Results 71 to 80 of about 35,596 (239)

Distribution of polymorphisms in the CYP2C9 gene and CYP2C19/CYP2C9 haplotypes among Venezuelan populations

Annals of Human Biology, 2016
Polymorphisms with decreased enzyme activity of their gene products have been reported in region CYP2C with population variations in haplotype structure.To estimate the allelic and genotypic frequencies of variants CYP2C9*2 and CYP2C9*3 and of CYP2C9/CYP2C19 haplotypes in Venezuelan populations.Six hundred and thirty-four individuals from nine admixed ...
Sara Flores-Gutiérrez, Álvaro Rodríguez-Larralde, Merlyn Vívenes de Lugo, Dinorah Castro de Guerra   +3 more
openaire   +3 more sources

Efficacy and safety of switching to ezetimibe 10 mg/rosuvastatin 2.5 mg in Korean patients with type 2 diabetes mellitus and dyslipidaemia: A multicentre, prospective study (EROICA study)

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 906-913, February 2026.
Abstract Aims To evaluate the lipid‐lowering efficacy, safety, and adherence of switching from moderate‐ or low‐intensity statin monotherapy to ezetimibe 10 mg/rosuvastatin 2.5 mg in Korean patients with type 2 diabetes mellitus (T2DM) and dyslipidaemia.
Sangmo Hong, Won J. Kim, Sungrae Kim, Jung H. Park, Eun S. Kang, Min K. Moon, Jae T. Kim, Ji‐Oh Mok, Ki Y. Lee, Cheol‐Young Park, Chang B. Lee   +10 more
wiley   +1 more source

Pharmacogenetics Influence of CYP2C9*2 and *3 in Iraqi Type Two Diabetic Patients

, 2022
Ghada. S. Rasool*, Asmaa A. Hussien, Salwa J. Al-Awadi Al-Awadi   +2 more
openalex   +2 more sources

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source

Acanthospermum hispidum and Its Metabolite Stigmasterol Modulates Anti‐Inflammatory Antagonism of COX‐1 and TGF‐β

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
This study evaluates the anti‐inflammatory effect of Acanthospermum hispidum (AH) leaves and confirms its traditional use on diseases linked to inflammation. AH ethanol extract presents a dose‐dependent increase in anti‐inflammatory activity on the different times examined (T30 – T150). Also, stigmasterol present in AH shows potent antagonist influence
Onome Mary Adeboye, Abimbola Sowemimo, Muyiwa Samuel Fageyinbo, Oluwasegun Adedokun, Abdul Basit, Opeyemi Joshua Olatunji, Epole Ngolle Ntungwe   +6 more
wiley   +1 more source

Оцінка частоти призначення непрямих антикоагулянтів у хворих на гострий коронарний синдром з наявністю фібриляції передсердь неклапанного генезу та тромбоемболічних ускладнень в анамнезі та оптимізація цієї терапії [PDF]

, 2011
В исследовании изучили частоту назначения непрямых антикоагулянтов у больных с острым коронарным синдромом (ОКС) и наличием фибрилляции предсердий (ФП) неклапанного генеза и тромбоэмболических осложнений (ТЭУ) в анамнезе.
Васильєва, Л.І., Дзяк, Г.В., Калашникова, O.С., Сапожниченко, Л.В.   +3 more
core  

Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT This study isolated a compound with anti‐inflammatory properties from Musa × paradisiaca fruit peels. The methanol extract was partitioned, and the hexane fraction with the best bioactivity was subjected to column chromatography before characterization via Fourier transform infrared (FTIR), UV–visible (UV–VIS) and NMR analysis.
Ibeabuchi J. Ali, Kolawole A. Olofinsan, Goodnews O. Ikeh, Ndidiamaka H. Okorie, Cyril C. Adonu, Romanus C. Omeh, Blessing C. Idoko, Pamela E. Nnamani   +7 more
wiley   +1 more source

Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation [PDF]

, 2012
BACKGROUND: Risk factors for suicide are at least partially heritable and functional polymorphisms of targeted genes have been suggested to be implicated in the pathogenesis of this phenomenon.
BORRO, Marina, D. A. Lamis, GENTILE, Giovanna, GIRARDI, Paolo, LALA, NOEMI, M. Innamorati, MARTELLETTI, Paolo, NEGRO, ANDREA, POMPILI, Maurizio, SERAFINI, Gianluca, SIMMACO, Maurizio   +10 more
core  

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants [PDF]

, 2020
Lingxin Zhang, Vivekananda Sarangi, Irene Moon, Jia Yu, Duan Liu, Sandhya Devarajan, Joel M. Reid, Krishna R. Kalari, Liewei Wang, Richard M. Weinshilboum   +9 more
openalex   +1 more source

Targeting the TRIM28–EZH2 Protein–Protein Interface With Cysteine‐Reactive Covalent Inhibitors: A Computational Blueprint for Cancer Therapy

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Graphical overview of the computational strategy employed to disrupt the oncogenic TRIM28EZH2 proteinprotein interaction. The workflow illustrates proteinprotein docking to define the interaction interface, cysteine‐focused covalent virtual screening targeting EZH2 Cys144, covalent docking, molecular dynamics simulations, and MM‐GBSA binding free ...
Ibrahim Oluwatobi Kehinde, Vuyisa Mzozoyana, Sizwe J. Zamisa, Mbuso Faya, Mahmoud E. S. Soliman   +4 more
wiley   +1 more source