Results 21 to 30 of about 13,126 (201)

Polymorphism C242T in the Cyp19 gene in meat sheep [PDF]

Brazilian Journal of Biology, 2016
Abstract The objective of this study was to evaluate the frequency of C242T polymorphism on the aromatase gene and the allelic and genotypic frequency of these variants in sheep belonging to four breed groups. Blood samples were collected from 187 animals of four breed groups: Dorper, Santa Inês, Texel and White Dorper, originated from herds in the ...
Mora, N. H. A. P., Silva, S. C. C., Tanamati, F., Schuroff, G. P., Macedo, F. A. F., Gasparino, E.   +5 more
openaire   +5 more sources

CYP19 haplotypes increase risk for Alzheimer’s disease [PDF]

Journal of Medical Genetics, 2006
Cytochrome P450 aromatase, an enzyme that catalyses the conversion of androgens to oestrogen, is expressed at high levels in the gonads and in the brain. Aromatase activity is increased in the nucleus basalis of Meynert during aging and in Alzheimer’s disease (AD), making the gene (CYP19), at 15q21.1, a potential candidate risk factor.We examined 18 ...
R, Huang, S E, Poduslo
openaire   +2 more sources

Association of CYP19 and ESR1 Pleiotropic Genes With Human Longevity [PDF]

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2010
Aromatase (CYP19) and estrogen receptor-alpha (ESR1) are involved in the metabolism of estrogens, which have a relevant role in female and male aging. Moreover, due to their influence on fertility, both genes may be part of the longevity-fertility trade-off mechanism.
CORBO, Rosa Maria, ULIZZI, Laura, L. Positano, R. Scacchi   +3 more
openaire   +7 more sources

The CYP19 RS4646 polymorphism IS related to the prognosis of stage I-II and operable stage III breast cancer. [PDF]

PLoS ONE, 2015
Aromatase, encoded by the CYP19 gene, catalyzes the final step of the conversion of androgens to estrogens. Given the critical role of CYP19 in estrogen synthesis, the potential influence of CYP19 rs4646 polymorphism on breast cancer survival, deserves ...
Xiying Shao, Yong Guo, Xiaohong Xu, Yabing Zheng, Jiwen Wang, Zhanhong Chen, Jian Huang, Ping Huang, Jufen Cai, Xiaojia Wang   +9 more
doaj   +1 more source

Effect of shell as natural testosterone boosters in Sprague Dawley rats [PDF]

Veterinary World, 2019
Aim: This study aimed to evaluate the effect of shell supplementation on the regulation of male reproduction in rats. Materials and Methods: The zinc (Zn) level of shell from blood clam (Anadara granosa), green mussel (Perna viridis), and conch shell (
Pudji Astuti, Claude Mona Airin, Sarmin Sarmin, Alfarisa Nururrozi, Sri Harimurti   +4 more
doaj   +1 more source

Molecular characterization and association studies of CYP19 (aromatase) allelic variants with reproduction and production traits in Sahiwal and Hariana cattle

Indian Journal of Animal Sciences, 2022
Anestrus is a major reproductive problem in bovines which occurs due to less secretion of estrogen from the ovarian follicles. Enzyme cytochrome P450 aromatase which helps in estrogen biosynthesis is encoded by CYP19 gene.
VISHAKHA UTTAM, MADHU TIWARI, SATYENDRA PAL SINGH, DEEPAK SHARMA, AVNEESH KUMAR, ADITYA KUMAR   +5 more
doaj   +1 more source

Estrone-α-2-Deoxy-Glucoside as a Targeted Therapy for Triple-Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity. [PDF]

Chem Biol Drug Des
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Huang TY, Wang MR, Chou FP, Huang SC, Hsiao PY, Wu TK.   +5 more
europepmc   +2 more sources

A Comprehensive Examination of CYP19 Variation and Breast Density [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2007
Mammographic density is one of the strongest risk factors for breast cancer. Numerous lines of evidence suggest that mammographic density is influenced by estrogen exposures ([1][1]-[5][2]). CYP19 produces aromatase, the enzyme responsible for conversion of androgens to estrogens in all tissues,
Janet E, Olson, Cynthia X, Ma, Linda L, Pelleymounter, Daniel J, Schaid, V Shane, Pankratz, Robert A, Vierkant, Zachary S, Fredericksen, James N, Ingle, Yanhong, Wu, Fergus, Couch, Thomas A, Sellers, Richard M, Weinshilboum, Celine M, Vachon   +12 more
openaire   +2 more sources

Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells [PDF]

, 2011
Androgens are crucial for normal folliculogenesis and female fertility as evidenced in androgen receptor-null and granulosa cell conditional knockout mice.
Carlos Stocco (7944737), Yan-Guang Wu (361812), Jill Bennett (7944728), Deepika Talla (7944863)   +3 more
core   +4 more sources

The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. [PDF]

PLoS ONE, 2015
The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine ...
Naoe Kotomura, Nobuhiro Harada, Satoru Ishihara   +2 more
doaj   +1 more source