Results 121 to 130 of about 34,953 (257)

Cyp1A1 Gene Polymorphism And Polycystic Ovary Syndrome

, 2008
The aim of this study was to assess the rates of variant alleles of cytochrome P4501A1 (CYP1A1) in patients with polycystic ovary syndrome (PCOS).
Alikasifoglu, Mehmet, Yarali, Hakan, Aktas, Dilek, Tuncbilek, Ergul, Otegen, Umit, Esinler, Ibrahim, Ibrahim Esinler, Ergul Tuncbileke, Hakan Yarali, Mehmet Alikasifoglu, Dilek Aktas, Umit Otegen   +11 more
core   +1 more source

Prevalence of GSTM1*0 and CYP1A1*2A (rs4646903) variants in the central Peruvian coastal population: Pilot Study of predictive genetic biomarkers for 4P medicine [PDF]

Pharmacia
The CYP1A1 isoenzyme is responsible for the biotransformation of procarcinogens, such as Benzo(a)pyrene, into reactive metabolites. Meanwhile, GSTM1 facilitates the detoxification of these metabolites by conjugating them with glutathione. The presence of
Angel T. Alvarado, Alberto Salazar-Granara, Nelson Varela, Luis Abel Quiñones, César Li-Amenero, María R. Bendezú, Jorge A. García, Felipe Surco-Laos, Haydee Chávez, Juan J. Palomino-Jhong, Doris Laos-Anchante, Elizabeth J. Melgar-Merino, Pompeyo A. Cuba-García, Mario Bonifaz-Hernández, José Santiago Almeida-Galindo, Mario Pineda-Pérez, Mario Bolarte-Arteaga, Ricardo Pariona-Llanos   +17 more
doaj   +3 more sources

Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines

Toxicology Letters, 2013
Anthocyanins are plant pigments occurring in flowers and berry fruits. Since a phenomenon of food-drug interactions is increasingly emerging, we examined the effects of 21 major anthocyanins and the extracts from 3 food supplements containing ...
Alzbeta Kamenickova, E. Anzenbacherová, P. Pávek, A. Soshilov, M. Denison, M. Zapletalová, P. Anzenbacher, Z. Dvořák   +7 more
semanticscholar   +1 more source

Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism

, 2000
International audienceThe modulation of benzo[a]pyrene diolepoxide (BPDE)DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males.
Bartsch, Helmut, Cascorbi, Ingolf, Kopp-Schneider, Annette, Roots, Ivar, Rojas, Margarita, Kriek, Erik, Auburtin, Guy, Alexandrov, Kroum, Mayer, Lucienne   +8 more
core   +1 more source

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines

Toxicology and Applied Pharmacology, 2013
The aryl hydrocarbon receptor (AhR) is an important mediator of toxic responses after exposure to xenobiotics including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like polychlorinated biphenyls (PCBs).
Sabine U. Vorrink, P. Severson, Mikhail V. Kulak, B. Futscher, F. Domann   +4 more
semanticscholar   +1 more source

Cytochrome P450 CYP1A1: wider roles in cancer progression and prevention

BMC Cancer, 2009
CYP1A1 is one of the main cytochrome P450 enzymes, examined extensively for its capacity to activate compounds with carcinogenic properties. Continuous exposure to inhalation chemicals and environmental carcinogens is thought to increase the level of ...
V. Androutsopoulos, A. Tsatsakis, D. Spandidos   +2 more
semanticscholar   +1 more source

Sulforaphane inhibits CYP1A1 activity and promotes genotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro

, 2013
Increasing environmental pollution by carcinogens such as some of persistent organic pollutants (POPs) has prompted growing interest in searching for chemopreventive compounds which are readily obtainable.
Zhang, Chao, Liu, Weiping, Zhuang, Shulin, Yang, Fangxing, Yang, FX (reprint author), Zhejiang Univ, Coll Environm & Resource Sci, 388 Yuhangtang Rd, Hangzhou 310058, Peoples R China., Dai, Heping   +5 more
core   +1 more source

Overexpression of CYP1A1 in SL3 (HeLa GT 1b) replicon cells restores sensitivity to TGV.

, 2012
A) qPCR analysis of CYP1A1, 1A2, and 3A4 mRNA levels in 1b Rluc replicon, control SL3 HeLa 1b replicon cells, and SL3 HeLa 1b replicon CYP1A1-overexpressing cell lines. B) TGV, HCV-796, and 2′CMeA EC50s in SL3 control and CYP overexpressing cell lines.
Katherine M. Brendza (158359), Maisoun Sulfab (158366), Yang Tian (120718), James Trenkle (158388), Bin Han (45760), Johan Neyts (55640), Xiaohong Liu (50816), John Link (158398), Roman Sakowicz (79348), Magdeleine Hung (158371), Uli Schmitz (158404), Randall W. Vivian (158381), Christy M. Hebner (158355), Wanchi Fung (158375), James Taylor (158393), Michelle Nash (158363), Kyla Bjornson (158394), Steven Bondy (158396), Weidong Zhong (120728), Hengli Tang (158403)   +19 more
core   +1 more source

RETRACTED ARTICLE: In silico analysis of human CYP1A1 protein and microplastics interaction

Discover Chemistry
Microplastics (MPs) are ubiquitous environmental pollutants, raising significant concerns about their potential impacts on human health. Cytochrome P450 1A1 (CYP1A1) plays a crucial role in the biotransformation and detoxification of xenobiotics ...
Faijunnesa Rashid, Mustafizur Rahman, Mukul Chandra Sarker, Israt Jahan Tonny, Md. Arman Khan, Muhammad Ataullah   +5 more
doaj   +1 more source

Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children.

, 2011
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is
Winick, Naomi J, Collier, Anderson B, Chen, Tina T-L, Beuten, Joke, Pollock, Brad H, Tomlinson, Gail E, Swinney, Ryan M   +6 more
core   +1 more source