Results 61 to 70 of about 6,856 (158)

The Role of Gut Microbiota in Liver Regeneration After Partial Hepatectomy: New Evidence From Animal and Human Studies

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Partial hepatectomy (PH) reshapes gut microbiota composition, resulting in the release of microbial metabolites and components, including short chain fatty acids (SCFAs)/β‐hydroxybutyric acid (BHB), bacterial DNA and extracellular vesicles (EVs), bile acids (deoxycholic acid, DCA), and aminobenzoate degradation products.
Roberto Loi, Gabriella Simbula, Andrea Caddeo, Monica Pibiri   +3 more
wiley   +1 more source

Supplementary Table S1-S3 from CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer

, 2017
Table S1. CYP27A1 transcript is down-regulated in primary prostate tumors. Table S2. CYP27A1 transcript is down-regulated in metastatic PC relative to primary tumors. Table S3.
Erik R. Nelson (12035807), Michael R. Freeman (153526), Mahmoud A. Alfaqih (14928213), Everardo Macias (14884124), Rachid Safi (81663), Jeffery S. Jasper (14928216), Stephen J. Freedland (7926608), Laura G. Dubois (562976), Wen Liu (39804), J. Will Thompson (202608), Donald P. McDonnell (15299), Jen-Tsan Chi (48985), Ching-yi Chang (15295), Joseph Geradts (65246)   +13 more
core   +1 more source

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, Volume 40, Issue 7, Page 4041-4055, July 2026.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

NPC1L1 Drives Osteoporosis by Activating the C/EBPα/Cyp27a1/27‐Hydroxycholesterol Axis: A Novel Therapeutic Target for Bone Loss

FASEB BioAdvances
This study investigated how NPC1L1, a cholesterol transporter, regulates osteogenic differentiation through cholesterol metabolism independently of its transport function.
Bohao Li, Wuling Zhou, Yueming Yu, Boyu Chen, Zhicheng Lv, Jiarui Zhang, Tieqi Zhang, Shiwei Sun, Lei Zhou, Minghai Wang   +9 more
doaj   +1 more source

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

Frontiers in Pharmacology, 2018
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis.
Nicole El-Darzi, Artem Astafev, Natalia Mast, Aicha Saadane, Morrie Lam, Irina A. Pikuleva   +5 more
doaj   +1 more source

Effects of Common Food Additives Kappa‐, Iota‐ and Lambda‐Carrageenans on Intestinal Epithelial Cell Activation and Barrier Disruption

Clinical &Experimental Allergy, Volume 56, Issue 7, Page 769-783, July 2026.
Carrageenans, widely used food additives, disrupted intestinal epithelial integrity in a gut‐on‐a‐chip model. All types (κ‐, ɩ‐, λ‐) induced cytotoxicity, inflammation and tight junction (TJ) disruption, triggering TNF‐mediated immune responses. λ‐Carrageenan had the most severe effects, supporting the Epithelial Barrier Theory linking food additives ...
Na Sun, Yagiz Pat, Huseyn Babayev, Sena Ardicli, Ismail Ogulur, Xianting Bu, Manru Li, Shuqi Jia, Beate Rückert, Raja Dhir, Kari C. Nadeau, Mubeccel Akdis, Cezmi A. Akdis, Duygu Yazici   +13 more
wiley   +1 more source

A Complete Telomere‐To‐Telomere Assembly of Plectropomus leopardus and Phylogenomic Insights Into Perciformes

Evolutionary Applications, Volume 19, Issue 7, July 2026.
ABSTRACT The leopard coral grouper, Plectropomus leopardus Lacepède, 1802, is an ecologically and economically important species in the family Epinephelidae. However, the absence of a complete reference genome has impeded advanced genetic research on this species, and the phylogenetic position of Epinephelidae within Perciformes remains unresolved ...
Baojun Zhao, Chaofan Jin, Mingjian Liu, Haizhan Tang, Da Zheng, Mengya Wang, Bo Wang, Zhenmin Bao, Jingjie Hu   +8 more
wiley   +1 more source

Genetic variants in the vitamin D pathway genes are predictors of the risk of diabetic kidney disease in Central Asian Kazakhstani cohort with type 2 diabetes

Frontiers in Medicine
IntroductionDiabetic kidney disease (DKD) is a common microvascular complication of type 2 diabetes mellitus (T2DM). Given vitamin D’s roles in glucose metabolism and renal function, this study investigated associations between common variants in vitamin
Binura Taurbekova, Abay Tursunov, Aida Kabibulatova, Alimzhan Muxunov, Assel Issabayeva, Kuralay Atageldiyeva, Kuralay Atageldiyeva, Kamilya Sydykova, Aigul Durmanova, Akbayan Markabayeva, Andrey Starodubov, Kymbat Mukhtarova, Wassim Y. Almawi, Antonio Sarria-Santamera   +13 more
doaj   +1 more source

Androgen receptor-mediated regulation of the anti-atherogenic enzyme CYP27A1 involves the JNK/c-jun pathway

, 2011
CYP27A1, an enzyme with several important roles in cholesterol homeostasis and vitamin D3 metabolism, has been ascribed anti-atherogenic properties. This study addresses an important problem regarding how this enzyme, involved in cholesterol metabolism ...
Wikvall, Kjell,, Hanna Pettersson, Wanjin Tang, Norlin, Maria,, Maria Norlin, Kjell Wikvall, Pettersson, Hanna,, Tang, Wanjin,   +7 more
core   +1 more source

Adrenal High‐Expressional CYP27A1 Mediates Bile Acid Increase and Functional Impairment in Adult Male Offspring by Prenatal Dexamethasone Exposure

Advanced Science
Prenatal dexamethasone exposure (PDE) can impact adrenal corticosteroid synthesis in adult offspring. Furthermore, the adrenal gland can autonomously synthesize bile acids, but local bile acids accumulation has cytotoxic effects.
Jiangang Cao, Wen Hu, Yawen Chen, Aihemaitijiang Ailikaiti, Ziyi Zhang, Lingbo Rong, Hong Yu, Hui Wang   +7 more
doaj   +1 more source