Results 11 to 20 of about 2,702,703 (186)

Identification, Expression and Evolutional Analysis of Two cyp19-like Genes in Amphioxus

Animals
The mechanism of sex determination and differentiation in animals remains a central focus of reproductive and developmental biology research, and the regulation of sex differentiation in amphioxus remains poorly understood.
Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu   +4 more
doaj   +4 more sources

Analysis of aromatase (CYP19) gene in Iranian women with endometriosis [PDF]

Egyptian Journal of Medical Human Genetics, 2013
Endometriosis is a chronic, inflammatory, estrogen dependent disease that affects up to 10% of all women of fertile age. It is characterized by the presence and proliferation of functional endometrial glands and stroma outside the uterine cavity.
Saber, Hajar, Salehi, Zivar, Sadri, Saiedeh   +2 more
openaire   +3 more sources

The genomic environment around the Aromatase gene: evolutionary insights [PDF]

BMC Evolutionary Biology, 2005
Background The cytochrome P450 aromatase (CYP19), catalyses the aromatisation of androgens to estrogens, a key mechanism in vertebrate reproductive physiology. A current evolutionary hypothesis suggests that CYP19 gene arose at the origin of vertebrates,
Reis-Henriques Maria A, Santos Miguel M, Castro L Filipe C   +2 more
doaj   +2 more sources

Genetic Polymorphisms of Cyp19 and Myostatin Genes in Turkish Indigenous Sheep Breeds [PDF]

Journal of the Hellenic Veterinary Medical Society, 2018
Growth and meat production traits are very important in sheep breeding. Cyp19 gene has a major role in reproductive activity and growth due to its function in estrogen synthesis. Another gene affecting growth traits is  Myostatin (MSTN) gene, which mainly regulates skeletal muscle growth.
Akış, Iraz, Esen Gürsel, Feraye, Hacıhasanoğlu Çakmak, Neziha, Atmaca, Gizem, Yardibi, Hasret, Ateş, Atilla, Durak, Mehmet Hanifi, Öztabak, Kemal   +7 more
core   +6 more sources

Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSA^mT/mG Transgenic Mice

Cells, 2023
The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been extensively used for placenta-specific gene inactivation. In a pilot study, we observed unexpected phenotypes using this mouse strain, which prompted an extensive characterization ...
Prashanth Anamthathmakula, Philemon D. Shallie, Neha Nayak, Sabita Dhal, Jay L. Vivian, Gil Mor, Michael J. Soares, Nihar R. Nayak   +7 more
doaj   +2 more sources

Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif

Majalah Kedokteran Gigi Indonesia, 2016
Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang ...
Dahlia Herawati, Sri Kadarsih, Wayan T Artama, S. Suryono   +3 more
doaj   +2 more sources

(TTTA)n polymorphism of CYP19 (aromatase gene) in Euro- and Afro-Brazilians [PDF]

Genetics and Molecular Biology, 2004
We investigated the polymorphic tetranucleotide repeat (TTTA)n located in the fourth intron of the CYP19 gene in two Brazilian populations. The frequencies of the five common alleles (A) in Euro- and Afro-Brazilians were, respectively: seven repeats (A5),
Kátia Kvitko, Janice Corrêa de Barros Nunes, Mara Helena Hutz   +2 more
doaj   +5 more sources

Genetic variant in the CYP19 gene and recurrent spontaneous abortions

Gene Reports, 2017
Abstract Background The CYP19 gene encodes aromatase, a key cytochrome P450 enzyme that converts androgens to estrogens in the ovarian tissues of premenopausal women. A polymorphic variation C/T in the CYP19 gene, rs10046, results in modified estrogen levels through increasing aromatase activity.
Christina Koutsothanassis, Konstantinos Agiannitopoulos, Maria Georgoutsou, Konstantina Bampali, Aggeliki Hatzaki, Klea Lamnissou   +5 more
openaire   +3 more sources

Polymorphism C242T in the Cyp19 gene in meat sheep [PDF]

Brazilian Journal of Biology, 2016
The objective of this study was to evaluate the frequency of C242T polymorphism on the aromatase gene and the allelic and genotypic frequency of these variants in sheep belonging to four breed groups. Blood samples were collected from 187 animals of four
N. H. A. P. Mora, S. C. C. Silva, F. Tanamati, G. P. Schuroff, F. A. F. Macedo, E. Gasparino   +5 more
doaj   +4 more sources

Polychlorinated biphenyl exposure and CYP19 gene regulation in testicular and adrenocortical cell lines

Toxicology in Vitro, 2007
Exposure to polychlorinated biphenyls (PCBs) disturbs many estrogen-mediated biochemical processes. PCBs may cause these abnormalities by altering expression of the aromatase gene CYP19. This study demonstrated that high concentrations of PCB126 increased basal CYP19 mRNA abundance in mouse testicular Leydig I-10 cells and human adrenocortical H295R ...
Li, LA
openaire   +3 more sources