Results 161 to 170 of about 40,704 (273)

Clinical Evaluation of Risankizumab-rzaa in the Treatment of Plaque Psoriasis. [PDF]

, 2020
Risankizumab-rzaa (Skyrizi®; AbbVie) is a humanized IgG monoclonal antibody directed against interleukin-23p19 (IL-23p19) indicated for the treatment of moderate-to-severe psoriasis in adults who are candidates for systemic therapy or phototherapy.
Liao, Wilson, Myers, Bridget, Reddy, Vidhatha, Yang, Eric J   +3 more
core   +1 more source

Large‐Scale Production of Expandable Hepatoblast Organoids and Polarised Hepatocyte Organoids From hESCs Under 3D Static and Dynamic Suspension Conditions

Cell Proliferation, EarlyView.
Under 3D suspension culture condition, the expandable hepatoblast organoids and mature polarised hepatocyte organoids were established by low concentration of Matrigel from human embryonic stem cells, which recapitulated the gene expression signatures and functions of primary human hepatoblast and hepatocytes.
Haibin Wu, Jue Wang, Shoupei Liu, Yiyu Wang, Xianglian Tang, Jinghe Xie, Ning Wang, Huanhuan Shan, Sen Chen, Xueyan Zhang, Weiping Zeng, Chuxin Chen, Yinjie Fu, Liangxue Lai, Yuyou Duan   +14 more
wiley   +1 more source

Safety and effectiveness of stiripentol in patients with Dravet syndrome: A prospective, 3‐year, postmarketing surveillance study

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16285 Abstract Aim To conduct a postmarketing surveillance study of patients with Dravet syndrome in Japan to investigate the safety and effectiveness of long‐term, real‐world, clinical use of stiripentol (STP).
Yuki Kitamura, Hiroaki Ohyabu, Tatsuo Miura, Naomi Takei‐Masuda, Daisuke Matsui, Yushi Inoue, Yoko Ohtsuka   +6 more
wiley   +1 more source

CYP2C9, CYPC19 and CYP2D6 gene profiles and gene susceptibility to drug response and toxicity in Turkish population

Saudi Pharmaceutical Journal, 2017
Pharmacogenetics is a vast field covering drug discovery research, the genetic basis of pharmacokinetics and dynamics, genetic testing and clinical management in diseases.
Merve Arici, Gül Özhan
doaj   +1 more source

CYP2C19-Guided Escitalopram and Sertraline Dosing in Pediatric Patients: A Pharmacokinetic Modeling Study.

Journal of child and adolescent psychopharmacology, 2019
Objective: Cytochrome P4502C19 (CYP2C19) is a highly polymorphic gene that encodes an enzyme that metabolizes escitalopram and sertraline, two selective serotonin reuptake inhibitors (SSRIs) that are FDA approved for pediatric use and commonly used to ...
J. Strawn, Ethan A Poweleit, L. Ramsey
semanticscholar   +1 more source

Polymorphic drug metabolising enzymes:Assessment of activities by phenotyping and genotyping in clinical pharmacology [PDF]

, 2001
Drug effects (pharmacodynamics) are determined by drug concentration at target site and the affinity of the drug for a target. Pharmacogenetics describes inherited differences in drug metabolising enzyme activities and differences in drug transporters ...
Tamminga, Willem Jan
core   +2 more sources

Status epilepticus in older adults: A critical review

Epilepsia, EarlyView.
Abstract Older adults (≥60 years of age) have the highest incidence of status epilepticus (SE) among adults and experience the highest morbidity and mortality. SE incidence increases with age in adulthood. A recent study from Austria estimated an incidence of 89.6/100 000 and 67.6/100 000 person‐years adjusted for age and sex in women and men aged >60 ...
Matthew R. Woodward, Michael J. Armahizer, Tina I. Wang, Neeraj Badjatia, Emily L. Johnson, Emily J. Gilmore   +5 more
wiley   +1 more source

Effect of Potassium‐Competitive Acid Blockers on Upper Gastrointestinal Bleeding in Patients on Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: A Nationwide Cohort Study

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Proton pump inhibitors (PPIs) are the drug of choice to prevent upper gastrointestinal (UGI) bleeding in patients receiving dual antiplatelet therapy (DAPT); however, unmet needs remain. Potassium‐competitive acid blockers (P‐CABs) are novel acid‐suppressive drugs that have emerged as potential alternatives. We evaluated the
Minyoul Baik, Jimin Jeon, Joonsang Yoo, Jinkwon Kim   +3 more
wiley   +1 more source

Vonoprazan or Proton Pump Inhibitor for Gastric Endoscopic Submucosal Dissection in Patients Taking Antithrombotic Agents

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aim Delayed bleeding is a major concern after gastric endoscopic submucosal dissection (ESD), especially in patients taking antithrombotic agents. The aim of this study was to evaluate the superiority of vonoprazan (VPZ) over proton pump inhibitor (PPI) in preventing delayed bleeding after gastric ESD in patients taking ...
Hiroyuki Shibata, Toshihisa Fujiyoshi, Noboru Kawata, Tomohiko Obayashi, Masaya Esaki, Masakazu Kikuchi, Naohiro Yoshida, Tsuguo Kamioka, Yoji Sasaki, Makoto Kobayashi, Muneyori Okita, Shigeyuki Matsui, Kazuhiro Furukawa, Masanao Nakamura, Naomi Kakushima, Mitsuhiro Fujishiro, Hiroki Kawashima   +16 more
wiley   +1 more source

Omega-3 Polyunsaturated Fatty Acids in Treatment of Patients with Coronary Heart Disease and Type 2 Diabetes Mellitus [PDF]

, 2012
Increased platelet aggregation is one of the major risk factors for cardiovascular events. However, recent studies have demonstrated the inhibition of platelet aggregation by omega-3 PUFAs.
Aisulu T. Mussagalieva, MD, PhD, Gulnara M. Imantaeva, MD, PhD   +1 more
core