Results 61 to 70 of about 2,702,703 (186)

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, Volume 255, Issue 3, Page 340-361, March 2026.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Phloem Proteomics to Identify Small Open Reading Frame (sORF)‐encoded Peptides With a Putative Role in the Control of Flowering Time in Arabidopsis

Physiologia Plantarum, Volume 178, Issue 2, March/April 2026.
ABSTRACT Phloem sap proteomic studies have previously revealed that phloem sap composition varies during development and upon floral induction. Specific proteins, lipids, messenger RNAs (mRNAs), and peptides have been shown to accumulate at different developmental stages.
Irene Moreno‐Sanguino, Lucía Argente Collás, Göran Samuelsson, Gunnar Wingsle, Reyes Benlloch   +4 more
wiley   +1 more source

Estrone‐α‐2‐Deoxy‐Glucoside as a Targeted Therapy for Triple‐Negative Breast Cancer: Aromatase Inhibition and Cytotoxicity

Chemical Biology &Drug Design, Volume 107, Issue 2, February 2026.
Estrone‐α‐2DG, synthesized via a one‐pot multi‐enzyme system, selectively inhibits aromatase (IC50 = 0.101μM) and triple negative breast cancer cells (IC50 = 20.46 μM), offering a dual function therapeutic scaffold. ABSTRACT Aromatase inhibitors (AIs) are vital in the treatment of estrogen‐dependent breast cancer, especially in postmenopausal women. In
Tzu‐Yu Huang, Meng‐Ru Wang, Feng‐Pai Chou, Sheng‐Cih Huang, Po‐Yun Hsiao, Tung‐Kung Wu   +5 more
wiley   +1 more source

Sexing Frogs by Real-Time PCR: Using Aromatase (cyp19) as an Early Ovarian Differentiation Marker

, 2012
Most anurans have no identified sex-markers; therefore, alternative methods for identification of early changes in sex ratios are required. In this study, Lithobates sylvaticus and Silurana tropicalis tadpoles were sampled at different developmental ...
Robertson, C., Lanctot, Chantal., Pauli, B., Trudeau, Vance L., Velasco-Santamaría, Y.M., Navarro-Martín, Laia., Duarte-Guterman, P.   +6 more
core   +2 more sources

MOLECULAR GENETIC TESTING OF OSTEOPOROSIS SUSCEPTIBILITY IN POSTMENOPAUSAL WOMEN IN MOSCOW

Научно-практическая ревматология, 2011
Polymorphisms of 21 genes involved in the processes of bone remodeling were studied on samples of 150 to 265 postmenopausal healthy women in a control group and those of 175 to 269 patients with osteoporosis (OP).
V A Myakotkin, M Yu Krylov, I A Guseva, E V Chetina, N V Toroptsova, O A Nikitinskaya, E Yu Samarkina, L I Benevolenskaya, V A Myakotkin, M Yu Krylov, I A Guseva, E V Chetina, N V Toroptsova, O A Nikitinskaya, E Yu Samarkina, L I Benevolenskaya   +15 more
doaj   +1 more source

The in-vitro effect of gonadotropins’ type and combination on Granulosa cells gene expressions

Reproductive Biology and Endocrinology, 2022
Objective Nowadays, different modes and timing of GnRH-agonist combined with hCG trigger, for final follicular maturation, have been described. While LH + FSH are the naturally occurring final follicular maturation trigger, hCG is commonly use during ...
Yuval Yung, Adva Aizer, Sarah Tieb, Sharon Avhar Maydan, Ettie Maman, Lilach Marom Haham, Jigal Haas, Raoul Orvieto   +7 more
doaj   +1 more source

Inflammation and Oxidative Stress in Male Infertility: A Narrative Review

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Male infertility affects 8%–15% of couples, with male factors implicated in about half of cases; many remain idiopathic despite improved diagnostics. This narrative review addresses this gap by examining chronic inflammation as an underappreciated driver of sperm dysfunction that forms a bidirectional, self‐reinforcing cycle with ...
Donya Pourbagher, Rastin Bakhtiari Lafmejani, Parham Namdar, Arya Akhavan, Alireza Nikfarjam, Ali Soleimanzadeh   +5 more
wiley   +1 more source

Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health

Journal of Internal Medicine, Volume 299, Issue 1, Page 20-43, January 2026.
Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive decline. Although amyloid‐β and tau pathologies remain central to our understanding of AD, growing evidence suggests that disrupted lipid metabolism and impaired bioenergetics are closely linked to these hallmark features. Genetic, lipidomic
Silvia Maioli, Ivan Nalvarte, Maria Ankarcrona, Marianne Schultzberg, Kristen L. Zuloaga, Julen Goikolea, Pieter Jelle Visser, Bart De Strooper, Bengt Winblad, Paola Pizzo, Pete A. Williams, Patricia Rodriguez‐Rodriguez, Luana Naia   +12 more
wiley   +1 more source

THE ROLE OF AROMATASE IN THE DEVELOPMENT OF ENDOMETRIOSIS

Акушерство, гинекология и репродукция, 2017
The purpose of work – improving the efficiency of treating endometriosis by clarifying some aspects of the pathogenesis of endometriosis.Objectives of the study – determining the expression of aromatase in atopicescom and ectopic endometrium, to identify
L. V. Adamyan, M. M. Sonova, O. N. Loginova, K. N. Arslanyan   +3 more
doaj   +1 more source

The Role of Anethole in Reproductive Physiology and In Vitro Biotechnologies—A Review

Reproduction in Domestic Animals, Volume 61, Issue 1, January 2026.
ABSTRACT In vitro reproductive biotechnologies show promise for fertility preservation but still face challenges, including oxidative stress from high oxygen tension, which impairs cell viability and development. Antioxidants have been widely explored to attenuate oxidative stress during culture.
André Luiz da Conceição‐Santos, José Ricardo de Figueiredo   +1 more
wiley   +1 more source