Results 61 to 70 of about 5,760 (129)

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Advanced Science
Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects.
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang   +7 more
doaj   +1 more source

Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis

Journal of Lipid Research, 2004
There are two major pathways of bile acid synthesis: the “neutral” pathway, initiated by highly regulated microsomal cholesterol 7α-hydroxylase (CYP7A1), and an “alternative” pathway, initiated by mitochondrial sterol 27-hydroxylase (CYP27A1).
Shunlin Ren, Phillip Hylemon, Dalila Marques, Elizabeth Hall, Kaye Redford, Gregorio Gil, William M. Pandak   +6 more
doaj   +1 more source

2 Novel deletions of the sterol 27-hydroxylase gene in a Chinese Family with Cerebrotendinous Xanthomatosis

BMC Neurology, 2011
Background Cerebrotendinous xanthomatosis (CTX) is a rare lipid-storage disease. We investigated the clinic manifestation, histopathology and sterol 27-hydroxylase gene (CYP27A1) in a Chinese family with Cerebrotendinous Xanthomatosis (CTX).
Tian Di, Zhang Zai-qiang
doaj   +1 more source

Clinical and genetic analysis of a family with cerebrotendinous xanthomatosis

Frontiers in Neurology
ObjectiveThis study aims to analyze the clinical and genetic characteristics of cerebrotendinous xanthomatosis (CTX) in a Chinese family.MethodsClinical data, including medical history, neurologic and auxiliary examinations, imaging studies, and genetic ...
You Guoliang, Wang Zhaoxia, Zhang Lin, Chen Xuan, Zhang Xiaodong, Xing Xiaolian, Su Yangli, Zhang Tianli, Zhu Yanping, Wang Jiangping, Liu Qing   +10 more
doaj   +1 more source

On the regulatory role of side-chain hydroxylated oxysterols in the brain. Lessons from CYP27A1 transgenic and Cyp27a1−/− mice1

Journal of Lipid Research, 2013
The two oxysterols, 27-hydroxycholesterol (27OH) and 24S-hydroxycholesterol (24OH), are both inhibitors of cholesterol synthesis and activators of the liver X receptor (LXR) in vitro.
Zeina Ali, Maura Heverin, Maria Olin, Jure Acimovic, Anita Lövgren-Sandblom, Marjan Shafaati, Ann Båvner, Vardiella Meiner, Eran Leitersdorf, Ingemar Björkhem   +9 more
doaj   +1 more source

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Identification of gene signatures and molecular mechanisms underlying the mutual exclusion between psoriasis and leprosy

Scientific Reports
Leprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their mutual exclusion have not been extensively investigated. This study aimed to reveal the underlying mechanism responsible for the mutual exclusion between psoriasis ...
You-Wang Lu, Rong-Jing Dong, Lu-Hui Yang, Jiang Liu, Ting Yang, Yong-Hong Xiao, Yong-Jun Chen, Rui-Rui Wang, Yu-Ye Li   +8 more
doaj   +1 more source

Influence of farnesoid X receptor (<i>FXR</i>) on lipid metabolism in calf hepatocytes exposed to high fatty acid levels. [PDF]

Front Vet Sci
Jia B, Tian Y, Gao C, Chang Y, Zhang Z, Song Y, Xia C, Qu Y, Yang W.   +8 more
europepmc   +1 more source

Correction: Integrative multi-omics and machine learning reveals the spatial niche distribution and role of CYP27A1+TAMs in immunotherapy response in non-small cell lung cancer. [PDF]

Front Immunol
Liu Q, Liu X, Zhang H, Jiang Y, Shi Y, Mu Q, Jing Y, Sun D.   +7 more
europepmc   +1 more source