Results 151 to 160 of about 15,644 (193)

Effect of troglitazone on CYP1A1 induction

Toxicology, 2008
Several peroxisome proliferators enhance CYP1A1 activity, but the mechanisms involved in this enhancement remain unknown. In this study, we examined the effect of troglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, on CYP1A1 gene expression and explored the mechanisms involved in these effects.
Hyung Gyun, Kim, Eun Hee, Han, Hye Gwang, Jeong   +2 more
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Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms

Pharmacogenetics, 2000
The genotypic basis of interindividual variation in levels of induced CYP1A1 activity has been investigated by screening both the CYP1A1 gene and the Ah receptor gene (AhR) for both previously described and novel polymorphisms. A 103-fold level of interindividual variation in induced CYPlA1 activity [ethoxyresorufin O-deethylase (EROD)] was observed in
J, Smart, A K, Daly
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Detection of CYP1A1 gene polymorphism using designed RFLP and distributions of CYP1A1 genotypes in Japanese

International Archives of Occupational and Environmental Health, 1995
Isoleucine (Ile)-valine (Val) polymorphism, which is caused by a point mutation from A to G in exon 7, is reported to be associated with an elevated risk of lung cancer among Japanese. Because CYP1A1 catalyzes bioactivation of environmental procarcinogens, such as benzo[a]pyrene, it is very important to study the clinical meaning of Ile-Val ...
T, Oyama, T, Mitsudomi, T, Kawamoto, A, Ogami, T, Osaki, Y, Kodama, K, Yasumoto   +6 more
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CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor

Pharmacogenetics, 2001
Induction of a polycyclic aromatic hydrocarbon-metabolizing cytochrome P450 isoform CYP1A1 is regulated by aromatic hydrocarbon receptor (AHR). High inducibility of CYP1A1, possibly due to genetic polymorphisms, has been considered to be a risk factor for lung cancer in tobacco smokers.
S, Anttila, P, Tuominen, A, Hirvonen, M, Nurminen, A, Karjalainen, O, Hankinson, E, Elovaara   +6 more
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CYP2D6 and CYP1A1 mutations in the Turkish population

Cell Biochemistry and Function, 2005
AbstractDrugs and carcinogens are substrates of a group of metabolic enzymes including cytochrome p450 enzymes and gluthatione S‐transferases. Many of the genes encoding these enzymes exhibit functional polymorphisms that contribute individual cancer susceptibility and drug response. Molecular studies based on these polymorphic enzymes also explain the
Muge, Aydin, Ozden, Hatirnaz, Nevin, Erensoy, Ugur, Ozbek   +3 more
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Induction of CYP1A1 by GABA Receptor Ligands

Biochemical and Biophysical Research Communications, 1996
The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the gamma-aminobutyric acid (GABA) receptor could also induce CYP1A1.
M D, Sadar, A, Westlind, F, Blomstrand, T B, Andersson   +3 more
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Genetic polymorphisms of CYP1A1 in a Korean population

Archives of Toxicology, 2004
Genetic polymorphisms in the coding exons of the CYP1A1 gene were analyzed in 100 Koreans. Three types of CYP1A1 polymorphisms, specifically G134A, G184C and A2455G, were identified with allelic frequencies of 18, 3, and 16%, respectively, and no linkage was observed among them.
Duk Woong, Park, Bohwan, Jin, Dongdeuk, Jang, Kihwa, Yang, Jung-Duck, Park, Yong-Soon, Lee, Doug-Young, Ryu   +6 more
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Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide

Biochemical and Biophysical Research Communications, 2007
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces CYP1A1 mRNA expression, and co-treatment with the protein synthesis inhibitor, cycloheximide (CHX) magnifies its expression severalfold further. Although this phenomenon has been reported as superinduction, its molecular mechanism is still obscure. In the present study, we analyzed the influence of the
Yoshinori, Sakata, Wataru, Yoshioka, Chiharu, Tohyama, Seiichiroh, Ohsako   +3 more
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CYP1A1 and CYP1B1 in Blood-Brain Interfaces: CYP1A1-Dependent Bioactivation of 7,12-Dimethylbenz(a)anthracene in Endothelial Cells

Drug Metabolism and Disposition, 2003
Immunohistochemistry and autoradiography were used to identify sites of the cytochrome P450 enzymes (P450) 1A1 and 1B1 expression and activation of 7,12-dimethylbenz(a)anthracene (DMBA), in the brain of rodents pretreated with the aryl hydrocarbon receptor (AhR) agonists beta-naphthoflavone (BNF), 3,3',4,4',5-pentachlorobiphenyl or vehicle ...
Lizette, Granberg, Anna, Ostergren, Ingvar, Brandt, Eva B, Brittebo   +3 more
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CYP1A2 is expressed along with CYP1A1 in the human lung

Cancer Letters, 2001
The expression and activity of CYP1A1 were examined in fresh, small-sized lung biopsy specimens from nine human subjects. CYP1A1 transcripts were detected by reverse transcription-polymerase chain reaction (RT-PCR) analysis of total lung RNA. CYP1A2 transcripts were detected in the RNA samples as well, and bioactivation of 2-aminofluorene (2-AF) or 2 ...
C, Wei, R J, Cacavale, J J, Kehoe, P E, Thomas, M M, Iba   +4 more
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