Results 141 to 150 of about 45,621 (284)

Pengaruh Variasi Genetika Cyp2c19 Terhadap Efek Sedasi Midazolam Intravena

JAI (Jurnal Anestesiologi Indonesia), 2009
Latar Belakang: Sitokrom P450 berperan penting dalam metabolisme obat, zat kimia dan karsinogen. CYP2C19 sering menjadi perhatian utama karena tingginya perbedaan ditiap individu maupun tiap populasi.
Sukmiasi Sismadi, uripno Budiono
doaj   +1 more source

Chemical Composition and Antibacterial Potential of Lavandula latifolia and Lavandula angustifolia Essential Oils Against Bacillus cereus Isolated From Pipelines of Dairy Industry

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
1,8‐Cineole, limonene, and camphor were abundant in Algerian Lavandula latifolia essential oil, whereas linalol and linalyl acetate were in Lavandula angustifolia. MIC and MBC results revealed L. latifolia oil was the most effective against Bacillus cereus. Hexyl butyrate and lavandulyl acetate, among others, bound efficiently to the active site of the
Mounir Saifi, Nassima Didouh, Nadia Aissaoui, Zahia Khiri, Khadidja Medjahdi, Rachid Achek, Ismail Daoud, Ricardo Araujo   +7 more
wiley   +1 more source

Gastroenteroloji Alanında Farmakogenetik Bilginin Kullanılması

Ankara Medical Journal, 2016
İlaçlara karşı elde edilen yanıtların bireyler veya etnik gruplar arasındaki farklılıklarının nedenini açıklayan araştırma alanı farmakogenetik bilimidir.
Mustafa Tuğrul Göktaş, Halil Kara
doaj   +1 more source

Cytotoxic and Antileishmanial Potential of Pilocarpus microphyllus Essential Oil: In Vitro and In Silico Study

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Jaborandi (Pilocarpus microphyllus) essential oil is obtained by removal and characterization using GC‐MS, revealing γ‐cadinene and trans‐caryophyllene as major constituents. The oil exhibits biological activity, with antifungal action against Candida spp.
Juniel Cruz Silva, Maria Gabriela Araújo Mendes, Paulo Sérgio de Araujo Sousa, Alyne Rodrigues de Araújo Nobre, Michel Muálem de Moraes Alves, Fernando Aécio de Amorim Carvalho, Tatiane Caroline Daboit, José de Sousa Lima Neto, Ygor Victor Ferreira Pinheiro, Ytallo da Costa Sousa, Edymilaís da Silva Sousa, José Delano Barreto Marinho Filho, Ana Jérsia Araújo, Francisco Artur Silva Filho, Sidney Gonçalo de Lima, Leiz Maria Costa Véras   +15 more
wiley   +1 more source

Polymorphisms of CYP2C8, CYP2C9 and CYP2C19 and risk of coronary heart disease in Russian population [PDF]

, 2017
Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding
Bykanova, M., Kharchenko, A., Polonikov, A., Ponomarenko, I., Sirotina, S.   +4 more
core   +2 more sources

Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT This study isolated a compound with anti‐inflammatory properties from Musa × paradisiaca fruit peels. The methanol extract was partitioned, and the hexane fraction with the best bioactivity was subjected to column chromatography before characterization via Fourier transform infrared (FTIR), UV–visible (UV–VIS) and NMR analysis.
Ibeabuchi J. Ali, Kolawole A. Olofinsan, Goodnews O. Ikeh, Ndidiamaka H. Okorie, Cyril C. Adonu, Romanus C. Omeh, Blessing C. Idoko, Pamela E. Nnamani   +7 more
wiley   +1 more source

Targeting the TRIM28–EZH2 Protein–Protein Interface With Cysteine‐Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Graphical overview of the computational strategy employed to disrupt the oncogenic TRIM28EZH2 proteinprotein interaction. The workflow illustrates proteinprotein docking to define the interaction interface, cysteine‐focused covalent virtual screening targeting EZH2 Cys144, covalent docking, molecular dynamics simulations, and MM‐GBSA binding free ...
Ibrahim Oluwatobi Kehinde, Vuyisa Mzozoyana, Sizwe J. Zamisa, Mbuso Faya, Mahmoud E. S. Soliman   +4 more
wiley   +1 more source

Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation [PDF]

, 2012
BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon.
BORRO, Marina, D. A. Lamis, GENTILE, Giovanna, GIRARDI, Paolo, LALA, NOEMI, M. Innamorati, MARTELLETTI, Paolo, NEGRO, ANDREA, POMPILI, Maurizio, SERAFINI, Gianluca, SIMMACO, Maurizio   +10 more
core  

CLOPIDOGREL PHARMACOGENETICS

Рациональная фармакотерапия в кардиологии, 2016
Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj   +1 more source

Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene-drug interaction between CYP2C19 and CYP2D6 and SSRIs

European Journal of Human Genetics, 2021
J. Brouwer, M. Nijenhuis, Bianca Soree, H. Guchelaar, J. Swen, R. V. van Schaik, J. Weide, G. Rongen, Anne M Buunk, Nienke J. de Boer-Veger, E. Houwink, R. van Westrhenen, B. Wilffert, V. Deneer, H. Mulder   +14 more
semanticscholar   +1 more source