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Effect of CYP2C8 genotype on rosiglitazone pharmacokinetics
Clinical Pharmacology & Therapeutics, 2005Background/Aims The purpose of this study was to investigate the effect of the CYP2C8 genetic polymorphisms CYP2C8*2, CYP2C8*3, and CYP2C8*4 on the pharmacokinetics of rosiglitazone, a PPARγ agonist and CYP2C8 substrate. Methods This single dose pharmacokinetics study involved thirty-eight healthy subjects with the following CYP2C8 ...
M HRUSKA +4 more
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CYP2C8 polymorphism frequencies among malaria patients in Zanzibar
European Journal of Clinical Pharmacology, 2005The determination of the prevalence of the CYP2C8 main alleles in a typical set of malaria patients in Zanzibar, as these patients represent a typical population exposed to amodiaquine, an antimalarial mainly metabolized by CYP2C8. Also, to determine for the first time the frequencies of CYP2C8 alleles in native African populations.Polymerase chain ...
I, Cavaco +7 more
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Drug Metabolism and Disposition, 2011
The objectives of this study were to identify the genetic variants of CYP2C8, analyze CYP2C8 single nucleotide polymorphisms (SNPs), and characterize their functional consequences in the CYP2C8 substrate drug rosiglitazone in humans. The direct full sequencing of CYP2C8 genomic DNA was performed in a Korean population (n = 50).
Chang-Woo, Yeo +7 more
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The objectives of this study were to identify the genetic variants of CYP2C8, analyze CYP2C8 single nucleotide polymorphisms (SNPs), and characterize their functional consequences in the CYP2C8 substrate drug rosiglitazone in humans. The direct full sequencing of CYP2C8 genomic DNA was performed in a Korean population (n = 50).
Chang-Woo, Yeo +7 more
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Frequency of CYP2C8*2 and CYP2C8*3 alleles in Ugandan children exposed to Malaria
2014aaa
G. M. Paganotti +6 more
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The impact of a CYP2C8-CYP3A4 protein–protein interaction on time dependent inhibition of CYP2C8
Drug Metabolism and Pharmacokinetics, 2018Andrea Whitcher-Johnstone, Tom S. Chan
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2016
Purpose: To determine the frequency of the genotype’s of CYP2C8 K399R rs10509681 and CYP2C8 R139K rs11572080 in patients with age-related macular degeneration. Methods: The study enrolled n=305 patients with early age-related macular degeneration and a random sample of the population n=300 (reference group).
Sungailienė, Ramunė +4 more
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Purpose: To determine the frequency of the genotype’s of CYP2C8 K399R rs10509681 and CYP2C8 R139K rs11572080 in patients with age-related macular degeneration. Methods: The study enrolled n=305 patients with early age-related macular degeneration and a random sample of the population n=300 (reference group).
Sungailienė, Ramunė +4 more
openaire +1 more source