Results 31 to 40 of about 15,644 (193)

Inhibition of CYP1A1 by pharmaceutical drugs, omeprazol and ketoconazole as a mechanism for activation of aryl hydrocarbon receptor (AHR) [PDF]

Trends in Pharmaceutical Sciences, 2017
Omeprazole (OMP) and ketoconazole (KTZ) have been shown to activate the AHR signaling pathway in spite of the fact that they bind to the receptor with low or no affinity.
Ali Ghaffarian-Bahraman, Nilofar Sadeghimanesh, Mona Mirzaei, Amin-Reza Akbarizadeh, Mahmoud Omidi, Hamidreza Mohammadi, Mohammad-Reza Arabnezhad, Keivan Mobini, Afshin Mohammadi-Bardbori   +8 more
doaj  

Interaction between CYP1A1 gene polymorphism and environment factors on risk of endometrial cancer

Environmental Health and Preventive Medicine
Background: The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) of the CYP1A1 gene and the gene-environment interaction on the susceptibility to endometrial cancer in Chinese women.
Jian Xu, Cheng Tan
doaj   +1 more source

Polymorphisms of CYP1A1, CYP1A2, CYP19, and SULT1A1 genes in women with early miscarriage

Фундаментальная и клиническая медицина, 2019
Aim. To determine the frequency of the polymorphisms within the genes encoding estrogen metabolism enzymes: CYP1A1 (rs4646903), CYP1A2 (rs762551), CYP19 (rs700519) and SULT1A1 (rs9282861) in women with early miscarriage.Materials and Methods.
I. N. Noskova, N. V. Artymuk, L. F. Gulyaeva   +2 more
doaj   +1 more source

Racial differences in CYP1A1 genotype and function

Toxicology Letters, 1995
The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism.
E, Taioli, F, Crofts, J, Trachman, S, Bayo, P, Toniolo, S J, Garte   +5 more
openaire   +2 more sources

Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea [PDF]

Reproductive Toxicology, 2007
This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII.This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000.
Hong, Liu, Fan, Yang, Zhiping, Li, Changzhong, Chen, Zhian, Fang, Lihua, Wang, Yonghua, Hu, Dafang, Chen   +7 more
openaire   +2 more sources

Lung Cancer and CYP1A1 or GSTM1 Polymorphisms

Environmental Health and Preventive Medicine, 2003
Most chemical carcinogens are metabolized and activated in vivo by phase I enzymes including the microsomal cytochromes P450 and epoxide hydroxylases. The carcinogens and their metabolites are detoxified by phase II enzymes that include various transferases such as glutathion-S-transferases (GST).
OYAMA, Tsunehiro, KAGAWA, Norio, KIM, Yong-Dae, MATSUMOTO, Akiko, ISSE, Toyohi, KAWAMOTO, Toshihiro   +5 more
openaire   +1 more source

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site. [PDF]

PLoS ONE, 2011
BACKGROUND: We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1) monooxygenase expression in vitro. OBJECTIVE: Our purpose was (i) to identify the molecular mechanism involved and (ii) to characterize the inducer compound(s) in ...
Pierre-Henri Villard, Fabrice Barlesi, Martine Armand, Thi-Mai-Anh Dao, Jean-Marc Pascussi, Francis Fouchier, Serge Champion, Claire Dufour, Christian Giniès, Ayman Khalil, Marie-Josephe Amiot, Yves Barra, Eric Seree   +12 more
doaj   +1 more source

Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

Antioxidants, 2021
We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Using a
Maria João Correia, António B. Pimpão, Filipa Lopes-Coelho, Catarina O. Sequeira, Nuno R. Coelho, Clara Gonçalves-Dias, Robert Barouki, Xavier Coumoul, Jacinta Serpa, Judit Morello, Emília C. Monteiro, Sofia A. Pereira   +11 more
doaj   +1 more source

A Computational Strategy for Identifying Self‐Assembling Food‐Derived Molecules for Antiparasitic Nanotherapy

Advanced Science, EarlyView.
An integrated computational screening strategy identified ursolic acid (UA) and 18β‐glycyrrhetinic acid (18βGA) as a self‐assembling food‐derived molecular pair. The resulting carrier‐free nanoparticles (UA‐18βGA) showed synergistic antiparasitic activity, reduced combined toxicity, and host‐protective anti‐inflammatory effects in zebrafish and murine ...
Shenye Qu, Ting Wang, Jietao Liu, Jiacheng Qin, Bin Yang, Yihang Liu, Pengfei Li, Gaoxue Wang, Fei Ling   +8 more
wiley   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source