Results 121 to 130 of about 1,002 (150)

Molecular Characteristics of Carbaryl, a CYP1A1 Gene Inducer

Archives of Biochemistry and Biophysics, 2000
Carbaryl belongs to a series of compounds that activate the CYP1A1 gene. This study demonstrates the inability of carbaryl to compete with 2,3,7,8-tetrachlorodibenzo-p-dioxin for binding to the rat aryl hydrocarbon (dioxin) receptor. Structural and physicochemical properties of this insecticide, in relation to the requirements for binding to the aryl ...
C, Sandoz, P, Lesca, J F, Narbonne, A, Carpy   +3 more
openaire   +2 more sources

An uncommon phenotype of poor inducibility of CYP1A1 in human lung is not ascribable to polymorphisms in the AHR, ARNT, or CYP1A1 genes

Pharmacogenetics, 2000
Cigarette smoking can induce CYP1A1 in the lung. Induction requires the aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) proteins. Lung samples from seven of 75 Finnish patients who smoked until the time of surgery exhibited absent or low levels of CYP1A1 protein, mRNA and enzymatic activity, suggesting that ...
S, Anttila, X D, Lei, E, Elovaara, A, Karjalainen, W, Sun, H, Vainio, O, Hankinson   +6 more
openaire   +2 more sources

Genetic polymorphism of induction of CYP1A1 (EROD) activity

Pharmacogenetics, 1995
CYP1A1 is a cytochrome P450 which is inducible by polycyclic aromatic hydrocarbons (PAH). This induction is mediated via the Ahr locus which encodes the cytosolic Aryl hydrocarbon receptor. The induced activity of CYP1A1 can be measured in vitro by the ethoxyresorufin-O-deethylase (EROD) activity in lymphocytes after induction by benz(a)anthracene (B(a)
A, Catteau, E, Douriez, P, Beaune, N, Poisson, C, Bonaiti-Pellié, P, Laurent   +5 more
openaire   +2 more sources

CYP1A1.

IARC scientific publications, 1999
CYP1A1 plays an important role in the metabolism of polycyclic hydrocarbons that occur in the environment and several studies suggest that the genetic polymorphism of the gene may play a role in the predisposition to cancer. In order to evaluate the function of CYP1A1 in vivo as a host factor determinant of environmentally-caused cancers in humans ...
openaire   +1 more source

cDNA cloning and characterization of feline CYP1A1 and CYP1A2

Life Sciences, 2006
Deficiency of drug glucuronidation in the cat is one of the major reasons why this animal is highly sensitive to the side effects of drugs. The characterization of cytochrome P450 isoforms belonging to the CYP1A subfamily, which exhibit important drug oxidation activities such as activation of pro-carcinogens, was investigated.
Nagako, Tanaka, Taku, Miyasho, Raku, Shinkyo, Toshiyuki, Sakaki, Hiroshi, Yokota   +4 more
openaire   +2 more sources

Serum increases CYP1A1 induction by 3-methylcholanthrene

Biochemical and Biophysical Research Communications, 2002
CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcription.
Quoc-Binh, N'Guyen, Frederique, Fallone, Eric, Seree, Frederic, Fina, Pierre-Henri, Villard, Nolwen, Guigal, Michel, De Meo, Bruno, Lacarelle, Pierre-Marie, Martin, Yves, Barra   +9 more
openaire   +2 more sources

Analysis of CYP1A1 promoter function by transcription in vitro

Molecular Carcinogenesis, 1991
AbstractWe have analyzed the function of the CYP1A1 promoter using in vitro transcription. Using nuclear extracts from HeLa cells, we found that transcription from the promoter in vitro was constitutive. Transcription in vitro was not increased by prior exposure of the HeLa cells to the inducer 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin nor by the inclusion ...
L P, Wen, K W, Jones, J P, Whitlock
openaire   +2 more sources

CYP1A1 polymorphism and risk of gynecological malignancy in Japan

International Journal of Gynecological Cancer, 2003
The incidence of endometrial cancer and ovarian cancer in Japan has been increasing in recent years. Results of epidemiologic studies suggest that the onset and multiplication of these cancers are associated with estrogen. Estrogens are metabolized by cytochrome P450 1A1 (CYP1A1) and converted into catecholestrogens, which are carcinogens.
T, Sugawara, E, Nomura, T, Sagawa, N, Sakuragi, S, Fujimoto   +4 more
openaire   +2 more sources

Rat hepatic CYP1A1 and CYP1A2 induction by menadione

Toxicology Letters, 2005
The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approximately 5.4- and 2.5-fold increase ...
Y A, Sidorova, A Y, Grishanova, V V, Lyakhovich   +2 more
openaire   +2 more sources

Transcriptional and Post-Translational Regulation of CYP1A1 by Primaquine

The Journal of Pharmacology and Experimental Therapeutics, 2001
Regulation of the CYP1A1 gene has been shown to involve the aryl hydrocarbon receptor and the CYP1A1 gene expression is induced by AhR ligands. Primaquine is an antimalarial agent that does not exhibit the structural properties of a classical AhR ligand.
V, Werlinder, M, Backlund, A, Zhukov, M, Ingelman-Sundberg   +3 more
openaire   +2 more sources