Results 81 to 90 of about 6,856 (158)
Journal of Lipid Research, 2013 The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali +9 more
doaj +1 more source
Functional analysis of CYP27A1 in the nervous system
CYP27A1(cholesterol hydroxylase) is a key enzyme in cholesterol metabolism, critical for bile acid(BA) synthesis and lipid homeostasis. Dysfunction in CYP27A1 disrupts BA and lipid metabolism, leading to a rare autosomal recessive lipid storage disease ...
Hu, Hao
core +1 more source
Supplementary Figure S2 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
, 2017 Evaluation of CYP27A1 expression in PC ...
Erik R. Nelson (12035807) +13 more
core +1 more source
, 2003 The metabolism of 25-hydroxyvitamin D(3) was studied with a crude mitochondrial cytochrome P450 extract from pig kidney and with recombinant human CYP27A1 (mitochondrial vitamin D(3) 25-hydroxylase) and porcine CYP2D25 (microsomal vitamin D(3) 25 ...
Wikvall, Kjell, +3 more
core +1 more source
, 2002 It has been reported that there is a coordinate regulation of sterol 27-hydroxylase (CYP27A1) and cholesterol 7_-hydroxylase (CYP7A1) in rats. Thus, the levels of the mRNA corresponding to these two enzymes were found to change in the same direction in ...
Bjorkhem, I +5 more
core +1 more source
Four novel CYP27A1 mutations in seven Italian patients with CTX
, 2010 BACKGROUND AND PURPOSE: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disease, because of sterol 27-hydroxylase deficiency. Clinical manifestations of CTX are tendon xanthomas, juvenile cataracts, osteoporosis, diarrhoea and ...
Mignarri, A. +6 more
core +1 more source
Supplementary Figure S1 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
, 2017 LDL enhances PC cell growth and assessment of CYP27A1 expression levels in different stages of ...
Erik R. Nelson (12035807) +13 more
core +1 more source
Expression of CYP27A1, CYP2R1 and VDR in equine cryptorchid testis
, 2022 A functional vitamin D (VitD) requires a double step bioactivation by six cytochrome P450 (CYP) isoforms. The first step happens in the liver by four D-25-hydroxylase enzymes, among them the most active are CY27A1 and CYP2R1; the activation pathway ...
Salvatore Desantis +4 more
core
, 2005 CYP27A1 (sterol 27-hydroxylase) catalyses an important sterol elimination pathway in the human macrophage, and consequently may protect against atherosclerosis. We studied the expression and regulation of CYP27A1 in a human macrophage-like cell-line, THP-
L Kritharides (13296969) +4 more
core
Supplementary Figure S5 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer
, 2017 CYP27A1/27HC axis inhibits growth of PC cells via depletion of cellular ...
Erik R. Nelson (12035807) +13 more
core +1 more source