Results 11 to 20 of about 15,644 (193)

Induction of pulmonary CYP1A1 by nicotine [PDF]

Xenobiotica, 1998
1. We have examined the catalytic activities (7-ethoxyresorufin O-deethylase [EROD] and 7-methoxyresorufin O-demethylase [MROD]), protein levels (Western blot analysis) and mRNA levels (Northern blot analysis) of cytochrome P4501A (CYP1A1 and CYP1A2) in the lung, liver and kidney following a single 2.5 mg/kg (15.4 micromol/kg) subcutaneous dose of ...
M M, Iba, H, Scholl, J, Fung, P E, Thomas, J, Alam   +4 more
openaire   +3 more sources

Association of CYP1A1*2A Polymorphism with Idiopathic Non-Obstructive Azoospermia in A South Indian Cohort [PDF]

International Journal of Fertility and Sterility, 2017
Background: Infertility is the inability of a couple to conceive after one and a half years of unprotected sex. Male infertility, which accounts for almost half of infertility cases, is considered as a major problem all over the world.
Shalaka S Ramgir, Nishu Sekar, Divya Jindam., Abilash V.G.   +3 more
doaj   +1 more source

Potential of Inactivated Bifidobacterium Strain in Attenuating Benzo(A)Pyrene Exposure-Induced Damage in Colon Epithelial Cells In Vitro

Toxics, 2020
Long-term exposure to benzo(a)pyrene (BaP) poses a serious genotoxic threat to human beings. This in vitro study investigated the potential of inactivated Bifidobacterium animalis subsp.
Mengfan Xu, Lili Fu, Junwen Zhang, Tao Wang, Junfeng Fan, Baoqing Zhu, Piotr Dziugan, Bolin Zhang, Hongfei Zhao   +8 more
doaj   +1 more source

Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Cell Communication and Signaling, 2020
The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear.
Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping Liang   +11 more
doaj   +1 more source

SNP genes of immune response mediators and predisposition to development of socially significant diseases

Медицинская иммунология, 2022
Allele typing of single-nucleotide polymorphisms (SNPs) may be used in predictive medicine and to determine targets for the most effective treatment strategies for various diseases.
E. A. Tatarkova, A. R. Tuguz, D. S. Shumilov, D. V. Muzhenya, K. A. Rudenko, I. V. Smolkov   +5 more
doaj   +1 more source

The CYP1A1 and GSTM1 Genetic Polymorphisms and Susceptibility to Endometriosis in Women from South India [PDF]

International Journal of Fertility and Sterility, 2008
Background Endometriosis is one of the most commonly encountered benign problems in gynaecology. It is frequently associated with chronic pelvic pain, dysmenorrhoea, menorrhagia and dyspareunia, which lead to infertility.
Roya Rozati, Satyanarayana Reddy, Simha Baludu Giragalla, Hamid Bakshi, Srikanth Doddmaneni, Nasaruddin Khaja, Radhey Sham Sharma   +6 more
doaj   +1 more source

Cytochrome P450 1A1 is essential for the microbial metabolite, Urolithin A-mediated protection against colitis

Frontiers in Immunology, 2022
BackgroundCytochrome P450 Family 1 Subfamily A Member 1 (CYP1A1) pathway, which is regulated by aryl hydrocarbon receptor (AhR) plays an important role in chemical carcinogenesis and xenobiotic metabolism.
Sweta Ghosh, Bhagavatula Moorthy, Bodduluri Haribabu, Venkatakrishna Rao Jala   +3 more
doaj   +1 more source

Knockout of cytochrome P450 1A1 enhances lipopolysaccharide‐induced acute lung injury in mice by targeting NF‐κB activation

FEBS Open Bio, 2020
Acute lung injury (ALI) is accompanied by overactivation of multiple pro‐inflammatory factors. Cytochrome P450 1A1 (CYP1A1) has been shown to aggravate lung injury in response to hyperoxia. However, the relationship between CYP1A1 and lipopolysaccharide (
Li‐xing Tian, Xin Tang, Wei Ma, Jing Wang, Wei Zhang, Kuan Liu, Tao Chen, Jun‐yu Zhu, Hua‐ping Liang   +8 more
doaj   +1 more source

Role of Glutathione S-transferase (GSTM1, GSTT1) and CYP1A1 (cytochrome p450) Gene Polymorphisms in Susceptibility to Acute Myeloid Leukemia

Middle East Journal of Cancer, 2020
Background: Acute myeloid leukemia (AML) may originate from the combination of genetic susceptibility factors and environmental exposure. The aim of this study was to investigate the association of GSTM1 and GSTT1 null genotypes and CYP1A1*2A allele with
Yousef Mortazavi, Robab Rahimi, Fatemeh Azimi, Shahrbano Rostami, Minoosh Moghimi, Soghrat Faghihzadeh, Saeide Mazloomzadeh   +6 more
doaj   +1 more source

Genotype of Null Polymorphisms in Genes GSTM1, GSTT1, CYP1A1, and CYP1A1*2A (rs4646903 T>C)/CYP1A1*2C (rs1048943 A>G) in Patients with Larynx Cancer in Southeast Spain [PDF]

Cancers, 2020
Background: some types of cancer have been associated with the presence of single nucleotide polymorphisms (SNPs) of some genes that encode enzymes: glutathione-S transferase (GST), whose alteration leads to loss of function and a lower capacity to eliminate toxic GSTM1 and GSTT1 null genotypes; SNPs causing loss of function of CYP1A1 or CYP1A1–2 ...
Mariano Sánchez-Siles, Juan Pablo Pelegrín-Hernández, Diego Hellin-Meseguer, Yolanda Guerrero-Sánchez, Andrés Corno-Caparrós, Juan Cabezas-Herrera, Francisco Pastor-Quirante, Juan Alberto Fernández-Ruiz, Alfonso Aliaga-Sánchez, Mayra Lucero-Berdugo, Fabio Camacho-Alonso   +10 more
openaire   +2 more sources