Results 11 to 20 of about 13,126 (201)

Polymorphic variation in CYP19 and the risk of breast cancer [PDF]

Carcinogenesis, 2001
The production of estrogen from androgen via the estrogen biosynthesis pathway is catalyzed by aromatase P450 (cyp19). We have assessed the frequency of allelic variants of the CYP19 intron 4 [TTTA]n repeat in 327 breast cancer cases and 253 controls from southern England. Previous studies have suggested that the [TTTA](10) repeat and [TTTA](12) repeat
Baxter, S.W., Choong, D.Y.H., Eccles, D.M., Campbell, I.G.   +3 more
core   +4 more sources

Methadone: A Substrate and Mechanism-Based Inhibitor of CYP19 (Aromatase) [PDF]

Drug Metabolism and Disposition, 2010
The peripheral conversion of testosterone to estradiol by aromatase is the primary source of endogenous estrogen in postmenopausal women. Studies indicating that placental aromatase is able to metabolize methadone to its primary metabolite, 2-ethylidene-1, 5-dimethyl-3, 3-diphenylpyrrolidin (EDDP), led us to test the hypothesis that methadone is able ...
Wenjie Jessie, Lu, Robert, Bies, Landry K, Kamden, Zeruesenay, Desta, David A, Flockhart   +4 more
openaire   +3 more sources

A polymorphic tetranucleotide repeat in the CYP19 gene and male breast cancer [PDF]

British Journal of Cancer, 2000
The CYP19 gene codes for the aromatase enzyme that is involved in the synthesis of oestrogens. This case-control study examines the relationship between a tetranucleotide repeat sequence in the CYP19 gene and the development of male breast cancer. No significant differences were found between male breast cancer cases and controls.
Young, I E, Kurian, K M, MacKenzie, M A, Kunkler, I H, Cohen, B B, Hooper, M L, Wyllie, A H, Steel, C M   +7 more
core   +6 more sources

Genomic Structure of the Porcine CYP19 Locus and Expression of the CYP19A3 Paralog [PDF]

Genes, 2021
Proper, tissue-specific regulation of CYP19, the gene encoding aromatase, the key enzyme of estrogen synthesis, is essential for reproductive processes. Here, we analyzed transcriptional regulation of the porcine CYP19 in female and male gonads and brain by 5’RACE and RT-PCR and comprehensively mapped the pig CYP19 locus by in silico analysis. Our data
Jens Vanselow, Alan J. Conley, Cynthia J. Corbin, Trish Berger   +3 more
openaire   +6 more sources

Ekspresi Gen CYP19 Aromatase, Estrogen, Androgen pada penderita Periodontitis Agresif

Majalah Kedokteran Gigi Indonesia, 2016
Kepadatan tulang tubuh ditentukan oleh gen CYP19 aromatase, hormon estrogen dan androgen. Pada periodontitis agresif terjadi perkembangan cepat kerusakan tulang alveolar, dan kerusakan tulang alveoler tersebut tidak diimbangioleh regenerasi tulang ...
Dahlia Herawati, Sri Kadarsih, Wayan T Artama, S. Suryono   +3 more
doaj   +2 more sources

CYP19 and ESR2 polymorphisms as potential culprits in cryptorchidism

Journal of Pediatric Urology
Cryptorchidism impairs sperm development and increases the risk of infertility and testicular cancer. Estrogen signalling is critical for proper descent of the testicles, and hormonal imbalances play a role in cryptorchidism. CYP19, also known as aromatase, encodes an enzyme that converts testosterone, a male sex hormone, into estradiol, the main form ...
Tubanur, Kaya Kurt, Alev, Suzen, Cilem, Ozdemir, Tuba, Edgunlu, Muhammed, Kurt, Ramazan, Gungormus   +5 more
openaire   +3 more sources

CYP17 and CYP19 gene polymorphisms in women affected with endometriosis

Fertility and Sterility, 2009
To investigate whether CYP17 T>C polymorphism and polymorphisms C1558T and Val80 of CYP19 are related to endometriosis.Clinical study.Women affected with endometriosis (n = 104) and control group (n = 86). The diagnosis of endometriosis was confirmed by the histologic examination of the endometriotic lesions.In patients affected with endometriosis, we ...
VIETRI, Maria Teresa, CIOFFI, Michele, SESSA M, SIMEONE S, BONTEMPO, Paola, TRABUCCO E, ARDOVINO M, COLACURCI, Nicola, MOLINARI, Anna Maria, COBELLIS, Luigi   +9 more
openaire   +3 more sources

Association between telomere length and CYP19 TTTA repetition polymorphism in healthy and breast cancer-diagnosed women

Breast Cancer: Targets and Therapy, 2017
Blanca Murillo-Ortiz,1 Sandra Martínez-Garza,1 David Suárez García,1 Rosa del Carmen Castillo Valenzuela,2 Juan Francisco García Regalado,2 Gerardo Cano Velázquez1 1Institute Mexican of Social Security, Department ...
Murillo-Ortiz B, Martínez-Garza S, Suárez García D, Castillo Valenzuela RDC, García Regalado JF, Cano Velázquez G   +5 more
doaj   +1 more source

Sex-Specific Gene Expression Ontogeny During Gonadal Development in Post-Metamorphic Xenopus tropicalis. [PDF]

Mol Reprod Dev
Post‐metamorphic gonadal development in Xenopus tropicalis was analyzed through integrated morphometric, histological, and transcriptional approaches. Males showed upregulation of cyp17, amh, and amhr2, whereas females exhibited an increased aldh1a2 and ddx4.
Marini D, Roza M, Berg C, Brouard V.
europepmc   +2 more sources

Association between gynecomastia and aromatase (CYP19) polymorphisms [PDF]

European Journal of Endocrinology, 2008
ObjectiveAromatase cytochrome P45019 (CYP19) is a key enzyme in estrogen biosynthesis, and polymorphisms within its gene are associated with an increased risk of estrogen-dependent diseases. Enhanced estrogen stimulation of breast tissue in men may lead to gynecomastia.
Izabella, Czajka-Oraniec, Wojciech, Zgliczynski, Alina, Kurylowicz, Michal, Mikula, Jerzy, Ostrowski   +4 more
openaire   +2 more sources