Results 71 to 80 of about 2,702,703 (186)

Insights Into Infections and Inflammation in Prostate Cancer Development and Management: An Overview

BioMed Research International, Volume 2026, Issue 1, 2026.
Prostate cancer (PCa) represents a major public health concern and continues to be one of the leading causes of cancer‐related mortality among men worldwide. Current epidemiological projections suggest that the incidence and associated burden of PCa are likely to increase, emphasizing the importance of advancing preventive measures, improving early ...
Ensiyeh Bahadoran, Abouzar Babaei, Shahla Shahbazi, Milad Badri, Farhad Nikkhahi, Samira Sabzi, Baisakhi Banerjee   +6 more
wiley   +1 more source

Editing the CYP19 Gene in Goat Embryos Using CRISPR/Cas9 and Somatic Cell Nuclear Transfer Techniques

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) system is revolutionizing genome engineering and is expected to bring significant advancements in livestock traits, including the treatment of genetic diseases.
Kues, Wilfried, Izadi, Tayebeh, Nasr-Esfahani, Mohammad-Hossein, Safaeinejad, Zahra, Rahimi Andani, Mohsen, Jafarpour, Farnoosh, Tanhaie-vash, Nima, Hosseini Moghaddam, Seyed Hossein, Shiralian-Esfahani, Hanieh, Pirali, Ahmad, Eghbalsaied, Shahin, Hajian, Mehdi, Moradi, Reza   +12 more
core   +1 more source

The Roles of MicroRNAs, Oncogenes, and Tumor Suppressor Gene Molecular Subtypes of Breast Cancer: Therapeutic Potential of Pharmaceutical and Natural Products

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Background Breast cancer (BC) is the most common malignancy among women, with 2.3 million new cases and over 670,000 deaths annually. Despite advances in detection and therapy, relapse, metastasis, and resistance remain significant challenges. Tumor suppressor genes (TSGs) regulate abnormal cell division, whereas oncogenes, which arise from proto ...
Md. Sadikuj Jaman, Md. Maniruzzaman, Md. Rokibul Hasan Bhuiyan, Md Shajedul Haque, Irfan Ahmad   +4 more
wiley   +1 more source

Cis-acting elements regulating the placenta-specific promoter of the bovine Cyp19 gene [PDF]

Journal of Molecular Endocrinology, 2000
Abstract Cyp19 encodes aromatase cytochrome P450, the key enzyme of oestrogen biosynthesis. In the bovine placenta, the majority of Cyp19 transcripts include a 5' untranslated region which is encoded by exon 1.1; this suggests that its 5'-flanking region is the predominant placental promoter.
C, Kalbe, R, Fürbass, M, Schwerin, J, Vanselow   +3 more
openaire   +2 more sources

Investigation on Porcine Aromatase (CYP19) as a Specific Target Gene for Boar Testis

, 2012
Cytochrome P450 aromatase is the key enzyme in estrogen biosynthesis, encoded by CYP19 gene. Impairment of spermatogenesis associated with a decrease in sperm motility and inability to fertilize oocytes in mice due to the lacking of CYP19 was observed ...
Gunawan, Asep, ÇINAR, Mehmet Ulaş
core   +1 more source

POLYMORPHISMS OF THE CYP1A1, CYP1A2, CYP19, AND SULT1A1 GENES ARE NOT ASSOCIATED WITH INFERTILITY IN WOMEN WITH GENITAL ENDOMETRIOSIS

Фундаментальная и клиническая медицина, 2018
Aim. To estimate whether CYP1A1, CYP1A2, CYP19, SULT1A1 gene polymorphisms are associated with genital endometriosis in infertile women. Materials and Methods.
LARISA N. Danilova, VITALIY O. Chervov, NATALIA V. Artymuk, LYUDMILA A. Gordeeva   +3 more
doaj  

Differential genome-wide gene expression profiling of bovine largest and second-largest follicles: identification of genes associated with growth of dominant follicles

Reproductive Biology and Endocrinology, 2010
Background Bovine follicular development is regulated by numerous molecular mechanisms and biological pathways. In this study, we tried to identify differentially expressed genes between largest (F1) and second-largest follicles (F2), and classify them ...
Takahashi Toru, Hosoe Misa, Ushizawa Koichi, Hayashi Ken-Go   +3 more
doaj   +1 more source

CYP19 gene polymorphisms and the susceptibility to breast cancer in Xinjiang Uigur women

Genetics and Molecular Research, 2015
In this study, the relationship between CYP19 gene polymorphisms and breast cancer in Xinjiang Uigur women was investigated. A case-control study was designed to compare 112 Uigur breast cancer patients with 139 Uigur healthy controls. Individuals were genotyped for the CYP19 rs10046 polymorphism using polymerase chain reaction restriction fragment ...
L, Yang, X Y, Wang, Y T, Li, H L, Wang, T, Wu, B, Wang, Q, Zhao, D, Jinsihan, L P, Zhu   +8 more
openaire   +2 more sources

Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent

, 2014
Objective: Gynecomastia is a benign breast enlargement in males that affects approximately one-third of adolescents. The exact mechanism is not fully understood; however, it has been proposed that estrogen receptors and aromatase enzyme activity may play
Eren, Erdal, Sakallı Çetin, Esin, Çakır, Esra Deniz Papatya, Celik, Sevim Karakas, DEMİR, KORCAN, Korkmaz, Huseyin Anil, ÇETİN, ESİN SAKALLI, EDGÜNLÜ, TUBA, Cakir, Esra Deniz Papatya, Korkmaz, Hüseyin Anıl, Edgünlü, Tuba Gökdoğan, Karakaş, Sevim   +11 more
core   +1 more source

Changes in aromatase (CYP19) gene promoter usage in non-small cell lung cancer [PDF]

In humans, aromatase (CYP19) gene expression is regulated via alternative promoters. Activation of each promoter gives rise to a CYP19 mRNA species with a unique 5′-untranslated region. Inhibition of aromatase has been reported to downregulate lung tumor
Demura, Yoshiki, Ameshima, Shingo, Yamagishi, Masakazu, Miyamori, Isamu, 90242544, Bulun, Serdar E., Takeda, Yoshiyu, 70393238, 265, 26274, 22192, 26273, 26276, 26275, 435, 26277, Sasaki, Masato, Demura, Masashi, 40142278, 637, 00507080, Ishizaki, Takeshi   +21 more
core   +1 more source