Results 91 to 100 of about 9,315 (207)

Cathelicidin preserves intestinal barrier function in polymicrobial sepsis. [PDF]

, 2020
ObjectivesThe intestinal epithelium compartmentalizes the sterile bloodstream and the commensal bacteria in the gut. Accumulating evidence suggests that this barrier is impaired in sepsis, aggravating systemic inflammation. Previous studies reported that
Chan, Hung, Chan, Matthew TV, Cho, Chi H, Gallo, Richard L, Gin, Tony, Ho, Idy HT, Ho, Jeffery, Hu, Wei, Leung, Czarina CH, Li, Qing, Liang, Yonghao, Ling, Lowell, Liu, Xiaodong, Tse, Gary, Ugwu, Felix N, Wong, Sunny H, Wong, Wai Tat, Wu, William KK, Yau, Johnny CW, Yu, Jun, Zeng, Judeng, Zhang, Lin, Zhang, Yuchen   +22 more
core   +1 more source

Two Membrane-Associated Tyrosine Phosphatase Homologs Potentiate C. elegans AKT-1/PKB Signaling [PDF]

, 2011
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB functions in an insulin-like signaling pathway to ...
Hu, Patrick J, Ruvkun, Gary B., Xu, Jinling   +2 more
core   +1 more source

Integration of single‐cell and bulk transcriptomics reveals the association of manganese metabolism‐related genes with prognosis and immune infiltration in lung adenocarcinoma

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
This study developed a prognostic model for lung adenocarcinoma using manganese metabolism‐related genes (MRGs). Nine key MRGs were identified via multi‐omics and LASSO‐Cox analyses to calculate a risk score. The model showed robust predictive performance in both training and validation cohorts.
Hongliang Li, Shuzhen Wei, Wei Li, Junxia Sun, Yi Wang   +4 more
wiley   +1 more source

Ethnic differences in the prevalence of polymorphisms in CYP7A1, CYP7B1 AND CYP27A1 enzymes involved in cholesterol metabolism

Journal of Pharmacy and Bioallied Sciences, 2011
It is well known that drug disposition and response are greatly determined by the activities of drug metabolizing enzymes, which are polymorphic.
Vera Dias, V Ribeiro
doaj   +1 more source

Context-dependent compensation among phosphatidylserine-recognition receptors [PDF]

, 2017
Phagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance.
Han, Claudia Z, Lee, Chang Sup, Lysiak, Jeffrey J, Onengut-Gumuscu, Suna, Palczewski, Krzysztof, Penberthy, Kristen K, Perry, Justin SA, Ravichandran, Kodi, Raymond, Michael H, Rival, Claudia, Shankman, Laura S, Zhang, Jianye   +11 more
core   +3 more sources

Identification of Novel Regulatory Cholesterol Metabolite, 5-Cholesten, 3β,25-Diol, Disulfate [PDF]

, 2014
Oxysterol sulfation plays an important role in regulation of lipid metabolism and inflammatory responses. In the present study, we report the discovery of a novel regulatory sulfated oxysterol in nuclei of primary rat hepatocytes after overexpression of ...
Kakiyama, Genta, Kim, Jin Koung, Min, Hae-Ki, Ning, Yanxia, Pandak, William M., Ren, Shunlin, Rodriguez-Agudo, Daniel   +6 more
core   +3 more sources

Oat β‐Glucan and Galactooligosaccharides Influence Gallstone Formation by Modulating the Gut Microbiota, Particularly Desulfovibrionales

iMetaMed, Volume 2, Issue 1, March 2026.
Oat β‐glucan and galactooligosaccharides influence the formation of gallstones by modulating the gut microbiota, particularly the abundance of Desulfovibrionales. The primary mechanism involves metabolic byproducts associated with Desulfovibrionales inhibiting hepatic bile acid synthesis via both the hepatic FXR–SHP and intestinal FXR–FGF15 signaling ...
Liang Tian, Yanyan Lin, Ping Yue, Long Gao, Leiqing Wang, Chongfei Huang, Jinyu Zhao, Ningzu Jiang, Jiahui xi, Haidong Ma, Zhen Liu, Ruyang Zhong, Wenkang Fu, Ningning Mi, Mingzhen Bai, Bodong Zhang, Lunzhi Dai, Jiang Li, Hu Chen, Jinqiu Yuan, Wenbo Meng   +20 more
wiley   +1 more source

N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

Frontiers in Pharmacology, 2018
N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis.
Nicole El-Darzi, Artem Astafev, Natalia Mast, Aicha Saadane, Morrie Lam, Irina A. Pikuleva   +5 more
doaj   +1 more source

Multi‐Target Mechanisms of Whey Protein Against NAFLD: Integrating Bile Acid Metabolism, Gut Microbiota and Hepatic Inflammation [PDF]

Food Sci Nutr
Whey protein (WP) alleviates high‐fat diet (HFD)‐induced nonalcoholic fatty liver disease (NAFLD) through a tripartite mechanism targeting the gut‐liver axis. (1) Gut Microbiota Modulation: WP restores intestinal flora homeostasis by enriching beneficial taxa (e.g., Lactobacillus) and increasing the production of short‐chain fatty acids (SCFAs).
Xu D, Qiu B, Dong X, Tan J, Xie Y, Wan Y, Chu C, Miao C, Ali A, Chen M, He J, Wu L, Xie J.   +12 more
europepmc   +2 more sources

Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina [PDF]

, 2011
Background Alzheimer's disease (AD) and age-related macular degeneration (AMD) share several pathological hallmarks including β-amyloid (Aβ) accumulation, oxidative stress, and apoptotic cell death.
Bhanu Dasari, Jaya RP Prasanthi, Gurdeep Marwarha, Brij B Singh, Othman Ghribi   +4 more
core   +2 more sources