regions within the CYP19 locus.
Naoe Kotomura +3 more
doaj +1 more source
Obgynia, 2023 Objective: We aim to assess the correlation between the CYP19 level, the visual analogue scale (VAS) pain and endometriosis American Society for Reproductive Medicine (ASRM) grading scale.
Fatimah Usman +3 more
doaj +1 more source
Orexin Decreases Aromatase Gene Expression in The Hypothalamus of Androgenized Female Rats [PDF]
International Journal of Fertility and Sterility, 2016 Background Orexin is a hypothalamic orexigenic neuropeptide, which third cerebral injection of it mainly exerts inhibitory effects on reproductive functions.
Maliheh Salimi +3 more
doaj +1 more source