Results 31 to 40 of about 34,953 (257)
South African Journal of Oncology, 2021 Background: The CYP1A1 catalyses polycyclic aromatic hydrocarbons activation to reactive metabolites, causing deoxyribonucleic acid (DNA) damage and cancer. It is highly polymorphic and displays ethnic differences in various populations.
Fatima Hamad +3 more
doaj +1 more source
The CYP1A1 and GSTM1 Genetic Polymorphisms and Susceptibility to Endometriosis in Women from South India [PDF]
International Journal of Fertility and Sterility, 2008 Background Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility.
Roya Rozati +6 more
doaj +1 more source
FEBS Open Bio, 2020 Acute lung injury (ALI) is accompanied by overactivation of multiple pro‐inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (
Li‐xing Tian +8 more
doaj +1 more source
, 2022 CYP1A1 enzyme is integral to the biotransformation of polycyclic aromatic hydrocarbons to carcinogenic compounds. This study aimed to screen mutations in exon 7 (ex7) of CYP1A1 and investigate its clinicopathological correlations in fresh tissue samples ...
Aktar, S +11 more
core +1 more source
Clinical and Experimental Hypertension, 2017 Aims: To investigate the association of CYP1A1 genotype and additional gene–smoking interaction with coronary artery disease (CAD) risk based on a Chinese case-control study.
Dao-Di Peng, Wei Xie, Zai-Xin Yu
doaj +1 more source
Middle East Journal of Cancer, 2020 Background: Acute myeloid leukemia (AML) may originate from the combination of genetic susceptibility factors and environmental exposure. The aim of this study was to investigate the association of GSTM1 and GSTT1 null genotypes and CYP1A1*2A allele with
Yousef Mortazavi +6 more
doaj +1 more source
Frontiers in Immunology, 2022 BackgroundCytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism.
Sweta Ghosh +3 more
doaj +1 more source
Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain [PDF]
Cancers, 2020 Background: some types of cancer have been associated with the presence of single nucleotide polymorphisms (SNPs) of some genes that encode enzymes: glutathione-S transferase (GST), whose alteration leads to loss of function and a lower capacity to eliminate toxic GSTM1 and GSTT1 null genotypes; SNPs causing loss of function of CYP1A1 or CYP1A1–2 ...
Mariano Sánchez-Siles +10 more
openaire +2 more sources
Variation in induced CYP1A1 levels: Relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
The genotypic basis of interindividual variation in levels of induced CYP1A1 activity has been investigated by screening both the CYP1A1 gene and the Ah receptor gene (AhR) for both previously described and novel polymorphisms.
Smart J, Daly AK
core +4 more sources