Results 91 to 100 of about 9,202 (195)

Data from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

, 2023
<div>Abstract<p>In this study, we used a bioinformatic approach to identify genes whose expression is dysregulated in human prostate cancers. One of the most dramatically downregulated genes identified encodes CYP27A1, an enzyme involved in regulating cellular cholesterol homeostasis.
Stephen J. Freedland, Donald P. McDonnell, Jen-Tsan Chi, Ching-yi Chang, Michael R. Freeman, Laura G. Dubois, J. Will Thompson, Joseph Geradts, Everardo Macias, Jeffery S. Jasper, Rachid Safi, Wen Liu, Erik R. Nelson, Mahmoud A. Alfaqih   +13 more
openaire   +1 more source

Nano‐plastics disrupt systemic metabolism by remodeling the bile acid–microbiota axis and driving hepatic–intestinal dysfunction

iMeta, Volume 5, Issue 1, February 2026.
The pervasiveness of microplastic pollution poses a growing health risk, yet its long‐term metabolic consequences remain poorly defined. Here, we exposed mice to polyethylene terephthalate nanoparticle (NP) and combined histopathology, biochemistry, metabolomics, and metagenomics to resolve their interactions.
Yi Zhang, Zheng Lin, Runtong Huang, Yang Zhang, Lei Wang, Zan Fu, Chao Wang, Shuai Xiao, Heru Pramono, Kui Xu, Zhimin Xu, Yulong Yin   +11 more
wiley   +1 more source

Novel splice-affecting variants in CYP27A1 gene in two Chilean patients with Cerebrotendinous Xanthomatosis

Genetics and Molecular Biology, 2015
Cerebrotendinous Xanthomatosis (CTX), a rare lipid storage disorder, is caused by recessive loss-of-function mutations of the 27-sterol hydroxylase (CYP27A1), producing an alteration of the synthesis of bile acids, with an accumulation of cholestanol ...
Susan V. Smalley, Yudith Preiss, José Suazo, Javier Andrés Vega, Isidora Angellotti, Carlos F. Lagos, Enzo Rivera, Karin Kleinsteuber, Javier Campion, J. Alfredo Martínez, Alberto Maiz, José Luis Santos   +11 more
doaj   +1 more source

Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate [PDF]

, 2014
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of ...
Kakiyama, Genta, Kim, Jin Koung, Min, Hae-Ki, Ning, Yanxia, Pandak, William M., Ren, Shunlin, Rodriguez-Agudo, Daniel   +6 more
core   +3 more sources

Bile Acid Receptor Therapeutics Effects on Chronic Liver Diseases [PDF]

, 2020
In the past ten years, our understanding of the importance of bile acids has expanded from fat absorption and glucose/lipid/energy homeostasis into potential therapeutic targets for amelioration of chronic cholestatic liver diseases.
Alpini, Gianfranco, Francis, Heather, Kennedy, Lindsey, Kundu, Debjyoti, Meadows, Vik   +4 more
core   +1 more source

Bile Acid Binding Resins Improve Glucagon Receptor Agonist‐Mediated Weight Loss in Diet‐Induced Obese Mice

Obesity, Volume 34, Issue 2, Page 428-438, February 2026.
ABSTRACT Objective Glucagon‐receptor (GCGR) agonism reguglates bile acid (BA) metabolism and promotes weight loss in diet‐induced obese (DIO) mice. Thus, we hypothesized that BA signaling contributes to GCGR‐stimulated weight loss. Methods To test this hypothesis, we utilized BA‐binding resins (BARs; colesevelam [Colsv] and cholestyramine [Cstyr]) to ...
Teayoun Kim, Mackenzie J. Pearson, Huixian Hong, Shelly Nason, Khadija Seck, Jessica Antipenko, Natalie Presedo, Richard DiMarchi, William C. Roell, Kirk Habegger   +9 more
wiley   +1 more source

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism

Journal of Pharmacy and Bioallied Sciences, 2011
It is well known that drug disposition and response are greatly determined by the activities of drug metabolizing enzymes, which are polymorphic.
Vera Dias, V Ribeiro
doaj   +1 more source

Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival [PDF]

, 2016
Single nucleotide polymorphisms (SNPs) in the vitamin D pathway genes have been implicated in cutaneous melanoma (CM) risk, but their role in CM disease-specific survival (DSS) remains obscure.
Amos, Christopher I., Feng, Shenying, Han, Jiali, Lee, Jeffrey E., Liu, Hongliang, Wei, Qingyi, Wu, Wenting, Yi, Xiaohua, Yin, Jieyun   +8 more
core   +1 more source

Therapeutic potential of tetrahydroxylated bile acids in reducing liver injury: Insights from the Zfyve19−/− mouse model

Pediatric Investigation, Volume 10, Issue 1, Page 60-69, February 2026.
THBA (3α,6α,7α,12α‐Tetrahydroxy‐10β,13β‐pentanoic acid) administration can alleviate cholestatic liver injury, hepatocellular necrosis, inflammatory response, bile duct hyperplasia, and portal fibrosis in the Zfyve19−/− mouse model. This evaluation encompasses various parameters, including serum biochemistry, liver histology, immunostaining, and ...
Li Wang, Yue Yu, Jiayan Feng, Yanan Zhang, Renxue Wang, Huiyu She, Teng Liu, Victor Ling, Jianshe Wang   +8 more
wiley   +1 more source

24s-Hydroxycholesterol. Studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration [PDF]

, 2010
Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC).
Shafaati, Marjan
core