Results 101 to 110 of about 25,089 (208)
Genotyping of CYP2C9 for cardiovascular patients / Norshazareen Abd Manab [PDF]
, 2005 CYP2C9 lines the important drug-metabolizing cytochrome P450 isoforms in the human liver but linked with inter-individual variation in drug-response relationship due to single nucleotide polymorphism of the encoding gene.
Abd Manab, Norshazareen
core
Research in Molecular Medicine, 2016 Background: Warfarin is a common anticoagulant drug that has a narrow therapeutic index; higher dose causes excessive bleeding and lower dose leads to cerebrovascular clotting and stroke in patients.
Reyhaneh Kameli +7 more
doaj
Clinical and Translational Science, Volume 19, Issue 10, October 2026.Real‐world prescription data from 6230 adolescents and adults living with sickle cell disease (SCD) were combined with a drug–drug interaction (DDI) database to characterize the population‐level DDI risk. The findings support a DDI risk assessment for development of novel SCD therapies and during clinical management of SCD.ABSTRACTSickle cell disease ...
Rune Aabjerg Nørgaard +4 more
wiley +1 more source
Factors affecting CYP2C9-mediated metabolism [PDF]
, 2001 Cytochrome P450 enzymes can exhibit non-Michaelis-Menten, or atypical kinetics. In particular, dapsone activates CYP2C9-mediated flurbiprofen 4 \u27-hydroxylation. However, the mechanism of activation of CYP2C9 is poorly understood.
Hutzler, James Matthew
core
Genetic polymorphism of Cytochrome-P450-2C9 (CYP2C9) in Indian populations
, 2017 Cytochrome-P450-2C9 (CYP2C9) metabolizes wide range of drugs and highly express in human liver. Various mutations of CYP2C9 (R144C, I359L etc.), associated with drug-response, are highly diverse. We aimed to investigate the genetic diversity of CYP2C9 in
K Harish +7 more
core +1 more source
Genomic Medicine Sweden: Advancing precision medicine at the national level
Journal of Internal Medicine, Volume 300, Issue 4, Page 397-419, October 2026.Abstract High‐throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease‐causing genetic alterations and facilitating individualised treatment and care.
Anders Edsjö +58 more
wiley +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
Current Research in ToxicologyBrazil is the world leader in pesticide consumption, and its indiscriminate use puts farmers’ health at risk. The CYP2C9 gene encodes the CYP2C9 enzyme, which metabolizes several endogenous substrates and specific xenobiotics, especially pesticides.
Débora Dummer Meira +13 more
doaj +1 more source
Advanced Science, Volume 13, Issue 52, 18 September 2026.An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng +17 more
wiley +1 more source
Prevalence of CYP2C9 polymorphisms in the south of Europe.
, 2009 CYP2C9 is a major liver enzyme responsible of the metabolism of many clinically important drugs. The presence of CYP2C9 genetic polymorphisms has been associated with marked interindividual variability in its catalytic activity that could result in drug ...
PROVEZZA, Lisa +12 more
core +1 more source