Results 81 to 90 of about 2,702,703 (186)

The transcription of aromatase enzymes CYP119 (a,b) during development of Zebrafish (Danio rerio Hamilton, 1822) [PDF]

بوم‌شناسی آبزیان, 2019
Cytochrome P450 aromatase (CYP19) is a steroidogenic enzyme responsible for conversion of androgens to estrogens which plays a critical role in developmental sex differentiation and adult reproductive cycles in vertebrates.
Hamed Paknejad, Tayebeh Enayat Gholampour, Roghayeh Safari   +2 more
doaj  

Abdelazim and Sakiyeva endocrinopathy associated with polycystic ovary syndrome: Case reports

Journal of Family Medicine and Primary Care, 2019
Polycystic ovary syndrome (PCOS) is a multiple endocrine disorder associated with significant reproductive and metabolic manifestations. A genetic variation at the level of aromatase enzyme gene (CYP19 gene) and/or androgen receptors with subsequent ...
Ibrahim A Abdelazim, Sakiyeva Kanshaiym
doaj   +1 more source

Review of Imidazole Derivatives as Aromatase Inhibitors

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Breast cancer (BC) is the most commonly diagnosed malignancy in women globally, accounting for over 11% of all new cancer cases in female patients. Hormone receptor–positive BC relies on estrogen‐driven growth, making endocrine therapy a cornerstone of treatment. The standard clinical approach typically involves tamoxifen, a selective estrogen receptor
Haitham Al-Madhagi
wiley   +1 more source

Enhancing the Anticancer Efficacy of Polyphenols Through Lipid‐Based and Polymeric Nanoparticle Delivery Systems in Triple‐Negative Breast Cancer (TNBC)

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Breast cancer is the most common cancer among women. Triple‐negative breast cancer (TNBC) lacks hormone receptors and human epidermal growth factor receptor 2 expression and has aggressive behavior and poor prognosis; therefore, it has significant limitations and challenges in its treatment.
Nooshin Goudarzi, Ensiyeh Bahadoran, Masood Alaei, Kimia Taebi, Arian Ashrafzadeh, Arash Keshavarz Shahbaz, Sanaz Keshavarz Shahbaz, Munmun Bardhan   +7 more
wiley   +1 more source

Zebrafish sex determination and differentiation: Involvement of FTZ-F1 genes

Reproductive Biology and Endocrinology, 2005
Sex determination is the process deciding the sex of a developing embryo. This is usually determined genetically; however it is a delicate process, which in many cases can be influenced by environmental factors.
Olsson Per-Erik, von Hofsten Jonas
doaj   +1 more source

Epigenetic Modifications Influence Reproductive Traits in Small Ruminants

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
The epigenome undergoes dynamic changes shaped by the intricate interplay of genetic and environmental factors, which are crucial for individual growth and development. Recent studies suggest that factors such as nutrition, thermal stress (TS), infections, and assisted reproductive technologies (ARTs) can influence epigenetic changes in small ruminants
Galma Boneya Arero, Ozge Ozmen, Lipi Buch   +2 more
wiley   +1 more source

Association of CYP19 Gene Polymorphism with Breast Cancer in Iraqi Women

JOURNAL OF UNIVERSITY OF BABYLON for Pure and Applied Sciences, 2022
The basic enzyme in estradiol synthesis is, Aromatase, it is encoded by the gene called CYP19A1. Given the importance of estrogen in the development of Breast cancer risk, we studyt genetic polymorphisms in the CYP19A1 gene the, including rs10046, in a group of 45 patient women in Kerbala province, Iraq.
openaire   +2 more sources

Genetic variation of CYP19 (aromatase) gene influences age at onset of Alzheimer’s disease in women.

, 2009
Background/Aims: There is evidence for a higher prevalence of Alzheimer's disease (AD) in women, but whether this is due to their longer life expectancy or to biological gender-specific risk factors is unclear.
CORBO, Rosa Maria, ULIZZI, Laura, MORETTO G, SCACCHI R., GAMBINA G, BROGGIO E, Scacchi R, Ulizzi L, Corbo RM, Giuseppe Gambina, Giuseppe Moretto, Rosa Maria Corbo, Laura Ulizzi, Renato Scacchi   +13 more
core   +1 more source

Fenofibrate, a ligand for PPARα, inhibits aromatase cytochrome P450 expression in the ovary of mouse

Journal of Lipid Research, 2003
Peroxisome proliferator-activated receptors (PPARs) play important roles in the metabolic regulation of lipids including steroids. In this study, we investigated whether fenofibrate, a ligand for PPARα, could influence estrogen synthesis in vivo in the ...
Katsumi Toda, Teruhiko Okada, Chisata Miyaura, Toshiji Saibara   +3 more
doaj   +1 more source

Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish Chromosomes Are Expressed in Ovary or Brain [PDF]

, 2001
International audienceCytochrome P450 aromatase (Cyp19) is an enzyme catalyzing the synthesis of estrogens, thereby controlling various physiological functions of estrogens.
Guiguen, Yann, Evelyn Feng-Lin Chiang, Yann Guiguen, Feng-Lin Chiang, Evelyn, Postlethwait, John, Yi-Lin Yan, John Postlethwait, Yan, Yi-Lin, Chung, Bon-Chu, Bon-chu Chung   +9 more
core   +1 more source