Modules identification in gene positive networks of hepatocellular carcinoma using pearson agglomerative method and Pearson cohesion coupling modularity [PDF]
, 2012 In this study, a gene positive network is proposed based on a weighted undirected graph, where the weight represents the positive correlation of the genes.
Gao, Zhiwei, Hu, Jinyu
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Abstract 199: Host CYP27A1 expression is essential for ovarian cancer progression
Cancer Research, 2018 Abstract Ovarian cancer continues to have a high mortality and recurrence rate. Hence, there is an urgent need to develop new therapeutic or lifestyle strategies. In this regard, epidemiological studies have implicated elevated cholesterol as a negative prognostic factor.
Sisi He +4 more
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A Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the Gut-Liver-Kidney Axis. [PDF]
, 2019 Genes central to drug absorption, distribution, metabolism and elimination (ADME) also regulate numerous endogenous molecules. The Remote Sensing and Signaling Hypothesis argues that an ADME gene-centered network-including SLC and ABC "drug" transporters,
Bush, Kevin T +2 more
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Current trends in oxysterol research [PDF]
, 2016 In this short review we provide a synopsis of recent developments in oxysterol research highlighting topics of current interest to the community. These include the involvement of oxysterols in neuronal development and survival, their participation in the
Alvelius +54 more
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Selective inhibition of CYP27A1 and of chenodeoxycholic acid synthesis in cholestatic hamster liver
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2002 The aim of this study was to explore the regulation of serum cholic acid (CA)/chenodeoxycholic acid (CDCA) ratio in cholestatic hamster induced by ligation of the common bile duct for 48 h. The serum concentration of total bile acids and CA/CDCA ratio were significantly elevated, and the serum proportion of unconjugated bile acids to total bile acids ...
Matsuzaki, Yasushi +9 more
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Asthma and genes encoding components of the vitamin D pathway [PDF]
, 2009 Background :\ud Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy.\ud \ud Methods :\ud Eleven ...
Alan L James +15 more
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ApoA-I mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer [PDF]
, 2017 Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast ...
Blanco-Vaca, Francisco +7 more
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Orphanet Journal of Rare Diseases, 2010 Article abstract Mutations of the gene encoding the mitochondrial enzyme sterol 27-hydroxylase (CYP27A1 gene) cause defects in the cholesterol pathway to bile acids that lead to the storage of cholestanol and cholesterol in tendons, lenses and the ...
Garuti Rita +4 more
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Late-onset Cerebrotendinous Xanthomatosis with a Novel Mutation in the CYP27A1 Gene.
Internal medicine (Tokyo, Japan), 2018 Cerebrotendinous xanthomatosis (CTX) is a rare, autosomal recessive, inborn disruption in bile acid synthesis characterized by severe systemic xanthomas, cataracts and neurological injuries occurring before adolescence without elevation of the serum cholesterol or triglyceride levels.
Sasamura, Akari +15 more
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Retinal pigment epithelium cholesterol efflux mediated by the 18kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration [PDF]
, 2017 Biswas, Lincoln +4 more
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