Open MedicineN6-methyladenosine (m6A) is the most frequently occurring interior modification in eukaryotic messenger RNA (mRNA), and abnormal mRNA modifications can affect many biological processes.
Tan Quandan +14 more
doaj +1 more source
Molecular Oncology, Volume 19, Issue 8, Page 2412-2430, August 2025.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Two Single-Tube Tetra-Primer Assays to Detect the CYP2C19*2 and *3 Alleles of S-Mephenytoin Hydroxylase [PDF]
, 2001 Martin Hersberger +3 more
openalex +1 more source
Drug–drug interaction profile of ritlecitinib as perpetrator and victim through cytochrome P450
British Journal of Clinical Pharmacology, Volume 91, Issue 8, Page 2316-2326, August 2025.Aims To assess the effect of a potent cytochrome P450 (CYP) 3A inhibitor and CYP inducer on the pharmacokinetics of ritlecitinib, a JAK3/TEC family kinase inhibitor, and assess the effect of ritlecitinib on the pharmacokinetics of CYP substrates (midazolam, efavirenz, tolbutamide, caffeine and oral contraceptives [ethinyl oestradiol and levonorgestrel])
Vivek S. Purohit +6 more
wiley +1 more source
Inhibition of Cytochrome P450 (CYP450) Isoforms by Isoniazid: Potent Inhibition of CYP2C19 and CYP3A [PDF]
, 2001 Zeruesenay Desta +2 more
openalex +1 more source
Pharmacogenomics in the UK National Health Service: Progress towards implementation
British Journal of Clinical Pharmacology, Volume 91, Issue 8, Page 2241-2250, August 2025.Over the past decade there has been considerable and growing enthusiasm about the promise of using genomics to inform healthcare. In particular, using genetic data to inform prescribing practice has emerged as a compelling policy priority for health systems around the world, not least in the NHS.
John H. McDermott +3 more
wiley +1 more source
Influence of gender and oral contraceptives on CYP2D6 and CYP2C19 activity in healthy volunteers [PDF]
, 2001 Staffan Hägg +2 more
openalex +1 more source
Pharmacokinetic Prediction and Cytotoxicity of New Quercetin Derivatives
Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.ABSTRACT Quercetin (QUE) possesses various pharmacological properties; however, its low bioavailability and solubility hinder its beneficial effects. Enzymatic glycosylation has been explored to improve these aspects. In the present study, we used a sucrose phosphorylase variant to catalyze the regioselective transglucosylation of QUE, predicted the ...
Michele Goulart dos Santos +8 more
wiley +1 more source
Trombocita aggregáció gátló kezelés hatékonyságának genetikai és metodikai aspektusai koronária intervención átesett betegek körében [PDF]
, 2011 Coronary artery disease (CAD) is known to be a very heterogeneous disease of multifactorial origin affecting millions world-wide and being the top leading cause of death among the middle-aged population.
Rideg Orsolya
core +1 more source
Effect of the CYP2C19 oxidation polymorphism on fluoxetine metabolism in Chinese healthy subjects [PDF]
, 2001 Zhaoqian Liu +6 more
openalex +1 more source