Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice [PDF]
Drug Metabolism and Disposition, 2019 Cytochrome P450s CYP1A1 and CYP1A2 can metabolize a broad range of foreign compounds and drugs. However, these enzymes have significantly overlapping substrate specificities.
Y. Kapelyukh +4 more
semanticscholar +6 more sources
CYP1A1*2 and CYP1A1*3 Polymorphisms cosegregate in the Indian Population
Anthropologischer Anzeiger, 2002 Several ethnic groups have been genotyped for polymorphisms at the CYP1A1 gene locus that encodes the enzyme that catalyzes the initial step in the metabolism of polycyclic aromatic hydrocarbons. Two of the CYP1A1 polymorphisms, namely, CYP1A1*2 and CYP1A1*3 are reported to cosegregate among the Japanese and to a lesser extent in Caucasians, but not in
Aparna, Kotekar, Rajani, Bhisey
core +4 more sources
Tissue-specific variability in protein expression of cytochrome P450 and glutathione S-transferase isoenzymes in non-small cell lung carcinoma [PDF]
Arhiv za Higijenu Rada i ToksikologijuEarlier tissue-based studies report heterogeneous CYP and GST protein expression in non-small cell lung cancer (NSCLC), but simultaneous assessment of phase I and II enzymes in paired tumour and peripheral normal tissues remains limited and their ...
Kılıç Murat +6 more
doaj +2 more sources
CYP1A1 Variability In Human Populations [PDF]
Collegium antropologicum, 2019 The human cytochrome P4501A1 (CYP1A1) enzyme plays an important role in the metabolism of xenobiotics and endogenous substrates. Because polymorphisms within the CYP1A1 gene have been shown to be associated with various cancer risks and with the predicting clinical efficacy of some chemotherapies in different populations, most studies focus on their ...
Martinez-Labarga C. +13 more
core +6 more sources
Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter [PDF]
Frontiers in Pharmacology, 2018 Pigs are commonly used as an animal model to evaluate the toxic effects of exogenous compounds. Cytochrome P450 1A1 (CYP1A1) metabolizes numerous exogenous compounds and is abundantly expressed in the liver, kidneys, and intestines.
Xuan Xie +11 more
doaj +2 more sources
Induction of CYP1A1 by GABA Receptor Ligands
Biochemical and Biophysical Research Communications, 1996 The induction of CYP1A1 is mediated via the aromatic hydrocarbon (Ah) receptor. Studies from our laboratory show CYP1A1 induction by picrotoxin and phenobarbital which prompted us to examine if other ligands of the gamma-aminobutyric acid (GABA) receptor could also induce CYP1A1.
M D, Sadar +3 more
openaire +3 more sources
Smokeless Tobacco‐Associated Nitrosamines Impact on Aryl Hydrocarbon Receptor: In Silico and In Vitro Study [PDF]
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.Schematic representation of STE (smokeless tobacco extract) impact on AhR and AhR‐related genes. TSNAs present in STE induce AhR that results in to AhR conformational changes and translocation to the nucleus. Inside the nucleus, AhR heterodimerizes with Arnt and binds to XRE region of genome.
Mohammad Sajid +5 more
wiley +2 more sources
CYP2D6 and CYP1A1 mutations in the Turkish population
Cell Biochemistry and Function, 2005 AbstractDrugs and carcinogens are substrates of a group of metabolic enzymes including cytochrome p450 enzymes and gluthatione S‐transferases. Many of the genes encoding these enzymes exhibit functional polymorphisms that contribute individual cancer susceptibility and drug response. Molecular studies based on these polymorphic enzymes also explain the
Muge, Aydin +3 more
openaire +3 more sources
Inhibition of CYP1A1 Alleviates Colchicine-Induced Hepatotoxicity
ToxinsColchicine, a natural compound extracted from Colchicum autumnale, is a phytotoxin, but interestingly, it also has multiple pharmacological activities.
Ruoyue Huang +5 more
doaj +3 more sources
MiR‐18a‐5p Attenuates Oxidative Stress and Inhibits Lipid Accumulation in Alcoholic Fatty Liver by Activating the CYP1A1‐PPAR Axis [PDF]
Immunity, Inflammation and DiseaseBackground Lipid deposition in alcoholic fatty liver disease (AFL) represents an early stage in alcoholic liver disease progression and may contribute to carcinogenesis.
XueMei Zhang +10 more
doaj +2 more sources