Association between CYP19 gene SNP rs2414096 Polymorphism and polycystic ovary syndrome in Chinese women [PDF]
BMC Medical Genetics, 2009 Background Several studies have reported the association of the SNP rs2414096 in the CYP19 gene with hyperandrogenism, which is one of the clinical manifestations of polycystic ovary syndrome (PCOS).
Yi Long +10 more
doaj +5 more sources
Chrysoeriol Prevents TNFα-Induced CYP19 Gene Expression via EGR-1 Downregulation in MCF7 Breast Cancer Cells [PDF]
International Journal of Molecular Sciences, 2020 Estrogen overproduction is closely associated with the development of estrogen receptor-positive breast cancer. Aromatase, encoded by the cytochrome P450 19 (CYP19) gene, regulates estrogen biosynthesis.
Soon Young Shin +2 more
exaly +3 more sources
Impact of rs2414096 polymorphism of CYP19 gene on susceptibility of polycystic ovary syndrome and hyperandrogenism in Kashmiri women [PDF]
Scientific Reports, 2021 Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder in pre-menopausal women having complex pathophysiology. Several candidate genes have been shown to have association with PCOS.
Sairish Ashraf +5 more
doaj +2 more sources
Delineating the role of single-nucleotide polymorphism of CYP19 gene on aromatase activity in South Indian women with polycystic ovary syndrome [PDF]
Journal of Genetic Engineering and Biotechnology, 2023 Background Polycystic ovary syndrome is a common multifactorial endocrinopathy disorder affecting 5–15% of reproductive women worldwide. The CYP19 gene encodes key enzyme aromatase involved in androgen-to-estrogen conversion which plays a crucial role in
Pravesh Hegde +5 more
doaj +2 more sources
CYP19 gene variant confers susceptibility to endometriosis-associated infertility in Chinese women [PDF]
Experimental and Molecular Medicine, 2014 An aromatase encoded by the CYP19 gene catalyzes the final step in the biosynthesis of estrogens, which is related to endometriosis development. To assess the association of CYP19 gene polymorphisms with the risks of endometriosis, chocolate cysts and endometriosis-related infertility, a case-control study was conducted in Chinese Han women by ...
Jieqiang Lv
exaly +5 more sources
The Proportion of Chromatin Graded between Closed and Open States Determines the Level of Transcripts Derived from Distinct Promoters in the CYP19 Gene. [PDF]
PLoS ONE, 2015 The human CYP19 gene encodes aromatase, which converts androgens to estrogens. CYP19 mRNA variants are transcribed mainly from three promoters. Quantitative RT-PCR was used to measure the relative amounts of each of the three transcripts and determine ...
Naoe Kotomura +2 more
doaj +2 more sources
Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women [PDF]
BMC Medical GenomicsPurpose The objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene and the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women.
Ya-li Hao +6 more
doaj +2 more sources
Letrozole and Crocin: Protecting Leydig Cells and Modulating Androgen Receptor and CYP19 Gene Expression in Busulfan-Induced Azoospermia [PDF]
AnimalsThis study aimed to investigate the impact of letrozole and crocin on Leydig cells on busulfan-induced azoospermia using a rat model. A sample population consisting of thirty male rats was randomly assigned to five groups: (1) the control group, (2 ...
Shahrzad Nokhbeh Zaeem +3 more
doaj +2 more sources
Acephate Exposure Induces Transgenerational Ovarian Developmental Toxicity by Altering the Expression of Follicular Growth Markers in Female Rats [PDF]
BiologyAcephate is an organophosphate foliar and soil insecticide that is used worldwide. In this study, the transgenerational ovarian developmental toxicity caused by acephate, along with its in utero reprogramming mechanisms, were explored.
Abeer Alhazmi +3 more
doaj +2 more sources
Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer [PDF]
Lung Cancer, 2011 Takeshi Ishizaki +2 more
exaly +2 more sources