Results 81 to 90 of about 25,089 (208)
Saudi Pharmaceutical Journal, 2019 The main objective of this study is to assess the effects of CYP2C9 and VKORC1 polymorphisms on warfarin sensitivity and responsiveness in a Jordanian population during the stabilization phase of treatment.
Laith N. AL-Eitan +2 more
doaj +1 more source
Neuroprotection, EarlyView.Antiplatelet agents target the cyclooxygenase‐1 (COX‐1)/thromboxane A2 (TXA2) and adenosine diphosphate (ADP)‐P2Y12 (cytochrome P450 2C19 [CYP2C19]‐metabolized) platelet activation pathways, resulting in either drug resistance or over‐inhibition. The individualized therapeutic window balances ischemic risk (triggered by high on‐treatment platelet ...
Guoliang Zhu +7 more
wiley +1 more source
, 2007 Thesis (Ph.D.)--Chulalongkorn University, 2007There are high intraindividual, interindividual and interethnic variabilities in warfarin dosing. It is difficult to adjust or to predict the appropriate dose for individual patient.
Alisara Sangviroon
core
Rifampin induction and polymorphisms of CYP2C9
, 2007 GesamtdissertationTolbutamid ist als Probesubstrat zur Bestimmung der CYP2C9-Aktivität in vivo validiert. Die Wirkung von Rifampicin als CYP2C9 Enzym-Induktor ist in zahlreichen Studien belegt.
Kuon, Jonas
core +1 more source
Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events
Phytotherapy Research, EarlyView.An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia +1 more
wiley +1 more source
Polymorphisms of VKORC1 and CYP2C9 are associated with warfarin sensitivity in Chinese population
, 2017 LiQun Jia,1 Zanxin Wang,1,2 Jianlong Men,3 Heng Cai,4 Minxin Wei2 1Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, 2Department of Cardiac Surgery, Shenzhen Sun Yat-sen Cardiovascular Hospital, Shenzhen ...
Wei M, Jia LQ, Men J, Wang Z, Cai H
core
Phytotherapy Research, EarlyView.Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng +6 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit +5 more
wiley +1 more source
British Journal of Pharmacology, EarlyView.Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley +1 more source
Characterisation of
BMC Medical Genetics, 2009 Background Genetic influences on drug efficacy and tolerability are now widely known. Pharmacogenetics has thus become an expanding field with great potential for improving drug efficacy and reducing toxicity.
Dodoo Alexander NO +2 more
doaj +1 more source