Targeting ParPMC Susceptibility Hubs in Prunus: eEF1A as a Conserved Mediator of Plum Pox Virus Infection in Nicotiana benthamiana. [PDF]
Mol Plant PatholParPMC interactors were screened, highlighting eEF1A proteins; co‐localization and VIGS show their role in PPV infection and sharka susceptibility. ABSTRACT Sharka, caused by Potyvirus plumpoxi (plum pox virus, PPV), is the most destructive viral disease affecting Prunus species worldwide.
Polo-Oltra Á +5 more
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Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage
Фундаментальная и клиническая медицина, 2019 Aim. To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods.
I. N. Noskova +2 more
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The CYP19 RS4646 polymorphism IS related to the prognosis of stage I-II and operable stage III breast cancer. [PDF]
PLoS ONE, 2015 Aromatase, encoded by the CYP19 gene, catalyzes the final step of the conversion of androgens to estrogens. Given the critical role of CYP19 in estrogen synthesis, the potential influence of CYP19 rs4646 polymorphism on breast cancer survival, deserves ...
Xiying Shao +9 more
doaj +1 more source
Specific disruption of Tsc1 in ovarian granulosa cells promotes ovulation and causes progressive accumulation of corpora lutea. [PDF]
PLoS ONE, 2013 Tuberous sclerosis complex 1 (Tsc1) is a tumor suppressor negatively regulating mammalian target of rapamycin complex 1 (mTORC1). It is reported that mice lacking Tsc1 gene in oocytes show depletion of primordial follicles, resulting in premature ovarian
Lin Huang +11 more
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EFFECT OF CYP19 GENE ON POLYCYSTIC OVARY SYNDROME PHENOTYPE IN IRAQI WOMEN
The Iraqi Journal of Medical Sciences, 2016 Background:Ovarian androgen overproduction is the key physiopathologic feature of polycystic ovary syndrome and the bulk of evidence points to the ovary being the source of excess androgens, which appears to result from an abnormal regulation ...
Manal T. Mutib +2 more
doaj +4 more sources
Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog [PDF]
, 2021 Proper, tissue-specific regulation of CYP19, the gene encoding aromatase, the key enzyme of estrogen synthesis, is essential for reproductive processes. Here, we analyzed transcriptional regulation of the porcine CYP19 in female and male gonads and brain
Trish Berger +8 more
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Exploring the Expanding Role of Nuclear Receptor LRH-1/NR5A2 in Cell Biology and Immunity. [PDF]
Int J Cell BiolLRH‐1/NR5A2 is a member of the NR5A subfamily of nuclear receptors, acting as a crucial transcription factor involved in diverse biological processes. Although LRH‐1 has been extensively studied in vitro and in vivo, in relation to its role in embryonic development and differentiation and in adult tissue processes, such as cholesterol, glucose, and ...
Tsapalou E +5 more
europepmc +2 more sources
Diagnostic Characteristics, Histopathological and Aromatase Gene Polymorphism (rs ID-2470152) in Endometriosis Patients: A Case-control Study [PDF]
Journal of Clinical and Diagnostic Research, 2022 Introduction: Endometriosis is an oestrogen dependent gynaecological disease, having endometrial glands and stromal tissues outside the intrauterine locations.
Kusum +4 more
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The effects of the standardized extracts of on steroidogenesis pathways and aromatase activity in H295R human adrenocortical carcinoma cells [PDF]
Environmental Health and Toxicology, 2016 Objectives Aromatase inhibitors that block estrogen synthesis are a proven first-line hormonal therapy for postmenopausal breast cancer. Although it is known that standardized extract of Ginkgo biloba (EGb761) induces anti-carcinogenic effects like the ...
Mijie Kim +5 more
doaj +1 more source
Hayati Journal of Biosciences, 2021 Anadara clam shell contains high Zinc. This microelement is recognised as acting natural aromatase blocker (NAB) that capable of boosting testosterone level.
Pudji Astuti +5 more
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