Results 81 to 90 of about 37,178 (276)

Phytochemical Composition and Potential Bioactivity With ADMET Analysis of Selected Species From Myrtaceae Family

Flavour and Fragrance Journal, EarlyView.
Investigation of four medicinal plants of the family Myrtaceae. ABSTRACT Compounds derived from natural sources continue to serve as chemical scaffolds for designing prophylactic/therapeutic options for human healthcare. This study aimed to evaluate the phytochemical composition, antioxidant potential, in vitro anti‐inflammatory, antibacterial and ...
Archana Joshi, Vaishnavi Rawat, Ravendra Kumar, Stefania Garzoli, Anil Kumar Pant, Marcin Stocki, Valery A. Isidorov, Om Prakash, Dharmendra Singh Rawat   +8 more
wiley   +1 more source

Development of an Efficient and Scalable Process for Preparing Timolol N‐Nitrosamine Impurities B, C, E, H, I, J, and Their ADMET Evaluation

Journal of Heterocyclic Chemistry, EarlyView.
N‐nitrosamine impurities (B, C, E, H, I, J) of timolol maleate are easily synthesized from diethyl malonate and 3,4‐dichloro‐1,2,5‐thiadiazole. Good yields and precise impurity profiling are made possible by the effective technique, which also ensures pharmaceutical safety and strengthens regulatory compliance.
Kottolla Sai Prasad, Chithaluri Sudhakar, Vijaya Krishna Ravi, Bijaya Kethan Sahoo   +3 more
wiley   +1 more source

Association of warfarin dose with genes involved in its action and metabolism [PDF]

, 2007
We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin.
Mia Wadelius, Leslie Y. Chen, Niclas Eriksson, Suzannah Bumpstead, Jilur Ghori, Claes Wadelius, David Bentley, Ralph McGinnis, Panos Deloukas, M Aiach, CL Aquilante, AA Arbini, KL Berkner, KL Berkner, L Bodin, D Cain, LY Chen, Y Chen, JM Cheverud, B Dahlbäck, AK Daly, RL D’Ambrosio, G D’Andrea, F Dudbridge, SB Gabriel, A Geick, C Geisen, RL Haining, W Huang, L Kaminsky, M Kohlmeier, H Kohnke, H Kohnke, SR Kristensen, C Landefeld, TB Larsen, SC Lee, JM Lehmann, H Li, T Li, R Loebstein, R Loebstein, C Morisseau, DR Nyholt, M Otagiri, G Palareti, JK Pritchard, AE Rettie, AE Rettie, MJ Rieder, S Rost, S Sanderson, J Saupe, EA Sconce, MG Scordo, E Shikata, CA Spek, N Sussman, H Takahashi, H Takahashi, H Takahashi, JF Heijden van der, M Vecsler, DL Veenstra, LE Visser, M Wadelius, M Wadelius, N Wajih, R Wallin, R Wallin, C Watala, SM Wu, HY Yuan, Z Zhang   +73 more
core   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for CYP2C9 and HLA-B Genotype and Phenytoin Dosing [PDF]

, 2014
Phenytoin is a widely used antiepileptic drug with a narrow therapeutic index and large inter-patient variability partly due to genetic variations in CYP2C9.
Callaghan, J. Thomas, Caudle, Kelly E., Klein, Teri E., Lee, Ming Ta Michael, Mintzer, Scott E., Rettie, Allan E., Smith, Lisa H., Whirl-Carrillo, Michelle   +7 more
core   +3 more sources

CLOPIDOGREL PHARMACOGENETICS

Рациональная фармакотерапия в кардиологии, 2016
Platelets play an important role in the pathogenesis of atherosclerosis. They are involved in atherosclerosis progression and thrombotic complications. That is why antiplatelet therapy is a necessary element of these complications prevention in patients ...
A. N. Meshkov
doaj   +1 more source

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial [PDF]

, 2016
Carboplatin/taxane combination is first-line therapy for ovarian cancer. However, patients can encounter treatment delays, impaired quality of life, even death because of chemotherapy-induced gastrointestinal (GI) toxicity.
Brown, R., Glass, S., He, Y.J., Hoskins, J.M., McLeod, H.L., Motsinger-Reif, A., Paul, J., Winham, S.J.   +7 more
core   +1 more source

The Troll Is Weakened but Not yet Defeated: An Update on Cytomegalovirus Management in Transplantation From the International CMV Symposium 2025

Transplant Infectious Disease, EarlyView.
This review synthesizes discussions from the 2025 International CMV Symposium on translating three recently updated international guidelines into clinical practice across solid organ and hematopoietic stem cell transplantation, highlighting advances in risk‐stratified prevention, emerging therapies, immune monitoring, and persistent implementation ...
Camille N. Kotton, Martina Sester, Julian Torre‐Cisneros, The International CMV Symposium Faculty   +3 more
wiley   +1 more source

Effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness during the stabilization phase of therapy

Saudi Pharmaceutical Journal, 2019
The main objective of this study is to assess the effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the stabilization phase of treatment.
Laith N. AL-Eitan, Ayah Y. Almasri, Rame H. Khasawneh   +2 more
doaj   +1 more source

Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1584-1596, June 2026.
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub, Martyn Howard, Brahim Achour, Jill Barber, Naved Alizai, Amin Rostami‐Hodjegan   +5 more
wiley   +1 more source