Results 101 to 110 of about 37,178 (276)

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish

open access: yesChemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa   +17 more
wiley   +1 more source

Neuroprotective Effects of Carnosine Against Corticosterone‐Induced Depression and Memory Impairment

open access: yesFood Science &Nutrition, Volume 14, Issue 5, May 2026.
This main findings of the study and illustrates the key workflow. ABSTRACT Corticosterone (Crt) is reported to induce oxidative stress in experimental animals. Carnosine (Crn), a well‐known dipeptide antioxidant synthesized endogenously from β‐alanine and L‐histidine, neutralizes oxidative stress. The current study examines the influences of Crn on Crt‐
Muneezah Elahi   +6 more
wiley   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug‐Metabolizing Enzymes

open access: yesThe Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against hepatitis C virus. In vitro studies assessing the inhibition or induction potential of bemnifosbuvir on the CYP450 and UGT1A1 enzymes demonstrated that bemnifosbuvir is a weak inducer and a reversible and time‐dependent inhibitor of
Xiao‐Jian Zhou   +10 more
wiley   +1 more source

Acute Eruption in a Child With Acute Lymphoblastic Leukemia

open access: yes
Pediatric Dermatology, EarlyView.
L. Parra‐Navarro   +2 more
wiley   +1 more source

A model‐based analysis of the CYP2C9 genotype effects on fluconazole inhibition using flurbiprofen, ketoprofen and tolbutamide as probe drugs

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 10, Page 2482-2496, May 2026.
Background The activity of CYP2C9, an important drug metabolism enzyme, is subject to the impact of genetic polymorphism. The single nucleotide polymorphism *3 is significantly associated with the increased exposure of CYP2C9 substrates. In addition, metabolic enzyme inhibitors such as fluconazole may also increase the drug exposure of CYP2C9 ...
Shen Cheng   +5 more
wiley   +1 more source

The effect of CYP2C9*2, CYP2C9*3, and VKORC1-1639 G>A polymorphism in patients under warfarin therapy in city of Kermanshah

open access: yesResearch in Pharmaceutical Sciences, 2018
Polymorphism in the genes encoding CYP2C9 enzyme and VKORC1 reductase significantly influence warfarin dose requirement since patients with CYP2C9*2, CYP2C9*3 and VKORC1 mutant alleles require lower warfarin maintenance doses.
Zohreh Hosseinkhani   +7 more
doaj   +1 more source

Effects of a High‐Fat Meal on the Pharmacokinetics of Olverembatinib in Patients With Chronic Myeloid Leukemia

open access: yesClinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Olverembatinib is approved in China to treat patients with chronic‐ or accelerated‐phase chronic myeloid leukemia (CML‐CP or CML‐AP) with T315I mutations and CML‐CP that is resistant and/or intolerant to first‐ and second‐generation tyrosine kinase inhibitors.
Hengbang Wang   +8 more
wiley   +1 more source

The role of statin drugs in combating cardiovascular diseases –A review [PDF]

open access: yes, 2011
Statins clearly confer substantial benefit in people with established cardiovascular (CV) disease. Increased cholesterol levels have been associated with cardiovascular diseases (CVD), and statins are therefore used in the prevention of these diseases ...
Suresh Pichandi , Palanisamy Pasupathi, Y.Yagneswara Rao, Jawahar Farook, Athimoolam Ambika, Babu Shankar Ponnusha , Sathiyamoorthy Subramaniyam, Rajaram Virumandy, Boopathi subramaniyam Int J Cur Sci Res.
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