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Биомедицина, 2013 Individual variation in the response to drug therapy has been mainly attributed to the genetic polymorphism of cytochrome P 450 isoenzymes. We examined 40 patients with CHD, who received clopidogrel and 146 healthy volunteers. CYP2C19*2, CYP2C19*3, CYP2C19*17 carriage was determined by a polymerase chain reaction.
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From genes to drugs: CYP2C19 and pharmacogenetics in clinical practice
Frontiers in PharmacologyThe CYP2C19 gene is frequently included in different pharmacogenomic panels tested in clinical practice, due to its involvement in the metabolism of a myriad of frequently prescribed medications.
Qamar Shubbar +8 more
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BMC Cardiovascular DisordersBackground Genetic variations in the CYP2C19 gene, which encodes the major enzyme responsible for activating clopidogrel, may influence response to Clopidogrel antiplatelet therapy.
Nour Haj Saleh, Lama A. Youssef
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Pharmacogenomics and Personalized Medicine, 2019 Margarita N Dorofeeva,1 Evgenia V Shikh,2 Zhanna M Sizova,1 Alisa V Tarasenko,3 Natalia P Denisenko,4,5 Valeriy V Smirnov,6,7 Kristina A Ryzhikova,4 Zhannet A Sozaeva,4 Elena A Grishina,4 Dmitriy A Sychev5 1Department of Social Expertise, Urgent and ...
Dorofeeva MN +9 more
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