Results 31 to 40 of about 1,002 (150)

Acute styrene exposure induces hepatocellular injury and molecular stress responses in Oryzias celebensis: Evidence for a tropical sentinel species in ecotoxicological monitoring [PDF]

Veterinary World
Background and Aim: Plastic-derived monomers such as styrene are increasingly detected in tropical freshwater ecosystems at concentrations approaching 0.8 mg/L.
Amelia Ramadhani Anshar, Huda Shalahudin Darusman, Wasmen Manalu, Khusnul Yaqin, Muhammad Ardiansyah Nurdin, Muhammad Reza Cordova   +5 more
doaj   +1 more source

Passive smoking, Cyp1A1 gene polymorphism and dysmenorrhea [PDF]

Reproductive Toxicology, 2007
This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII.This report includes 1645 (1124 no dysmenorrhea, 521 dysmenorrhea) nonsmoking and nondrinking newly wed female workers at Anqing, China between June 1997 and June 2000.
Hong, Liu, Fan, Yang, Zhiping, Li, Changzhong, Chen, Zhian, Fang, Lihua, Wang, Yonghua, Hu, Dafang, Chen   +7 more
openaire   +2 more sources

Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex

Antioxidants, 2021
We hypothesized that an interplay between aryl hydrocarbon receptor (AhR) and cysteine-related thiolome at the kidney cortex underlies the mechanisms of (mal)adaptation to chronic intermittent hypoxia (CIH), promoting arterial hypertension (HTN). Using a
Maria João Correia, António B. Pimpão, Filipa Lopes-Coelho, Catarina O. Sequeira, Nuno R. Coelho, Clara Gonçalves-Dias, Robert Barouki, Xavier Coumoul, Jacinta Serpa, Judit Morello, Emília C. Monteiro, Sofia A. Pereira   +11 more
doaj   +1 more source

Racial differences in CYP1A1 genotype and function

Toxicology Letters, 1995
The cytochrome P450 1A1 (CYP1A1) gene may be of critical importance in determining individual cancer susceptibility to aromatic hydrocarbons such as those in tobacco smoke. We compared the frequencies of CYP1A1 haplotypes, and complete genotypes, taking into account polymorphisms at 3 sites, including an African-specific polymorphism.
E, Taioli, F, Crofts, J, Trachman, S, Bayo, P, Toniolo, S J, Garte   +5 more
openaire   +2 more sources

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1

Journal of Immunology Research, 2022
The strong tumorigenic capacity and treatment resistance made hepatocellular carcinoma (HCC) a huge threat to public health. ZNF165, the kruppel family of zinc-finger-containing transcription factors, is expressed in HCC; however, its specific role in ...
Peng Liu, Yan Zhou, Xin Dong, Biao Zheng, Bo Liang, Rui Liang, Zhong Liu, Li Li, Peng Gong   +8 more
doaj   +1 more source

Melatonin Levels in 89 Individuals With Smith Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT In patients with Smith–Magenis syndrome (SMS), an inverted circadian rhythm of melatonin (MT) contributes to the sleep disturbance. Standard treatment of sleep disturbance with MT often leads to extremely high daytime MT levels, resulting in even more sleep disorders. We therefore retrospectively evaluated the MT data of 89 SMS patients.
Wiebe Braam, Ann C. M. Smith
wiley   +1 more source

Lung Cancer and CYP1A1 or GSTM1 Polymorphisms

Environmental Health and Preventive Medicine, 2003
Most chemical carcinogens are metabolized and activated in vivo by phase I enzymes including the microsomal cytochromes P450 and epoxide hydroxylases. The carcinogens and their metabolites are detoxified by phase II enzymes that include various transferases such as glutathion-S-transferases (GST).
OYAMA, Tsunehiro, KAGAWA, Norio, KIM, Yong-Dae, MATSUMOTO, Akiko, ISSE, Toyohi, KAWAMOTO, Toshihiro   +5 more
openaire   +1 more source

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications

British Journal of Clinical Pharmacology, EarlyView.
Dolutegravir underpins modern first‐ and second‐line HIV treatment regimens; however, interindividual variability in its disposition and tolerability presents challenges for optimal use. This scoping review mapped current evidence on the pharmacogenomics of dolutegravir, focusing on pharmacokinetics and pharmacodynamics, and methodological limitations ...
Ronald Kiguba, Mishael Ssesanga, Munir Pirmohamed   +2 more
wiley   +1 more source

CYP1A1 induction in the colon by serum: involvement of the PPARα pathway and evidence for a new specific human PPREα site. [PDF]

PLoS ONE, 2011
BACKGROUND: We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1) monooxygenase expression in vitro. OBJECTIVE: Our purpose was (i) to identify the molecular mechanism involved and (ii) to characterize the inducer compound(s) in ...
Pierre-Henri Villard, Fabrice Barlesi, Martine Armand, Thi-Mai-Anh Dao, Jean-Marc Pascussi, Francis Fouchier, Serge Champion, Claire Dufour, Christian Giniès, Ayman Khalil, Marie-Josephe Amiot, Yves Barra, Eric Seree   +12 more
doaj   +1 more source

Reprogramming tumor immune microenvironment by ultrasound‐responsive nanoplatforms for enhanced cancer immunotherapy

BMEMat, EarlyView.
Ultrasound‐responsive nanoplatforms reprogram the tumor immune microenvironment by targeting tumor cells, immune cells, and non‐immune stromal cells to enhance the efficacy of cancer immunotherapy. Abstract Cancer immunotherapy represents a significant advancement in cancer treatment by enhancing the specific recognition and elimination of cancer cells.
Shilong Zhao, Rui Qu, Zan Dai, Xiqun Jiang, Xu Zhen   +4 more
wiley   +1 more source