Results 91 to 100 of about 40,704 (273)

In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach [PDF]

, 2019
The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled.
Croubels, Siska, De Baere, Siegrid, Devreese, Mathias, Millecam, Joske   +3 more
core   +1 more source

Pharmacogenomics in the UK National Health Service: Progress towards implementation

British Journal of Clinical Pharmacology, EarlyView.
Over the past decade there has been considerable and growing enthusiasm about the promise of using genomics to inform healthcare. In particular, using genetic data to inform prescribing practice has emerged as a compelling policy priority for health systems around the world, not least in the NHS.
John H. McDermott, Maria Tsakiroglou, William G. Newman, Munir Pirmohamed   +3 more
wiley   +1 more source

Distribution ofCYP2C19*2andCYP2C19*3polymorphisms in Venezuelan populations with different admixture

Annals of Human Biology, 2012
The conquest and colonization of Venezuela generated very heterogeneous populations as a product of admixture; for this reason, the distribution of polymorphisms of the CYP2C19 gene was studied in various Venezuelan populations.Two hundred and eighty-one individuals, from three Venezuelan populations with different admixtures, were genotyped for ...
Mary Helen Izaguirre, Dinorah Castro de Guerra, Sara Flores   +2 more
openaire   +3 more sources

Influence of CYP2C19 Metabolizer Status on Escitalopram/Citalopram Tolerability and Response in Youth With Anxiety and Depressive Disorders

Frontiers in Pharmacology, 2019
In pediatric patients, the selective serotonin reuptake inhibitors (SSRIs) escitalopram and citalopram (es/citalopram) are commonly prescribed for anxiety and depressive disorders. However, pharmacogenetic studies examining CYP2C19 metabolizer status and
Stacey L Aldrich, Ethan A Poweleit, C. Prows, Lisa J. Martin, J. Strawn, L. Ramsey   +5 more
semanticscholar   +1 more source

Transcriptome analyses reveal reduced hepatic lipid synthesis and accumulation in more feed efficient beef cattle [PDF]

, 2018
peer-reviewedThe genetic mechanisms controlling residual feed intake (RFI) in beef cattle are still largely unknown. Here we performed whole transcriptome analyses to identify differentially expressed (DE) genes and their functional roles in liver ...
Fitzsimmons, Carolyn, Keogh, Kate, Li, Changxi, Mukiibi, Robert, Stothard, Paul, Vinsky, Michael, Waters, Sinead M.   +6 more
core   +2 more sources

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

The frequency of CYP2C19 genetic polymorphisms in Russian patients with peptic ulcers treated with proton pump inhibitors

Pharmacogenomics and Personalized Medicine, 2015
DA Sychev,1,2 NP Denisenko,1,2 ZM Sizova,2 AV Grachev,3 KA Velikolug4 1Russian Medical Academy of Post-Graduate Education, 2I.M. Sechenov First Moscow State Medical University, 3SM-Clinic, 4Out-patient department Number 51 branch 3, Moscow, Russia ...
Sychev DA, Denisenko NP, Sizova ZM, Grachev AV, Velikolug KA   +4 more
doaj  

Impact of CYP2C19, CYP3A4, ABCB1, and FMO3 genotypes on plasma voriconazole in Thai patients with invasive fungal infections

Pharmacology Research & Perspectives, 2020
Voriconazole is the first‐line antifungal choice in the treatment of invasive fungal infections (IFIs). Single nucleotide polymorphisms (SNPs) in drug‐metabolizing and transporter genes may affect voriconazole pharmacokinetics.
Sumonrat Chuwongwattana, T. Jantararoungtong, S. Prommas, Sadeep Medhasi, A. Puangpetch, C. Sukasem   +5 more
semanticscholar   +1 more source

Stereoselective pharmacokinetics of stable isotope (+/-)-[13C]-pantoprazole: Implications for a rapid screening phenotype test of CYP2C19 activity [PDF]

, 2011
AIMS: We have previously shown that the (±)-[(13) C]-pantoprazole breath test is a promising noninvasive probe of CYP2C19 activity. As part of that trial, plasma, breath test indices and CYP2C19 (*2, *3, and *17) genotype were collected.
Desta, Zeruesenay, Flockhart, David A., Modak, Anil, Nguyen, Phuong D., Thacker, David L.   +4 more
core   +1 more source

Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives

Chemistry &Biodiversity, EarlyView.
ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos, Marie Demonceaux, Lucia Emanueli Schimith, Marine Goux, Claude Solleux, Ana Luiza Muccillo‐Baisch, Bruno Dutra Arbo, Corinne Andre‐Miral, Mariana Appel Hort   +8 more
wiley   +1 more source