Results 41 to 50 of about 2,702,703 (186)

The CYP19 Gene and Associations with Androgens and Abdominal Obesity in Premenopausal Women [PDF]

Obesity Research, 2003
AbstractObjective: Elevated androgens in women are associated with type 2 diabetes and are dependent on the conversion to estrogens by aromatase cytochrome P450. Polymorphisms of a tetranucleotide repeat [TTTA]n in the fourth intron of the CYP19 gene are associated with endocrine‐dependent diseases and were examined in relation to hormone levels and ...
Fariba, Baghaei, Roland, Rosmond, Lars, Westberg, Monica, Hellstrand, Elias, Eriksson, Göran, Holm, Per, Björntorp   +6 more
openaire   +2 more sources

Associations between aromatase CYP19 rs10046 polymorphism and breast cancer risk: from a case-control to a meta-analysis of 20,098 subjects. [PDF]

PLoS ONE, 2013
Lifetime exposure to estrogen is a factor that plays an important role in the pathogenesis and progression of breast cancer. Genetic variants in genes of the biosynthesis and metabolism of estrogen have been associated with breast cancer risk. Among them,
Begoña Pineda, Miguel Ángel García-Pérez, Antonio Cano, Ana Lluch, Pilar Eroles   +4 more
doaj   +1 more source

Polymorphisms and haplotypes of the gene encoding the estrogen-metabolizing CYP19 gene in Korean women: No association with advanced-stage endometriosis

, 2021
A variety of factors affect the development of endometriosis, including hormonal status and genetic factors. The growth of endometriosis is stimulated by local estrogen production in conjunction with circulating estrogen. The CYP19 gene encodes a steroid
정혜원, 이사라, 문혜성, 김형래   +3 more
core   +1 more source

Functional Genetic Polymorphisms in the Aromatase Gene CYP19 Vary the Response of Breast Cancer Patients to Neoadjuvant Therapy with Aromatase Inhibitors [PDF]

, 2010
Aromatase (CYP19) is a critical enzyme in estrogen biosynthesis and aromatase inhibitors (AI) are employed widely for endocrine therapy in postmenopausal women with breast cancer.
Irene Moon, Brooke L. Fridley, Aman Buzdar, Eric D. Wieben, Moon, Irene, Fridley, Brooke L., Wang, Liewei, Jenkins, Gregory D., Weinshilboum, Richard M., Katarzyna A. Ellsworth, Suman, Vera J., Eckloff, Bruce W., Ingle, James N., Anthony Batzler, Dixon, J. Michael, James N. Ingle, Vera J. Suman, Linda L. Pelleymounter, Ellsworth, Katarzyna A., Martin, Yvette N., Ravi, Saranya, Bruce W. Eckloff, William R. Miller, Buzdar, Aman, Batzler, Anthony, Miller, William R., Saranya Ravi, Pelleymounter, Linda L., Gregory D. Jenkins, Wieben, Eric D., Liewei Wang, J. Michael Dixon, Yvette N. Martin, Richard M. Weinshilboum   +33 more
core   +1 more source

A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]

, 2011
Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Mullin, B., Ingley Evan, Lewis, J., Evan Ingley, Wilson Scott G, McNab, Tegan, Jenny Z Wang, Wang, J., Wang, J.Z., Deogan, M.S., Prince, R.L., McNab Tegan J, Ben H Mullin, Chew Shelby, McNab, T.J., Chew, S., Wang Jenny Z, Mandeep S Deogan, Richard L Prince, Mullin Ben H, Scott G Wilson, Tegan J McNab, Lewis, J.R., Prince, R., Ingley, E., Prince Richard L, Deogan Mandeep S, Deogan, M., Wilson, S., Wilson, S.G., Mullin, B.H., Lewis Joshua R, Shelby Chew, Joshua R Lewis   +33 more
core   +2 more sources

Identification of SF-1 and FOXL2 and Their Effect on Activating P450 Aromatase Transcription via Specific Binding to the Promoter Motifs in Sex Reversing Cheilinus undulatus

Frontiers in Endocrinology, 2022
The giant wrasse Cheilinus undulatus is a protogynous socially hermaphroditic fish. However, the physiological basis of its sex reversal remains largely unknown.
Xinxin Ji, Shaoyang Bu, Yi Zhu, Yi Wang, Xin Wen, Feibiao Song, Jian Luo   +6 more
doaj   +1 more source

Differential expression of genes in follicular cells of swines Expressão diferencial de genes em células foliculares de suínos

Revista Brasileira de Zootecnia, 2010
The main purpose of the present study was to identify for candidate genes related to ovulation in swines. To do so, it was investigated in ovarian follicular cells through quantitative real-time PCR the differential expression of the following genes ...
Cristiana Libardi Miranda-Furtado, Priscila Vendramini Silva, Marta Fonseca Martins Guimarães, Nicola Vergara Lopes Serão, José Domingos Guimarães, Simone Eliza Facioni Guimarães   +5 more
doaj   +1 more source

Potentially Toxic Elements and Male Reproductive Toxicity: Mechanisms, Implications, and Protective Strategies: A Narrative Review

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Potentially toxic elements impair male reproductive function through oxidative stress, DNA damage, mitochondrial dysfunction, inflammation, endocrine disruption and epigenetic alterations. Antioxidants, phytochemicals, chelating agents and healthy lifestyle interventions may help mitigate testicular toxicity and preserve fertility.
Sakshi Yadav, Placheril J John
wiley   +1 more source

The T/C polymorphism of the CYP17 gene and G/A polymorphism of the CYP19 gene in endometrial cancer. [PDF]

Journal of experimental & clinical cancer research : CR, 2007
Endogenous estrogen exposure is an important determinant of endometrial cancer risk. The CYP17 and CYP19 genes encode 17 hydroxylase/17,20-lyase and aromatase, respectively, both involved in sex hormone synthesis. The gene CYP17 and CYP19 are polymorphic and gene variability could contribute to the level of protein biosynthesis. In the present work the
K, Szyllo, B, Smolarz, H, Romanowicz-Makowska, J, Lewy, B, Kulig   +4 more
openaire   +4 more sources

Insights Into the Biological Mechanisms and Multifunctional Health Benefits of Morelloflavone

eFood, Volume 7, Issue 4, August 2026.
Morelloflavone (MF), a biflavonoid from Garcinia and related species, exhibits broad human health benefits through antioxidant, anti‐inflammatory, anticancer, and metabolic regulatory effects. This review highlights its molecular mechanisms, biosynthesis, and emerging roles in chronic disease prevention, emphasizing systems biology and machine learning
Yi Liu, Ziyong Mao, Jesus Simal‐Gandara, Zi Chen, Hui Cao   +4 more
wiley   +1 more source