Results 221 to 230 of about 35,596 (239)

ROLE OF CYP2C9 AND ITS VARIANTS (CYP2C9*3 AND CYP2C9*13) IN THE METABOLISM OF LORNOXICAM IN HUMANS

Drug Metabolism and Disposition, 2005
CYP2C9 is an important member of the cytochrome P450 enzyme superfamily with some 12 CYP2C9 alleles (*1-*12) being previously reported. Recently, we identified a new CYP2C9 allele with a Leu90Pro mutation in a Chinese poor metabolizer of lornoxicam [Si D, Guo Y, Zhang Y, Yang L, Zhou H, and Zhong D (2004) Pharmacogenetics 14:465-469].
Yingjie, Guo, Yifan, Zhang, Ying, Wang, Xiaoyan, Chen, Dayong, Si, Dafang, Zhong, J Paul, Fawcett, Hui, Zhou   +7 more
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CYP2C9*3/*3 : rijetki genotip CYP2C9

2003
Enzim CYP2C9 je odgovoran za metabolizam S-varfarina. Uz divlji tip alela CYP2C9*1, najčešće aleli u bjelačkoj populaciji su CYP2C9*2 i CYP2C9*3. Cilj rada bio je ispitivanje povezanosti polimorfizma CYP2C9 s varijabilnošću doze varfarina u bolesnika na antikoagulantnoj terapiji.
Samaržija, Marina, Topić, Elizabeta, Štefanović, Mario, Vidović, Sanja, Miskulin, Ivica   +4 more
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Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59

Drug Metabolism and Disposition, 2015
CYP2C9, one of the most important drug-metabolizing enzymes, is responsible for metabolizing approximately 15% of clinically important drugs, including warfarin, diclofenac, and losartan. Similar to other CYP members, human CYP2C9 exhibits marked genetic polymorphisms among individuals of different ethnicities. In this study, a novel missense mutation (
Da-Peng, Dai, Shuang-Hu, Wang, Chuan-Bao, Li, Pei-Wu, Geng, Jie, Cai, Hao, Wang, Guo-Xin, Hu, Jian-Ping, Cai   +7 more
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Polymorphic Variants (CYP2C9*3 and CYP2C9*5) and the F114L Active Site Mutation of CYP2C9: Effect on Atypical Kinetic Metabolism Profiles

Drug Metabolism and Disposition, 2002
CYP2C9 wild-type protein has been shown to exhibit atypical kinetic profiles of metabolism that may affect in vitro-in vivo predictions made during the drug development process. Previous work suggests a substrate-dependent effect of polymorphic variants of CYP2C9 on the rate of metabolism; however, it is hypothesized that these active site amino acid ...
Timothy S, Tracy, J Matthew, Hutzler, Robert L, Haining, Allan E, Rettie, Matthew A, Hummel, Leslie J, Dickmann   +5 more
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Allele frequency distribution of CYP2C9*2 and CYP2C9*3 polymorphisms in six Mexican populations

Gene, 2013
Allele frequency differences of functional CYP2C9 polymorphisms are responsible for some of the variation in drug response observed in human populations. The most relevant CYP2C9 functional variants are CYP2C9*2 (rs1799853) and CYP2C9 3 (rs1057910). These polymorphisms show variation in allele frequencies among different population groups.
Osvaldo D, Castelán-Martínez, Carlos, Hoyo-Vadillo, Emmanuel, Sandoval-García, Lucila, Sandoval-Ramírez, Miriam, González-Ibarra, Gloria, Solano-Solano, Rita A, Gómez-Díaz, Esteban J, Parra, Miguel, Cruz, Adán, Valladares-Salgado   +9 more
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Identification and Functional Characterization of a New CYP2C9 Variant (CYP2C9*5) Expressed among African Americans

Molecular Pharmacology, 2001
CYP2C9 is a polymorphic gene for which there are four known allelic variants; CYP2C9*1, CYP2C9*2, CYP2C9*3, and CYP2C9*4. In the present study, DNA from 140 European Americans and 120 African Americans was examined by single-strand conformational polymorphism and restriction fragment length polymorphism analyses, resulting in the identification of a ...
L J, Dickmann, A E, Rettie, M B, Kneller, R B, Kim, A J, Wood, C M, Stein, G R, Wilkinson, U I, Schwarz   +7 more
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Significance of CYP2C9 genetic polymorphism in inhibitory effect of Δ9-tetrahydrocannabinol on CYP2C9 activity

Forensic Toxicology, 2012
We recently reported that Δ9-tetrahydrocannabinol (Δ9-THC), the primary psychoactive constituent in marijuana, potently inhibits the catalytic activity of cytochrome P450 (CYP) 2C9.1, a wild-type variant. However, effects of CYP2C9 genetic polymorphisms on the inhibitory potency of Δ9-THC have not been investigated.
Satoshi Yamaori, Mika Kushihara, Kyoko Koeda, Ikuo Yamamoto, Kazuhito Watanabe   +4 more
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???????????? ???????????????????????????? ?????????????????? ???????????????????????? ???????? CYP2C9 ?? ?????????????????? ??????????????????

2014
???????????????? ???????????? ???????????????????????????? ???????????????????? ?????????????????????? ?????????????????? 430?? > ?? ?? 1075?? > ?? ???????? ?????????????????? ??450 CYP2C9 ?? ?????????????? ?????????????????????? ?????????????????? ?? ?? ?????????????? ???????????????? ?????? ?????????????????? ??????????????????. ????????????????, ????
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CYP2C9 polymorphisms in human tumors.

Anticancer research, 2006
The oxazaphosphorines cyclophosphamide (CP) and ifosfamide (IF) are alkylating agents that require bioactivation via cytochrome (CYP) P450 isoenzymes including CYP2C9 enzymes. The present study investigated CYP2C9 in regard to its allelic variants in 23 tumor samples (10 breast tumors, 1 breast tumor cell line, 5 brain tumors, 7 glioma cell lines) with
Heike, Knüpfer, Dirk, Stanitz, Rainer, Preiss   +2 more
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Functional impact of CYP2C9*5, CYP2C9*6, CYP2C9*8, and CYP2C9*11 in vivo among black Africans*1

Clinical Pharmacology & Therapeutics, 2004
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